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TRIM21 (tripartite motif containing 21)

Identity

Alias_namesSSA1
Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)
tripartite motif-containing 21
Alias_symbol (synonym)RNF81
RO52
Ro/SSA
Other aliasSSA
HGNC (Hugo) TRIM21
LocusID (NCBI) 6737
Atlas_Id 46025
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 4384897 and ends at 4393696 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRIM21   11312
Cards
Entrez_Gene (NCBI)TRIM21  6737  tripartite motif containing 21
AliasesRNF81; RO52; Ro/SSA; SSA; 
SSA1
GeneCards (Weizmann)TRIM21
Ensembl hg19 (Hinxton)ENSG00000132109 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132109 [Gene_View]  chr11:4384897-4393696 [Contig_View]  TRIM21 [Vega]
ICGC DataPortalENSG00000132109
TCGA cBioPortalTRIM21
AceView (NCBI)TRIM21
Genatlas (Paris)TRIM21
WikiGenes6737
SOURCE (Princeton)TRIM21
Genetics Home Reference (NIH)TRIM21
Genomic and cartography
GoldenPath hg38 (UCSC)TRIM21  -     chr11:4384897-4393696 -  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIM21  -     11p15.4   [Description]    (hg19-Feb_2009)
EnsemblTRIM21 - 11p15.4 [CytoView hg19]  TRIM21 - 11p15.4 [CytoView hg38]
Mapping of homologs : NCBITRIM21 [Mapview hg19]  TRIM21 [Mapview hg38]
OMIM109092   
Gene and transcription
Genbank (Entrez)AK225564 AW575137 AY742713 BC010861 BP280435
RefSeq transcript (Entrez)NM_003141
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRIM21
Cluster EST : UnigeneHs.532357 [ NCBI ]
CGAP (NCI)Hs.532357
Alternative Splicing GalleryENSG00000132109
Gene ExpressionTRIM21 [ NCBI-GEO ]   TRIM21 [ EBI - ARRAY_EXPRESS ]   TRIM21 [ SEEK ]   TRIM21 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6737
GTEX Portal (Tissue expression)TRIM21
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19474   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19474  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19474
Splice isoforms : SwissVarP19474
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusP19474
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    ZF_BBOX (PS50119)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)B30.2/SPRY    Butyrophylin    ConA-like_dom    PRY    SPRY_dom    Ubox_domain    Znf_B-box    Znf_B-box_chordata    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)PRY (PF13765)    SPRY (PF00622)    zf-B_box (PF00643)   
Domain families : Pfam (NCBI)pfam13765    pfam00622    pfam00643   
Domain families : Smart (EMBL)BBOX (SM00336)  PRY (SM00589)  RING (SM00184)  SPRY (SM00449)  Ubox (SM00504)  
Conserved Domain (NCBI)TRIM21
DMDM Disease mutations6737
Blocks (Seattle)TRIM21
PDB (SRS)2IWG   
PDB (PDBSum)2IWG   
PDB (IMB)2IWG   
PDB (RSDB)2IWG   
Structural Biology KnowledgeBase2IWG   
SCOP (Structural Classification of Proteins)2IWG   
CATH (Classification of proteins structures)2IWG   
SuperfamilyP19474
Human Protein AtlasENSG00000132109
Peptide AtlasP19474
HPRD00170
IPIIPI00018971   IPI00969571   IPI01012950   IPI00979284   
Protein Interaction databases
DIP (DOE-UCLA)P19474
IntAct (EBI)P19474
FunCoupENSG00000132109
BioGRIDTRIM21
STRING (EMBL)TRIM21
ZODIACTRIM21
Ontologies - Pathways
QuickGOP19474
Ontology : AmiGOprotein polyubiquitination  protein polyubiquitination  P-body  DNA binding  RNA binding  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  autophagosome  cytosol  protein monoubiquitination  cell cycle  zinc ion binding  positive regulation of autophagy  protein ubiquitination  SCF ubiquitin ligase complex  intracellular ribonucleoprotein complex  cytoplasmic vesicle  protein destabilization  negative regulation of NF-kappaB transcription factor activity  regulation of type I interferon production  negative regulation of viral transcription  response to interferon-gamma  identical protein binding  innate immune response  positive regulation of cell cycle  positive regulation of viral entry into host cell  positive regulation of sequence-specific DNA binding transcription factor activity  protein autoubiquitination  interferon-gamma-mediated signaling pathway  protein trimerization  negative regulation of protein deubiquitination  negative regulation of viral release from host cell  
Ontology : EGO-EBIprotein polyubiquitination  protein polyubiquitination  P-body  DNA binding  RNA binding  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  autophagosome  cytosol  protein monoubiquitination  cell cycle  zinc ion binding  positive regulation of autophagy  protein ubiquitination  SCF ubiquitin ligase complex  intracellular ribonucleoprotein complex  cytoplasmic vesicle  protein destabilization  negative regulation of NF-kappaB transcription factor activity  regulation of type I interferon production  negative regulation of viral transcription  response to interferon-gamma  identical protein binding  innate immune response  positive regulation of cell cycle  positive regulation of viral entry into host cell  positive regulation of sequence-specific DNA binding transcription factor activity  protein autoubiquitination  interferon-gamma-mediated signaling pathway  protein trimerization  negative regulation of protein deubiquitination  negative regulation of viral release from host cell  
Pathways : KEGGSystemic lupus erythematosus   
NDEx NetworkTRIM21
Atlas of Cancer Signalling NetworkTRIM21
Wikipedia pathwaysTRIM21
Orthology - Evolution
OrthoDB6737
GeneTree (enSembl)ENSG00000132109
Phylogenetic Trees/Animal Genes : TreeFamTRIM21
HOVERGENP19474
HOGENOMP19474
Homologs : HomoloGeneTRIM21
Homology/Alignments : Family Browser (UCSC)TRIM21
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM21
dbVarTRIM21
ClinVarTRIM21
1000_GenomesTRIM21 
Exome Variant ServerTRIM21
ExAC (Exome Aggregation Consortium)TRIM21 (select the gene name)
Genetic variants : HAPMAP6737
Genomic Variants (DGV)TRIM21 [DGVbeta]
DECIPHERTRIM21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIM21 
Mutations
ICGC Data PortalTRIM21 
TCGA Data PortalTRIM21 
Broad Tumor PortalTRIM21
OASIS PortalTRIM21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRIM21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIM21
DgiDB (Drug Gene Interaction Database)TRIM21
DoCM (Curated mutations)TRIM21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIM21 (select a term)
intoGenTRIM21
Cancer3DTRIM21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109092   
Orphanet
MedgenTRIM21
Genetic Testing Registry TRIM21
NextProtP19474 [Medical]
TSGene6737
GENETestsTRIM21
Target ValidationTRIM21
Huge Navigator TRIM21 [HugePedia]
snp3D : Map Gene to Disease6737
BioCentury BCIQTRIM21
ClinGenTRIM21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6737
Chemical/Pharm GKB GenePA36136
Clinical trialTRIM21
Miscellaneous
canSAR (ICR)TRIM21 (select the gene name)
Probes
Litterature
PubMed136 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIM21
EVEXTRIM21
GoPubMedTRIM21
iHOPTRIM21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 13:00:48 CEST 2017

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