Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TRIM22 (tripartite motif containing 22)

Identity

Alias_namestripartite motif-containing 22
Alias_symbol (synonym)STAF50
GPSTAF50
RNF94
Other alias
HGNC (Hugo) TRIM22
LocusID (NCBI) 10346
Atlas_Id 51401
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 5689587 and ends at 5710863 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AP2A2 (11p15.5) / TRIM22 (11p15.4)HBG2 (11p15.4) / TRIM22 (11p15.4)AP2A2 11p15.5 / TRIM22 11p15.4
HBG2 11p15.4 / TRIM22 11p15.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;11)(p15;p15) AP2A2/TRIM22
t(11;11)(p15;p15) HBG2/TRIM22

External links

Nomenclature
HGNC (Hugo)TRIM22   16379
Cards
Entrez_Gene (NCBI)TRIM22  10346  tripartite motif containing 22
AliasesGPSTAF50; RNF94; STAF50
GeneCards (Weizmann)TRIM22
Ensembl hg19 (Hinxton)ENSG00000132274 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132274 [Gene_View]  ENSG00000132274 [Sequence]  chr11:5689587-5710863 [Contig_View]  TRIM22 [Vega]
ICGC DataPortalENSG00000132274
TCGA cBioPortalTRIM22
AceView (NCBI)TRIM22
Genatlas (Paris)TRIM22
WikiGenes10346
SOURCE (Princeton)TRIM22
Genetics Home Reference (NIH)TRIM22
Genomic and cartography
GoldenPath hg38 (UCSC)TRIM22  -     chr11:5689587-5710863 +  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIM22  -     11p15.4   [Description]    (hg19-Feb_2009)
EnsemblTRIM22 - 11p15.4 [CytoView hg19]  TRIM22 - 11p15.4 [CytoView hg38]
Mapping of homologs : NCBITRIM22 [Mapview hg19]  TRIM22 [Mapview hg38]
OMIM606559   
Gene and transcription
Genbank (Entrez)AK290434 AK298715 AK298934 AK301192 AK308221
RefSeq transcript (Entrez)NM_001199573 NM_006074
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRIM22
Cluster EST : UnigeneHs.733231 [ NCBI ]
CGAP (NCI)Hs.733231
Alternative Splicing GalleryENSG00000132274
Gene ExpressionTRIM22 [ NCBI-GEO ]   TRIM22 [ EBI - ARRAY_EXPRESS ]   TRIM22 [ SEEK ]   TRIM22 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM22 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10346
GTEX Portal (Tissue expression)TRIM22
Human Protein AtlasENSG00000132274-TRIM22 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IYM9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IYM9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IYM9
Splice isoforms : SwissVarQ8IYM9
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ8IYM9
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    ZF_BBOX (PS50119)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)B30.2/SPRY    Butyrophylin    ConA-like_dom    SPRY_dom    Znf-RING_LisH    Znf_B-box    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)SPRY (PF00622)    zf-B_box (PF00643)    zf-RING_UBOX (PF13445)   
Domain families : Pfam (NCBI)pfam00622    pfam00643    pfam13445   
Domain families : Smart (EMBL)BBOX (SM00336)  RING (SM00184)  SPRY (SM00449)  
Conserved Domain (NCBI)TRIM22
DMDM Disease mutations10346
Blocks (Seattle)TRIM22
SuperfamilyQ8IYM9
Human Protein Atlas [tissue]ENSG00000132274-TRIM22 [tissue]
Peptide AtlasQ8IYM9
HPRD05951
IPIIPI00477812   IPI00477398   IPI00942007   IPI00748802   IPI00239700   IPI00884241   IPI00657693   IPI00893225   IPI00927497   IPI00927753   IPI00924480   
Protein Interaction databases
DIP (DOE-UCLA)Q8IYM9
IntAct (EBI)Q8IYM9
FunCoupENSG00000132274
BioGRIDTRIM22
STRING (EMBL)TRIM22
ZODIACTRIM22
Ontologies - Pathways
QuickGOQ8IYM9
Ontology : AmiGODNA binding transcription factor activity  transcription corepressor activity  protein binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  immune response  zinc ion binding  response to virus  positive regulation of autophagy  Cajal body  viral process  protein ubiquitination  nuclear body  nuclear speck  transferase activity  protein kinase binding  protein binding, bridging  regulation of protein localization  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  defense response to virus  interferon-gamma-mediated signaling pathway  protein trimerization  negative regulation of nucleic acid-templated transcription  
Ontology : EGO-EBIDNA binding transcription factor activity  transcription corepressor activity  protein binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  immune response  zinc ion binding  response to virus  positive regulation of autophagy  Cajal body  viral process  protein ubiquitination  nuclear body  nuclear speck  transferase activity  protein kinase binding  protein binding, bridging  regulation of protein localization  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  defense response to virus  interferon-gamma-mediated signaling pathway  protein trimerization  negative regulation of nucleic acid-templated transcription  
NDEx NetworkTRIM22
Atlas of Cancer Signalling NetworkTRIM22
Wikipedia pathwaysTRIM22
Orthology - Evolution
OrthoDB10346
GeneTree (enSembl)ENSG00000132274
Phylogenetic Trees/Animal Genes : TreeFamTRIM22
HOVERGENQ8IYM9
HOGENOMQ8IYM9
Homologs : HomoloGeneTRIM22
Homology/Alignments : Family Browser (UCSC)TRIM22
Gene fusions - Rearrangements
Fusion : MitelmanAP2A2/TRIM22 [11p15.5/11p15.4]  [t(11;11)(p15;p15)]  
Fusion : MitelmanHBG2/TRIM22 [11p15.4/11p15.4]  [t(11;11)(p15;p15)]  
Fusion PortalAP2A2 11p15.5 TRIM22 11p15.4 HNSC
Fusion PortalHBG2 11p15.4 TRIM22 11p15.4 HNSC
Fusion : QuiverTRIM22
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM22 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM22
dbVarTRIM22
ClinVarTRIM22
1000_GenomesTRIM22 
Exome Variant ServerTRIM22
ExAC (Exome Aggregation Consortium)ENSG00000132274
GNOMAD BrowserENSG00000132274
Genetic variants : HAPMAP10346
Genomic Variants (DGV)TRIM22 [DGVbeta]
DECIPHERTRIM22 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIM22 
Mutations
ICGC Data PortalTRIM22 
TCGA Data PortalTRIM22 
Broad Tumor PortalTRIM22
OASIS PortalTRIM22 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM22  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRIM22
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIM22
DgiDB (Drug Gene Interaction Database)TRIM22
DoCM (Curated mutations)TRIM22 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIM22 (select a term)
intoGenTRIM22
Cancer3DTRIM22(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606559   
Orphanet
DisGeNETTRIM22
MedgenTRIM22
Genetic Testing Registry TRIM22
NextProtQ8IYM9 [Medical]
TSGene10346
GENETestsTRIM22
Target ValidationTRIM22
Huge Navigator TRIM22 [HugePedia]
snp3D : Map Gene to Disease10346
BioCentury BCIQTRIM22
ClinGenTRIM22
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10346
Chemical/Pharm GKB GenePA38129
Clinical trialTRIM22
Miscellaneous
canSAR (ICR)TRIM22 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIM22
EVEXTRIM22
GoPubMedTRIM22
iHOPTRIM22
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:55:18 CEST 2018
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