TRIM32 (tripartite motif containing 32)

2003-05-01  

Identity

HGNC
LOCATION
9q33.1
LOCUSID
ALIAS
BBS11,HT2A,LGMD2H,LGMDR8,TATIP
FUSION GENES

Other Information

Locus ID:

NCBI: 22954
MIM: 602290
HGNC: 16380
Ensembl: ENSG00000119401

Variants:

dbSNP: 22954
ClinVar: 22954
TCGA: ENSG00000119401
COSMIC: TRIM32

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119401ENST00000373983Q13049
ENSG00000119401ENST00000373983A0A024R843
ENSG00000119401ENST00000411410Q5JVY0
ENSG00000119401ENST00000450136Q13049
ENSG00000119401ENST00000450136A0A024R843

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
Regulation of innate immune responses to cytosolic DNAREACTOMER-HSA-3134975

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
166068532006Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11).114
227451332012TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination.112
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
118220242002Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene.60
193493762009TRIM32 is an E3 ubiquitin ligase for dysbindin.52
271542062016Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.48
251469272014E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis.44
260576452015TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase.43
186326092008Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.42
243813042014Disruption of the ASTN2/TRIM32 locus at 9q33.1 is a risk factor in males for autism spectrum disorders, ADHD and other neurodevelopmental phenotypes.37

Citation

Dessen P

TRIM32 (tripartite motif containing 32)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42702/trim32