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TRIM33 (tripartite motif containing 33)

Identity

Alias (NCBI)ECTO
PTC7
RFG7
TF1G
TIF1G
TIF1GAMMA
TIFGAMMA
HGNC (Hugo) TRIM33
HGNC Alias symbTIF1GAMMA
FLJ11429
KIAA1113
TIFGAMMA
RFG7
TF1G
TIF1G
PTC7
HGNC Alias nametranscriptional intermediary factor 1 gamma
 ret-fused gene 7
HGNC Previous nametripartite motif-containing 33
LocusID (NCBI) 51592
Atlas_Id 502
Location 1p13.2  [Link to chromosome band 1p13]
Location_base_pair Starts at 114392793 and ends at 114511203 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AFF1 (4q21.3) / TRIM33 (1p13.2)POSTN (13q13.3) / TRIM33 (1p13.2)RET (10q11.21) / TRIM33 (1p13.2)
TRIM33 (1p13.2) / COL24A1 (1p22.3)TRIM33 (1p13.2) / COLEC12 (18p11.32)TRIM33 (1p13.2) / RET (10q11.21)
TRIM33 (1p13.2) / STK17B (2q32.3)TRIM33 (1p13.2) / TRIM33 (1p13.2)TRIM33 1p13.2 / RET 10q11.21
TRIM33 1p13.2 / COL24A1 1p22.3TRIM33 1p13.2 / RET 10q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Chronic Myelomonocytic Leukemia (CMML)


External links

 

Nomenclature
HGNC (Hugo)TRIM33   16290
Cards
Entrez_Gene (NCBI)TRIM33    tripartite motif containing 33
AliasesECTO; PTC7; RFG7; TF1G; 
TIF1G; TIF1GAMMA; TIFGAMMA
GeneCards (Weizmann)TRIM33
Ensembl hg19 (Hinxton)ENSG00000197323 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197323 [Gene_View]  ENSG00000197323 [Sequence]  chr1:114392793-114511203 [Contig_View]  TRIM33 [Vega]
ICGC DataPortalENSG00000197323
TCGA cBioPortalTRIM33
AceView (NCBI)TRIM33
Genatlas (Paris)TRIM33
SOURCE (Princeton)TRIM33
Genetics Home Reference (NIH)TRIM33
Genomic and cartography
GoldenPath hg38 (UCSC)TRIM33  -     chr1:114392793-114511203 -  1p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIM33  -     1p13.2   [Description]    (hg19-Feb_2009)
GoldenPathTRIM33 - 1p13.2 [CytoView hg19]  TRIM33 - 1p13.2 [CytoView hg38]
ImmunoBaseENSG00000197323
Genome Data Viewer NCBITRIM33 [Mapview hg19]  
OMIM605769   
Gene and transcription
Genbank (Entrez)AB029036 AB075517 AF119043 AF220136 AF220137
RefSeq transcript (Entrez)NM_015906 NM_033020
Consensus coding sequences : CCDS (NCBI)TRIM33
Gene ExpressionTRIM33 [ NCBI-GEO ]   TRIM33 [ EBI - ARRAY_EXPRESS ]   TRIM33 [ SEEK ]   TRIM33 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM33 [ Firebrowse - Broad ]
GenevisibleExpression of TRIM33 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51592
GTEX Portal (Tissue expression)TRIM33
Human Protein AtlasENSG00000197323-TRIM33 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UPN9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UPN9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UPN9
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UPN9
Domaine pattern : Prosite (Expaxy)BROMODOMAIN_2 (PS50014)    ZF_BBOX (PS50119)    ZF_PHD_1 (PS01359)    ZF_PHD_2 (PS50016)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Bbox_C    Bromodomain    Bromodomain-like_sf    Zinc_finger_PHD-type_CS    Znf-RING_LisH    Znf_B-box    Znf_FYVE_PHD    Znf_PHD    Znf_PHD-finger    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)Bromodomain (PF00439)    PHD (PF00628)    zf-B_box (PF00643)    zf-RING_UBOX (PF13445)   
Domain families : Pfam (NCBI)pfam00439    pfam00628    pfam00643    pfam13445   
Domain families : Smart (EMBL)BBC (SM00502)  BBOX (SM00336)  BROMO (SM00297)  PHD (SM00249)  RING (SM00184)  
Conserved Domain (NCBI)TRIM33
PDB (RSDB)3U5M    3U5N    3U5O    3U5P    5MR8   
PDB Europe3U5M    3U5N    3U5O    3U5P    5MR8   
PDB (PDBSum)3U5M    3U5N    3U5O    3U5P    5MR8   
PDB (IMB)3U5M    3U5N    3U5O    3U5P    5MR8   
Structural Biology KnowledgeBase3U5M    3U5N    3U5O    3U5P    5MR8   
SCOP (Structural Classification of Proteins)3U5M    3U5N    3U5O    3U5P    5MR8   
CATH (Classification of proteins structures)3U5M    3U5N    3U5O    3U5P    5MR8   
SuperfamilyQ9UPN9
AlphaFold pdb e-kbQ9UPN9   
Human Protein Atlas [tissue]ENSG00000197323-TRIM33 [tissue]
HPRD10423
Protein Interaction databases
DIP (DOE-UCLA)Q9UPN9
IntAct (EBI)Q9UPN9
BioGRIDTRIM33
STRING (EMBL)TRIM33
ZODIACTRIM33
Ontologies - Pathways
QuickGOQ9UPN9
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  DNA binding  protein binding  nucleus  nucleoplasm  zinc ion binding  protein ubiquitination  protein ubiquitination  transferase activity  regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  negative regulation of transcription, DNA-templated  co-SMAD binding  R-SMAD binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  DNA binding  protein binding  nucleus  nucleoplasm  zinc ion binding  protein ubiquitination  protein ubiquitination  transferase activity  regulation of transforming growth factor beta receptor signaling pathway  negative regulation of BMP signaling pathway  negative regulation of transcription, DNA-templated  co-SMAD binding  R-SMAD binding  
NDEx NetworkTRIM33
Atlas of Cancer Signalling NetworkTRIM33
Wikipedia pathwaysTRIM33
Orthology - Evolution
OrthoDB51592
GeneTree (enSembl)ENSG00000197323
Phylogenetic Trees/Animal Genes : TreeFamTRIM33
Homologs : HomoloGeneTRIM33
Homology/Alignments : Family Browser (UCSC)TRIM33
Gene fusions - Rearrangements
Fusion : MitelmanPOSTN/TRIM33 [13q13.3/1p13.2]  
Fusion : MitelmanTRIM33/COL24A1 [1p13.2/1p22.3]  
Fusion : MitelmanTRIM33/RET [1p13.2/10q11.21]  
Fusion : QuiverTRIM33
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM33 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM33
dbVarTRIM33
ClinVarTRIM33
MonarchTRIM33
1000_GenomesTRIM33 
Exome Variant ServerTRIM33
GNOMAD BrowserENSG00000197323
Varsome BrowserTRIM33
ACMGTRIM33 variants
VarityQ9UPN9
Genomic Variants (DGV)TRIM33 [DGVbeta]
DECIPHERTRIM33 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIM33 
Mutations
ICGC Data PortalTRIM33 
TCGA Data PortalTRIM33 
Broad Tumor PortalTRIM33
OASIS PortalTRIM33 [ Somatic mutations - Copy number]
Cancer Gene: CensusTRIM33 
Somatic Mutations in Cancer : COSMICTRIM33  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRIM33
Mutations and Diseases : HGMDTRIM33
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRIM33
DgiDB (Drug Gene Interaction Database)TRIM33
DoCM (Curated mutations)TRIM33
CIViC (Clinical Interpretations of Variants in Cancer)TRIM33
Cancer3DTRIM33
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605769   
Orphanet905   
DisGeNETTRIM33
MedgenTRIM33
Genetic Testing Registry TRIM33
NextProtQ9UPN9 [Medical]
GENETestsTRIM33
Target ValidationTRIM33
Huge Navigator TRIM33 [HugePedia]
ClinGenTRIM33
Clinical trials, drugs, therapy
MyCancerGenomeTRIM33
Protein Interactions : CTDTRIM33
Pharm GKB GenePA38118
PharosQ9UPN9
Clinical trialTRIM33
Miscellaneous
canSAR (ICR)TRIM33
HarmonizomeTRIM33
DataMed IndexTRIM33
Probes
Litterature
PubMed105 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRIM33
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:21 CEST 2021

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