TRIM31 (tripartite motif containing 31)

2011-10-01  

Identity

HGNC
LOCATION
6p22.1
LOCUSID
ALIAS
C6orf13,HCG1,HCGI,RNF

Other Information

Locus ID:

NCBI: 11074
MIM: 609316
HGNC: 16289
Ensembl: ENSG00000204616

Variants:

dbSNP: 11074
ClinVar: 11074
TCGA: ENSG00000204616
COSMIC: TRIM31

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204616ENST00000376734Q9BZY9
ENSG00000204616ENST00000376734Q2L6J1

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
279290862016The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3.47
299307252018Oncogenic TRIM31 confers gemcitabine resistance in pancreatic cancer via activating the NF-κB signaling pathway.23
272169612016TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells.19
277432012016Downregulation of Foxo3 and TRIM31 by miR-551b in side population promotes cell proliferation, invasion, and drug resistance of ovarian cancer.18
289679072018TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiquitination of TSC1-TSC2 complex.18
255909992015The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex.15
245669002014TRIM31 is downregulated in non-small cell lung cancer and serves as a potential tumor suppressor.14
298649082018Knockdown of TRIM31 suppresses proliferation and invasion of gallbladder cancer cells by down-regulating MMP2/9 through the PI3K/Akt signaling pathway.13
212319122011The cellular level of TRIM31, an RBCC protein overexpressed in gastric cancer, is regulated by multiple mechanisms including the ubiquitin-proteasome system.11

Citation

Dessen P

TRIM31 (tripartite motif containing 31)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52447/trim31