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TRIM2 (tripartite motif containing 2)

Identity

Alias_namestripartite motif-containing 2
Alias_symbol (synonym)KIAA0517
RNF86
CMT2R
Other alias
HGNC (Hugo) TRIM2
LocusID (NCBI) 23321
Atlas_Id 75149
Location 4q31.3  [Link to chromosome band 4q31]
Location_base_pair Starts at 153153118 and ends at 153339322 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MALAT1 (11q13.1) / TRIM2 (4q31.3)TRIM2 (4q31.3) / ARFIP1 (4q31.3)TRIM2 (4q31.3) / CSNK1D (17q25.3)
TRIM2 (4q31.3) / KMT2A (11q23.3)TRIM2 (4q31.3) / MND1 (4q31.3)TRIM2 (4q31.3) / RASA3 (13q34)
TRIM2 (4q31.3) / SGSM3 (22q13.1)TRIM2 (4q31.3) / TRIM2 (4q31.3)TRIM2 (4q31.3) / WDR37 (10p15.3)
TRIM2 ARFIP1TRIM2 WDR37

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRIM2   15974
Cards
Entrez_Gene (NCBI)TRIM2  23321  tripartite motif containing 2
AliasesCMT2R; RNF86
GeneCards (Weizmann)TRIM2
Ensembl hg19 (Hinxton)ENSG00000109654 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109654 [Gene_View]  chr4:153153118-153339322 [Contig_View]  TRIM2 [Vega]
ICGC DataPortalENSG00000109654
TCGA cBioPortalTRIM2
AceView (NCBI)TRIM2
Genatlas (Paris)TRIM2
WikiGenes23321
SOURCE (Princeton)TRIM2
Genetics Home Reference (NIH)TRIM2
Genomic and cartography
GoldenPath hg38 (UCSC)TRIM2  -     chr4:153153118-153339322 +  4q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIM2  -     4q31.3   [Description]    (hg19-Feb_2009)
EnsemblTRIM2 - 4q31.3 [CytoView hg19]  TRIM2 - 4q31.3 [CytoView hg38]
Mapping of homologs : NCBITRIM2 [Mapview hg19]  TRIM2 [Mapview hg38]
OMIM614141   615490   
Gene and transcription
Genbank (Entrez)AB011089 AF220018 AI695362 AK000179 AK308731
RefSeq transcript (Entrez)NM_001130067 NM_001302692 NM_001302693 NM_001302694 NM_001351054 NM_001351055 NM_001351056 NM_001351057 NM_015271
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRIM2
Cluster EST : UnigeneHs.435711 [ NCBI ]
CGAP (NCI)Hs.435711
Alternative Splicing GalleryENSG00000109654
Gene ExpressionTRIM2 [ NCBI-GEO ]   TRIM2 [ EBI - ARRAY_EXPRESS ]   TRIM2 [ SEEK ]   TRIM2 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23321
GTEX Portal (Tissue expression)TRIM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C040   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C040  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C040
Splice isoforms : SwissVarQ9C040
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ9C040
Domaine pattern : Prosite (Expaxy)FILAMIN_REPEAT (PS50194)    NHL (PS51125)    ZF_BBOX (PS50119)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)6-blade_b-propeller_TolB-like    Bbox_C    Filamin/ABP280_repeat-like    Filamin/ABP280_rpt    Ig-like_fold    Ig_E-set    NHL_repeat    NHL_repeat_subgr    Znf-RING_LisH    Znf_B-box    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)Filamin (PF00630)    NHL (PF01436)    zf-B_box (PF00643)    zf-RING_UBOX (PF13445)   
Domain families : Pfam (NCBI)pfam00630    pfam01436    pfam00643    pfam13445   
Domain families : Smart (EMBL)BBC (SM00502)  BBOX (SM00336)  IG_FLMN (SM00557)  RING (SM00184)  
Conserved Domain (NCBI)TRIM2
DMDM Disease mutations23321
Blocks (Seattle)TRIM2
SuperfamilyQ9C040
Human Protein AtlasENSG00000109654
Peptide AtlasQ9C040
HPRD10279
IPIIPI00153011   IPI00910066   IPI00925733   IPI00925966   
Protein Interaction databases
DIP (DOE-UCLA)Q9C040
IntAct (EBI)Q9C040
FunCoupENSG00000109654
BioGRIDTRIM2
STRING (EMBL)TRIM2
ZODIACTRIM2
Ontologies - Pathways
QuickGOQ9C040
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  cytoplasm  zinc ion binding  protein ubiquitination  regulation of neuron apoptotic process  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  cytoplasm  zinc ion binding  protein ubiquitination  regulation of neuron apoptotic process  
NDEx NetworkTRIM2
Atlas of Cancer Signalling NetworkTRIM2
Wikipedia pathwaysTRIM2
Orthology - Evolution
OrthoDB23321
GeneTree (enSembl)ENSG00000109654
Phylogenetic Trees/Animal Genes : TreeFamTRIM2
HOVERGENQ9C040
HOGENOMQ9C040
Homologs : HomoloGeneTRIM2
Homology/Alignments : Family Browser (UCSC)TRIM2
Gene fusions - Rearrangements
Fusion: TCGATRIM2 ARFIP1
Fusion: TCGATRIM2 WDR37
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM2
dbVarTRIM2
ClinVarTRIM2
1000_GenomesTRIM2 
Exome Variant ServerTRIM2
ExAC (Exome Aggregation Consortium)TRIM2 (select the gene name)
Genetic variants : HAPMAP23321
Genomic Variants (DGV)TRIM2 [DGVbeta]
DECIPHERTRIM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIM2 
Mutations
ICGC Data PortalTRIM2 
TCGA Data PortalTRIM2 
Broad Tumor PortalTRIM2
OASIS PortalTRIM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRIM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIM2
DgiDB (Drug Gene Interaction Database)TRIM2
DoCM (Curated mutations)TRIM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIM2 (select a term)
intoGenTRIM2
Cancer3DTRIM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614141    615490   
Orphanet22714   
MedgenTRIM2
Genetic Testing Registry TRIM2
NextProtQ9C040 [Medical]
TSGene23321
GENETestsTRIM2
Huge Navigator TRIM2 [HugePedia]
snp3D : Map Gene to Disease23321
BioCentury BCIQTRIM2
ClinGenTRIM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23321
Chemical/Pharm GKB GenePA38070
Clinical trialTRIM2
Miscellaneous
canSAR (ICR)TRIM2 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIM2
EVEXTRIM2
GoPubMedTRIM2
iHOPTRIM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:59:34 CEST 2017

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