TRIM33 (tripartite motif containing 33)

2003-02-01  

Identity

HGNC
LOCATION
1p13.2
LOCUSID
ALIAS
ECTO,PTC7,RFG7,TF1G,TIF1G,TIF1GAMMA,TIFGAMMA
FUSION GENES

Other Information

Locus ID:

NCBI: 51592
MIM: 605769
HGNC: 16290
Ensembl: ENSG00000197323

Variants:

dbSNP: 51592
ClinVar: 51592
TCGA: ENSG00000197323
COSMIC: TRIM33

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197323ENST00000358465Q9UPN9
ENSG00000197323ENST00000369543Q9UPN9
ENSG00000197323ENST00000448034H0Y612

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
Downregulation of SMAD2/3:SMAD4 transcriptional activityREACTOMER-HSA-2173795
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167511022006Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.154
221967282011A poised chromatin platform for TGF-β access to master regulators.118
206030192010TIF1gamma controls erythroid cell fate by regulating transcription elongation.93
217268122011Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities.65
240378942013Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1γ.64
196291682009Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.52
302619002018Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-β-induced epithelial-mesenchymal transition and metastasis by controlling TIF1γ in non-small cell lung cancer.45
256394862015Tumour suppressor TRIM33 targets nuclear β-catenin degradation.37
120969142002Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression.36
215370842011Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia.36

Citation

Dessen P

TRIM33 (tripartite motif containing 33)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/502/trim33