TRIM28 (tripartite motif containing 28)

2003-08-01  

Identity

HGNC
TRIM28
LOCATION
19q13.43
LOCUSID
10155
ALIAS
KAP1,PPP1R157,RNF96,TF1B,TIF1B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10155
MIM: 601742
HGNC: 16384
Ensembl: ENSG00000130726

Variants:

dbSNP: 10155
ClinVar: 10155
TCGA: ENSG00000130726
COSMIC: TRIM28

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130726ENST00000253024Q13263
ENSG00000130726ENST00000341753Q13263
ENSG00000130726ENST00000593582M0R2I3
ENSG00000130726ENST00000594806M0R3C0
ENSG00000130726ENST00000597136M0R0K9
ENSG00000130726ENST00000597968M0QZE6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
20081839201053BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.138
216527162011KAP1 protein: an enigmatic master regulator of the genome.137
202212602010KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading.134
169543812006The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression.130
175426502007Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs.103
161078762005MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.84
211703382010ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes.82
179423932007Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression.81
171788522006KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions.64
213433392011Functional analysis of KAP1 genomic recruitment.61

Citation

Dessen P

TRIM28 (tripartite motif containing 28)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42700/trim28