TRIM56 (tripartite motif containing 56)

2018-02-01  

Identity

HGNC
TRIM56
LOCATION
7q22.1
LOCUSID
81844
ALIAS
RNF109
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81844
MIM: 616996
HGNC: 19028
Ensembl: ENSG00000169871

Variants:

dbSNP: 81844
ClinVar: 81844
TCGA: ENSG00000169871
COSMIC: TRIM56

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169871ENST00000306085Q9BRZ2
ENSG00000169871ENST00000412507C9JI91
ENSG00000169871ENST00000467847A0A0D9SF19

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
Regulation of innate immune responses to cytosolic DNAREACTOMER-HSA-3134975

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
210744592010The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA.156
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
212891182011TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection.43
294269042018TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing.35
252533382014Overlapping and distinct molecular determinants dictating the antiviral activities of TRIM56 against flaviviruses and coronavirus.29
229481602012TRIM56 is an essential component of the TLR3 antiviral signaling pathway.27
268890272016The C-Terminal Tail of TRIM56 Dictates Antiviral Restriction of Influenza A and B Viruses by Impeding Viral RNA Synthesis.21
280843202017Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.9
287717212018The ubiquitin ligase TRIM56 inhibits ovarian cancer progression by targeting vimentin.9
292147752018TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling.3

Citation

Dessen P

TRIM56 (tripartite motif containing 56)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57264/trim56