TRIM23 (tripartite motif containing 23)

2014-01-01  

Identity

HGNC
TRIM23
LOCATION
5q12.3
LOCUSID
373
ALIAS
ARD1,ARFD1,RNF46

Other Information

Locus ID:

NCBI: 373
MIM: 601747
HGNC: 660
Ensembl: ENSG00000113595

Variants:

dbSNP: 373
ClinVar: 373
TCGA: ENSG00000113595
COSMIC: TRIM23

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113595ENST00000231524P36406
ENSG00000113595ENST00000274327P36406
ENSG00000113595ENST00000381018P36406
ENSG00000113595ENST00000505205D6RBN4
ENSG00000113595ENST00000506400D6RD22
ENSG00000113595ENST00000513794D6R9E9

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
207246602010Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense.66
191766152009Identification of TRIM23 as a cofactor involved in the regulation of NF-kappaB by human cytomegalovirus.33
288710902017TRIM23 mediates virus-induced autophagy via activation of TBK1.33
156840772005E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1).18
259056702015The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ.18
286814142017Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase.11
311897042019Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy.7
304776422018Elevated TRIM23 expression predicts poor prognosis in Chinese gastric cancer.5
316773352020Elevated TRIM23 expression predicts cisplatin resistance in lung adenocarcinoma.3
308477452019TRIM27 Promotes Hepatitis C Virus Replication by Suppressing Type I Interferon Response.1

Citation

Dessen P

TRIM23 (tripartite motif containing 23)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53772/trim23