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TRIM28 (tripartite motif containing 28)

Identity

Alias_namesregulatory subunit 157
Alias_symbol (synonym)TIF1B
KAP1
TF1B
RNF96
PPP1R157
Other alias
HGNC (Hugo) TRIM28
LocusID (NCBI) 10155
Atlas_Id 42700
Location 19q13.43  [Link to chromosome band 19q13]
Location_base_pair Starts at 59055836 and ends at 59062082 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CAPZA2 (7q31.2) / TRIM28 (19q13.43)SNRPF (12q23.1) / TRIM28 (19q13.43)TRIM28 (19q13.43) / TRIM28 (19q13.43)
TRIM28 (19q13.43) / ZBTB45 (19q13.43)TRIM28 19q13.43 / ZBTB45 19q13.43

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRIM28   16384
Cards
Entrez_Gene (NCBI)TRIM28  10155  tripartite motif containing 28
AliasesKAP1; PPP1R157; RNF96; TF1B; 
TIF1B
GeneCards (Weizmann)TRIM28
Ensembl hg19 (Hinxton)ENSG00000130726 [Gene_View]  chr19:59055836-59062082 [Contig_View]  TRIM28 [Vega]
Ensembl hg38 (Hinxton)ENSG00000130726 [Gene_View]  chr19:59055836-59062082 [Contig_View]  TRIM28 [Vega]
ICGC DataPortalENSG00000130726
TCGA cBioPortalTRIM28
AceView (NCBI)TRIM28
Genatlas (Paris)TRIM28
WikiGenes10155
SOURCE (Princeton)TRIM28
Genetics Home Reference (NIH)TRIM28
Genomic and cartography
GoldenPath hg19 (UCSC)TRIM28  -     chr19:59055836-59062082 +  19q13.43   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TRIM28  -     19q13.43   [Description]    (hg38-Dec_2013)
EnsemblTRIM28 - 19q13.43 [CytoView hg19]  TRIM28 - 19q13.43 [CytoView hg38]
Mapping of homologs : NCBITRIM28 [Mapview hg19]  TRIM28 [Mapview hg38]
OMIM601742   
Gene and transcription
Genbank (Entrez)AK131063 AK225760 AK313478 AL360114 AL360188
RefSeq transcript (Entrez)NM_005762
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)TRIM28
Cluster EST : UnigeneHs.467408 [ NCBI ]
CGAP (NCI)Hs.467408
Alternative Splicing GalleryENSG00000130726
Gene ExpressionTRIM28 [ NCBI-GEO ]   TRIM28 [ EBI - ARRAY_EXPRESS ]   TRIM28 [ SEEK ]   TRIM28 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM28 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10155
GTEX Portal (Tissue expression)TRIM28
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13263   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13263  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13263
Splice isoforms : SwissVarQ13263
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ13263
Domaine pattern : Prosite (Expaxy)ZF_BBOX (PS50119)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Bbox_C    Bromodomain    Zinc_finger_PHD-type_CS    Znf_B-box    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)PHD (PF00628)    zf-B_box (PF00643)    zf-RING_5 (PF14634)   
Domain families : Pfam (NCBI)pfam00628    pfam00643    pfam14634   
Domain families : Smart (EMBL)BBC (SM00502)  BBOX (SM00336)  BROMO (SM00297)  PHD (SM00249)  RING (SM00184)  
Conserved Domain (NCBI)TRIM28
DMDM Disease mutations10155
Blocks (Seattle)TRIM28
PDB (SRS)1FP0    2RO1    2YVR   
PDB (PDBSum)1FP0    2RO1    2YVR   
PDB (IMB)1FP0    2RO1    2YVR   
PDB (RSDB)1FP0    2RO1    2YVR   
Structural Biology KnowledgeBase1FP0    2RO1    2YVR   
SCOP (Structural Classification of Proteins)1FP0    2RO1    2YVR   
CATH (Classification of proteins structures)1FP0    2RO1    2YVR   
SuperfamilyQ13263
Human Protein AtlasENSG00000130726
Peptide AtlasQ13263
HPRD03445
IPIIPI00438229   IPI00438230   
Protein Interaction databases
DIP (DOE-UCLA)Q13263
IntAct (EBI)Q13263
FunCoupENSG00000130726
BioGRIDTRIM28
STRING (EMBL)TRIM28
ZODIACTRIM28
Ontologies - Pathways
QuickGOQ13263
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription coactivator activity  epithelial to mesenchymal transition  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein kinase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nuclear euchromatin  nuclear heterochromatin  DNA repair  transcription initiation from RNA polymerase II promoter  Ras protein signal transduction  embryo implantation  zinc ion binding  protein ubiquitination  chromatin modification  ligase activity  protein sumoylation  protein sumoylation  ubiquitin protein ligase binding  Krueppel-associated box domain binding  positive regulation of transcription factor import into nucleus  DNA methylation involved in embryo development  sequence-specific DNA binding  poly(A) RNA binding  innate immune response  positive regulation of DNA repair  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  protein oligomerization  convergent extension involved in axis elongation  embryonic placenta morphogenesis  chromo shadow domain binding  positive regulation of methylation-dependent chromatin silencing  RNA polymerase II transcription factor complex  negative regulation of DNA demethylation  negative regulation of viral release from host cell  promoter-specific chromatin binding  regulation of genetic imprinting  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription coactivator activity  epithelial to mesenchymal transition  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription corepressor activity  protein kinase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nuclear euchromatin  nuclear heterochromatin  DNA repair  transcription initiation from RNA polymerase II promoter  Ras protein signal transduction  embryo implantation  zinc ion binding  protein ubiquitination  chromatin modification  ligase activity  protein sumoylation  protein sumoylation  ubiquitin protein ligase binding  Krueppel-associated box domain binding  positive regulation of transcription factor import into nucleus  DNA methylation involved in embryo development  sequence-specific DNA binding  poly(A) RNA binding  innate immune response  positive regulation of DNA repair  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  protein oligomerization  convergent extension involved in axis elongation  embryonic placenta morphogenesis  chromo shadow domain binding  positive regulation of methylation-dependent chromatin silencing  RNA polymerase II transcription factor complex  negative regulation of DNA demethylation  negative regulation of viral release from host cell  promoter-specific chromatin binding  regulation of genetic imprinting  
NDEx NetworkTRIM28
Atlas of Cancer Signalling NetworkTRIM28
Wikipedia pathwaysTRIM28
Orthology - Evolution
OrthoDB10155
GeneTree (enSembl)ENSG00000130726
Phylogenetic Trees/Animal Genes : TreeFamTRIM28
HOVERGENQ13263
HOGENOMQ13263
Homologs : HomoloGeneTRIM28
Homology/Alignments : Family Browser (UCSC)TRIM28
Gene fusions - Rearrangements
Fusion : MitelmanCAPZA2/TRIM28 [7q31.2/19q13.43]  [t(7;19)(q31;q13)]  
Fusion : MitelmanTRIM28/ZBTB45 [19q13.43/19q13.43]  [t(19;19)(q13;q13)]  
Fusion: TCGATRIM28 19q13.43 ZBTB45 19q13.43 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM28 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM28
dbVarTRIM28
ClinVarTRIM28
1000_GenomesTRIM28 
Exome Variant ServerTRIM28
ExAC (Exome Aggregation Consortium)TRIM28 (select the gene name)
Genetic variants : HAPMAP10155
Genomic Variants (DGV)TRIM28 [DGVbeta]
DECIPHER (Syndromes)19:59055836-59062082  ENSG00000130726
CONAN: Copy Number AnalysisTRIM28 
Mutations
ICGC Data PortalTRIM28 
TCGA Data PortalTRIM28 
Broad Tumor PortalTRIM28
OASIS PortalTRIM28 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM28  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRIM28
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIM28
DgiDB (Drug Gene Interaction Database)TRIM28
DoCM (Curated mutations)TRIM28 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIM28 (select a term)
intoGenTRIM28
Cancer3DTRIM28(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601742   
Orphanet
MedgenTRIM28
Genetic Testing Registry TRIM28
NextProtQ13263 [Medical]
TSGene10155
GENETestsTRIM28
Huge Navigator TRIM28 [HugePedia]
snp3D : Map Gene to Disease10155
BioCentury BCIQTRIM28
ClinGenTRIM28
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10155
Chemical/Pharm GKB GenePA38131
Clinical trialTRIM28
Miscellaneous
canSAR (ICR)TRIM28 (select the gene name)
Probes
Litterature
PubMed202 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIM28
EVEXTRIM28
GoPubMedTRIM28
iHOPTRIM28
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:23:26 CEST 2017

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