TRIM25 (tripartite motif containing 25)

2003-02-01  

Identity

HGNC
LOCATION
17q22
LOCUSID
ALIAS
EFP,RNF147,Z147,ZNF147
FUSION GENES

Other Information

Locus ID:

NCBI: 7706
MIM: 600453
HGNC: 12932
Ensembl: ENSG00000121060

Variants:

dbSNP: 7706
ClinVar: 7706
TCGA: ENSG00000121060
COSMIC: TRIM25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121060ENST00000316881Q14258
ENSG00000121060ENST00000537230Q14258
ENSG00000121060ENST00000572021I3L2W4
ENSG00000121060ENST00000648772A0A3B3IUA7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
Influenza AKEGGko05164
Influenza AKEGGhsa05164
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF3-dependent IRF activation pathwayREACTOMER-HSA-918233
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10REACTOMER-HSA-933543
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541
TRAF6 mediated NF-kB activationREACTOMER-HSA-933542
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Termination of translesion DNA synthesisREACTOMER-HSA-5656169
DeubiquitinationREACTOMER-HSA-5688426
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194543482009Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.352
261381032015Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness.131
189485942008Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction.104
226078052012The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.85
212921672011Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction.75
212665482011Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.68
226260582012MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors.66
243992972014The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25.56
271542062016Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.48
281487872017The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination.45

Citation

Dessen P

TRIM25 (tripartite motif containing 25)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42698/trim25