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TRIM38 (tripartite motif containing 38)

Identity

Alias_namesRNF15
ring finger protein 15
tripartite motif-containing 38
Alias_symbol (synonym)RORET
Other alias
HGNC (Hugo) TRIM38
LocusID (NCBI) 10475
Atlas_Id 54723
Location 6p22.2  [Link to chromosome band 6p22]
Location_base_pair Starts at 25962689 and ends at 25987329 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BEND6 (6p12.1) / TRIM38 (6p22.2)DST (6p12.1) / TRIM38 (6p22.2)TRIM38 (6p22.2) / KIAA0232 (4p16.1)
DST 6p12.1 / TRIM38 6p22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(6;6)(p12;p22) DST/TRIM38
t(6;6)(p12;p22) BEND6/TRIM38


External links

Nomenclature
HGNC (Hugo)TRIM38   10059
Cards
Entrez_Gene (NCBI)TRIM38  10475  tripartite motif containing 38
AliasesRNF15; RORET
GeneCards (Weizmann)TRIM38
Ensembl hg19 (Hinxton)ENSG00000112343 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112343 [Gene_View]  ENSG00000112343 [Sequence]  chr6:25962689-25987329 [Contig_View]  TRIM38 [Vega]
ICGC DataPortalENSG00000112343
TCGA cBioPortalTRIM38
AceView (NCBI)TRIM38
Genatlas (Paris)TRIM38
WikiGenes10475
SOURCE (Princeton)TRIM38
Genetics Home Reference (NIH)TRIM38
Genomic and cartography
GoldenPath hg38 (UCSC)TRIM38  -     chr6:25962689-25987329 +  6p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIM38  -     6p22.2   [Description]    (hg19-Feb_2009)
EnsemblTRIM38 - 6p22.2 [CytoView hg19]  TRIM38 - 6p22.2 [CytoView hg38]
Mapping of homologs : NCBITRIM38 [Mapview hg19]  TRIM38 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB209906 AK310777 AK313248 BC026930 BX640949
RefSeq transcript (Entrez)NM_006355
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRIM38
Cluster EST : UnigeneHs.742026 [ NCBI ]
CGAP (NCI)Hs.742026
Alternative Splicing GalleryENSG00000112343
Gene ExpressionTRIM38 [ NCBI-GEO ]   TRIM38 [ EBI - ARRAY_EXPRESS ]   TRIM38 [ SEEK ]   TRIM38 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM38 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10475
GTEX Portal (Tissue expression)TRIM38
Human Protein AtlasENSG00000112343-TRIM38 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00635   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00635  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00635
Splice isoforms : SwissVarO00635
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusO00635
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    ZF_BBOX (PS50119)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)B30.2/SPRY    Butyrophylin_SPRY    ConA-like_dom_sf    PRY    SPRY/PRY_TRIM38    SPRY_dom    Znf_B-box    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)PRY (PF13765)    SPRY (PF00622)    zf-B_box (PF00643)   
Domain families : Pfam (NCBI)pfam13765    pfam00622    pfam00643   
Domain families : Smart (EMBL)BBOX (SM00336)  PRY (SM00589)  RING (SM00184)  SPRY (SM00449)  
Conserved Domain (NCBI)TRIM38
DMDM Disease mutations10475
Blocks (Seattle)TRIM38
SuperfamilyO00635
Human Protein Atlas [tissue]ENSG00000112343-TRIM38 [tissue]
Peptide AtlasO00635
HPRD15555
IPIIPI00007365   
Protein Interaction databases
DIP (DOE-UCLA)O00635
IntAct (EBI)O00635
FunCoupENSG00000112343
BioGRIDTRIM38
STRING (EMBL)TRIM38
ZODIACTRIM38
Ontologies - Pathways
QuickGOO00635
Ontology : AmiGOprotein binding  cellular_component  cytosol  zinc ion binding  transferase activity  regulation of interferon-beta production  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  proteasome-mediated ubiquitin-dependent protein catabolic process  positive regulation of viral genome replication  positive regulation of viral entry into host cell  negative regulation of defense response to virus  positive regulation of DNA-binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  interferon-gamma-mediated signaling pathway  protein K48-linked ubiquitination  
Ontology : EGO-EBIprotein binding  cellular_component  cytosol  zinc ion binding  transferase activity  regulation of interferon-beta production  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  proteasome-mediated ubiquitin-dependent protein catabolic process  positive regulation of viral genome replication  positive regulation of viral entry into host cell  negative regulation of defense response to virus  positive regulation of DNA-binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  interferon-gamma-mediated signaling pathway  protein K48-linked ubiquitination  
NDEx NetworkTRIM38
Atlas of Cancer Signalling NetworkTRIM38
Wikipedia pathwaysTRIM38
Orthology - Evolution
OrthoDB10475
GeneTree (enSembl)ENSG00000112343
Phylogenetic Trees/Animal Genes : TreeFamTRIM38
HOVERGENO00635
HOGENOMO00635
Homologs : HomoloGeneTRIM38
Homology/Alignments : Family Browser (UCSC)TRIM38
Gene fusions - Rearrangements
Fusion : MitelmanBEND6/TRIM38 [6p12.1/6p22.2]  [t(6;6)(p12;p22)]  
Fusion : MitelmanDST/TRIM38 [6p12.1/6p22.2]  [t(6;6)(p12;p22)]  
Fusion PortalDST 6p12.1 TRIM38 6p22.2 LUSC
Fusion : QuiverTRIM38
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM38 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM38
dbVarTRIM38
ClinVarTRIM38
1000_GenomesTRIM38 
Exome Variant ServerTRIM38
ExAC (Exome Aggregation Consortium)ENSG00000112343
GNOMAD BrowserENSG00000112343
Varsome BrowserTRIM38
Genetic variants : HAPMAP10475
Genomic Variants (DGV)TRIM38 [DGVbeta]
DECIPHERTRIM38 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIM38 
Mutations
ICGC Data PortalTRIM38 
TCGA Data PortalTRIM38 
Broad Tumor PortalTRIM38
OASIS PortalTRIM38 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM38  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRIM38
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIM38
DgiDB (Drug Gene Interaction Database)TRIM38
DoCM (Curated mutations)TRIM38 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIM38 (select a term)
intoGenTRIM38
Cancer3DTRIM38(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTRIM38
MedgenTRIM38
Genetic Testing Registry TRIM38
NextProtO00635 [Medical]
TSGene10475
GENETestsTRIM38
Target ValidationTRIM38
Huge Navigator TRIM38 [HugePedia]
snp3D : Map Gene to Disease10475
BioCentury BCIQTRIM38
ClinGenTRIM38
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10475
Chemical/Pharm GKB GenePA35532
Clinical trialTRIM38
Miscellaneous
canSAR (ICR)TRIM38 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIM38
EVEXTRIM38
GoPubMedTRIM38
iHOPTRIM38
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:46:50 CET 2018

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