TRIM22 (tripartite motif containing 22)

2010-03-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
GPSTAF50,RNF94,STAF50
FUSION GENES

Other Information

Locus ID:

NCBI: 10346
MIM: 606559
HGNC: 16379
Ensembl: ENSG00000132274

Variants:

dbSNP: 10346
ClinVar: 10346
TCGA: ENSG00000132274
COSMIC: TRIM22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132274ENST00000379965Q8IYM9
ENSG00000132274ENST00000414641C9JIU5
ENSG00000132274ENST00000414897H7BZD3
ENSG00000132274ENST00000425490C9J060
ENSG00000132274ENST00000429063H7C376
ENSG00000132274ENST00000444844H7C262
ENSG00000132274ENST00000450670H7C2K0
ENSG00000132274ENST00000454828C9JWC5

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183890792008The interferon response inhibits HIV particle production by induction of TRIM22.115
195856482009Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain.67
234086072013TRIM22 inhibits influenza A virus infection by targeting the viral nucleoprotein for degradation.67
199022552010Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes.53
192181982009TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus.50
213459492011TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements.49
200017302010Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination.39
256836092016Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A.34
209805242011Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection.32
169260432006Stimulated trans-acting factor of 50 kDa (Staf50) inhibits HIV-1 replication in human monocyte-derived macrophages.31

Citation

Dessen P

TRIM22 (tripartite motif containing 22)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51401/trim22