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TRIM25 (tripartite motif containing 25)

Identity

Alias_namesZNF147
zinc finger protein 147 (estrogen-responsive finger protein)
tripartite motif-containing 25
Alias_symbol (synonym)EFP
RNF147
Other aliasZ147
HGNC (Hugo) TRIM25
LocusID (NCBI) 7706
Atlas_Id 42698
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 54965270 and ends at 54991409 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACBD4 (17q21.31) / TRIM25 (17q22)PLXNB2 (22q13.33) / TRIM25 (17q22)TRIM25 (17q22) / HYOU1 (11q23.3)
TRIM25 (17q22) / LPCAT1 (5p15.33)TRIM25 (17q22) / MSI2 (17q22)TRIM25 (17q22) / TBX4 (17q23.2)
TRIM25 (17q22) / TRIM25 (17q22)ZNF664 (12q24.31) / TRIM25 (17q22)TRIM25 17q22 / MSI2 17q22
TRIM25 17q22 / TBX4 17q23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRIM25   12932
Cards
Entrez_Gene (NCBI)TRIM25  7706  tripartite motif containing 25
AliasesEFP; RNF147; Z147; ZNF147
GeneCards (Weizmann)TRIM25
Ensembl hg19 (Hinxton)ENSG00000121060 [Gene_View]  chr17:54965270-54991409 [Contig_View]  TRIM25 [Vega]
Ensembl hg38 (Hinxton)ENSG00000121060 [Gene_View]  chr17:54965270-54991409 [Contig_View]  TRIM25 [Vega]
ICGC DataPortalENSG00000121060
TCGA cBioPortalTRIM25
AceView (NCBI)TRIM25
Genatlas (Paris)TRIM25
WikiGenes7706
SOURCE (Princeton)TRIM25
Genetics Home Reference (NIH)TRIM25
Genomic and cartography
GoldenPath hg19 (UCSC)TRIM25  -     chr17:54965270-54991409 -  17q22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TRIM25  -     17q22   [Description]    (hg38-Dec_2013)
EnsemblTRIM25 - 17q22 [CytoView hg19]  TRIM25 - 17q22 [CytoView hg38]
Mapping of homologs : NCBITRIM25 [Mapview hg19]  TRIM25 [Mapview hg38]
OMIM600453   
Gene and transcription
Genbank (Entrez)AB208994 AK024597 AK310720 BC013752 BC016924
RefSeq transcript (Entrez)NM_005082
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)TRIM25
Cluster EST : UnigeneHs.528952 [ NCBI ]
CGAP (NCI)Hs.528952
Alternative Splicing GalleryENSG00000121060
Gene ExpressionTRIM25 [ NCBI-GEO ]   TRIM25 [ EBI - ARRAY_EXPRESS ]   TRIM25 [ SEEK ]   TRIM25 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM25 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7706
GTEX Portal (Tissue expression)TRIM25
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14258   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14258  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14258
Splice isoforms : SwissVarQ14258
PhosPhoSitePlusQ14258
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)B30.2/SPRY    Butyrophylin    ConA-like_dom    PRY    SPRY_dom    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)PRY (PF13765)    SPRY (PF00622)   
Domain families : Pfam (NCBI)pfam13765    pfam00622   
Domain families : Smart (EMBL)PRY (SM00589)  RING (SM00184)  SPRY (SM00449)  
Conserved Domain (NCBI)TRIM25
DMDM Disease mutations7706
Blocks (Seattle)TRIM25
PDB (SRS)4CFG   
PDB (PDBSum)4CFG   
PDB (IMB)4CFG   
PDB (RSDB)4CFG   
Structural Biology KnowledgeBase4CFG   
SCOP (Structural Classification of Proteins)4CFG   
CATH (Classification of proteins structures)4CFG   
SuperfamilyQ14258
Human Protein AtlasENSG00000121060
Peptide AtlasQ14258
HPRD02711
IPIIPI00029629   
Protein Interaction databases
DIP (DOE-UCLA)Q14258
IntAct (EBI)Q14258
FunCoupENSG00000121060
BioGRIDTRIM25
STRING (EMBL)TRIM25
ZODIACTRIM25
Ontologies - Pathways
QuickGOQ14258
Ontology : AmiGOtranscription factor activity, sequence-specific DNA binding  ubiquitin-protein transferase activity  protein binding  nucleoplasm  nucleoplasm  cytoplasm  cytosol  protein monoubiquitination  zinc ion binding  viral process  acid-amino acid ligase activity  translesion synthesis  negative regulation of type I interferon production  ERAD pathway  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to estrogen  poly(A) RNA binding  innate immune response  innate immune response  regulation of viral entry into host cell  negative regulation of viral entry into host cell  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  defense response to virus  interferon-gamma-mediated signaling pathway  regulation of viral release from host cell  negative regulation of viral release from host cell  ubiquitin protein ligase activity involved in ERAD pathway  
Ontology : EGO-EBItranscription factor activity, sequence-specific DNA binding  ubiquitin-protein transferase activity  protein binding  nucleoplasm  nucleoplasm  cytoplasm  cytosol  protein monoubiquitination  zinc ion binding  viral process  acid-amino acid ligase activity  translesion synthesis  negative regulation of type I interferon production  ERAD pathway  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to estrogen  poly(A) RNA binding  innate immune response  innate immune response  regulation of viral entry into host cell  negative regulation of viral entry into host cell  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  defense response to virus  interferon-gamma-mediated signaling pathway  regulation of viral release from host cell  negative regulation of viral release from host cell  ubiquitin protein ligase activity involved in ERAD pathway  
Pathways : BIOCARTAEstrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]   
Pathways : KEGGNF-kappa B signaling pathway    RIG-I-like receptor signaling pathway    Influenza A   
NDEx NetworkTRIM25
Atlas of Cancer Signalling NetworkTRIM25
Wikipedia pathwaysTRIM25
Orthology - Evolution
OrthoDB7706
GeneTree (enSembl)ENSG00000121060
Phylogenetic Trees/Animal Genes : TreeFamTRIM25
HOVERGENQ14258
HOGENOMQ14258
Homologs : HomoloGeneTRIM25
Homology/Alignments : Family Browser (UCSC)TRIM25
Gene fusions - Rearrangements
Fusion : MitelmanTRIM25/TBX4 [17q22/17q23.2]  
Fusion: TCGATRIM25 17q22 MSI2 17q22 BRCA
Fusion: TCGATRIM25 17q22 TBX4 17q23.2 BRCA
Fusion Cancer (Beijing)ACBD4 [17q21.31]  -  TRIM25 [17q22]  [FUSC004657]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM25 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM25
dbVarTRIM25
ClinVarTRIM25
1000_GenomesTRIM25 
Exome Variant ServerTRIM25
ExAC (Exome Aggregation Consortium)TRIM25 (select the gene name)
Genetic variants : HAPMAP7706
Genomic Variants (DGV)TRIM25 [DGVbeta]
DECIPHER (Syndromes)17:54965270-54991409  ENSG00000121060
CONAN: Copy Number AnalysisTRIM25 
Mutations
ICGC Data PortalTRIM25 
TCGA Data PortalTRIM25 
Broad Tumor PortalTRIM25
OASIS PortalTRIM25 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM25  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRIM25
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIM25
DgiDB (Drug Gene Interaction Database)TRIM25
DoCM (Curated mutations)TRIM25 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIM25 (select a term)
intoGenTRIM25
Cancer3DTRIM25(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600453   
Orphanet
MedgenTRIM25
Genetic Testing Registry TRIM25
NextProtQ14258 [Medical]
TSGene7706
GENETestsTRIM25
Huge Navigator TRIM25 [HugePedia]
snp3D : Map Gene to Disease7706
BioCentury BCIQTRIM25
ClinGenTRIM25
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7706
Chemical/Pharm GKB GenePA37519
Clinical trialTRIM25
Miscellaneous
canSAR (ICR)TRIM25 (select the gene name)
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIM25
EVEXTRIM25
GoPubMedTRIM25
iHOPTRIM25
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:32:17 CET 2017

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