Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TRIM6 (tripartite motif containing 6)

Identity

Alias (NCBI)RNF89
HGNC (Hugo) TRIM6
HGNC Alias symbRNF89
HGNC Previous nametripartite motif-containing 6
LocusID (NCBI) 117854
Atlas_Id 75172
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 5596111 and ends at 5612952 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRIM6 (11p15.4) / TRIM34 (11p15.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)TRIM6   16277
Cards
Entrez_Gene (NCBI)TRIM6    tripartite motif containing 6
AliasesRNF89
GeneCards (Weizmann)TRIM6
Ensembl hg19 (Hinxton)ENSG00000121236 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121236 [Gene_View]  ENSG00000121236 [Sequence]  chr11:5596111-5612952 [Contig_View]  TRIM6 [Vega]
ICGC DataPortalENSG00000121236
TCGA cBioPortalTRIM6
AceView (NCBI)TRIM6
Genatlas (Paris)TRIM6
SOURCE (Princeton)TRIM6
Genetics Home Reference (NIH)TRIM6
Genomic and cartography
GoldenPath hg38 (UCSC)TRIM6  -     chr11:5596111-5612952 +  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIM6  -     11p15.4   [Description]    (hg19-Feb_2009)
GoldenPathTRIM6 - 11p15.4 [CytoView hg19]  TRIM6 - 11p15.4 [CytoView hg38]
ImmunoBaseENSG00000121236
Genome Data Viewer NCBITRIM6 [Mapview hg19]  
OMIM607564   
Gene and transcription
Genbank (Entrez)AF220030 AK023210 AK027664 AK290172 AK293295
RefSeq transcript (Entrez)NM_001003818 NM_001198644 NM_001198645 NM_058166
Consensus coding sequences : CCDS (NCBI)TRIM6
Gene ExpressionTRIM6 [ NCBI-GEO ]   TRIM6 [ EBI - ARRAY_EXPRESS ]   TRIM6 [ SEEK ]   TRIM6 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM6 [ Firebrowse - Broad ]
GenevisibleExpression of TRIM6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)117854
GTEX Portal (Tissue expression)TRIM6
Human Protein AtlasENSG00000121236-TRIM6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C030   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C030  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C030
PhosPhoSitePlusQ9C030
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    ZF_BBOX (PS50119)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)B30.2/SPRY    B30.2/SPRY_sf    Butyrophylin_SPRY    ConA-like_dom_sf    PRY    PRY/SPRY_TRIM6    SPRY_dom    Znf-RING_LisH    Znf_B-box    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)SPRY (PF00622)    zf-B_box (PF00643)    zf-RING_UBOX (PF13445)   
Domain families : Pfam (NCBI)pfam00622    pfam00643    pfam13445   
Domain families : Smart (EMBL)BBOX (SM00336)  PRY (SM00589)  RING (SM00184)  SPRY (SM00449)  
Conserved Domain (NCBI)TRIM6
SuperfamilyQ9C030
AlphaFold pdb e-kbQ9C030   
Human Protein Atlas [tissue]ENSG00000121236-TRIM6 [tissue]
HPRD12123
Protein Interaction databases
DIP (DOE-UCLA)Q9C030
IntAct (EBI)Q9C030
BioGRIDTRIM6
STRING (EMBL)TRIM6
ZODIACTRIM6
Ontologies - Pathways
QuickGOQ9C030
Ontology : AmiGOprotein polyubiquitination  positive regulation of defense response to virus by host  positive regulation of cytokine production involved in immune response  protein binding  nucleoplasm  cytoplasm  cytoplasm  cytosol  zinc ion binding  regulation of gene expression  positive regulation of autophagy  negative regulation of gene expression  positive regulation of peptidyl-threonine phosphorylation  free ubiquitin chain polymerization  protein ubiquitination  protein kinase binding  protein kinase binding  protein-macromolecule adaptor activity  response to lipopolysaccharide  regulation of protein localization  positive regulation of peptidyl-serine phosphorylation  cellular response to interferon-beta  identical protein binding  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of viral genome replication  innate immune response  negative regulation of transcription, DNA-templated  regulation of viral entry into host cell  positive regulation of NF-kappaB transcription factor activity  positive regulation of type I interferon-mediated signaling pathway  ubiquitin protein ligase activity  ubiquitin protein ligase activity  cellular response to virus  regulation of NIK/NF-kappaB signaling  protein tyrosine kinase binding  positive regulation of transcription regulatory region DNA binding  negative regulation of stem cell differentiation  
Ontology : EGO-EBIprotein polyubiquitination  positive regulation of defense response to virus by host  positive regulation of cytokine production involved in immune response  protein binding  nucleoplasm  cytoplasm  cytoplasm  cytosol  zinc ion binding  regulation of gene expression  positive regulation of autophagy  negative regulation of gene expression  positive regulation of peptidyl-threonine phosphorylation  free ubiquitin chain polymerization  protein ubiquitination  protein kinase binding  protein kinase binding  protein-macromolecule adaptor activity  response to lipopolysaccharide  regulation of protein localization  positive regulation of peptidyl-serine phosphorylation  cellular response to interferon-beta  identical protein binding  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of viral genome replication  innate immune response  negative regulation of transcription, DNA-templated  regulation of viral entry into host cell  positive regulation of NF-kappaB transcription factor activity  positive regulation of type I interferon-mediated signaling pathway  ubiquitin protein ligase activity  ubiquitin protein ligase activity  cellular response to virus  regulation of NIK/NF-kappaB signaling  protein tyrosine kinase binding  positive regulation of transcription regulatory region DNA binding  negative regulation of stem cell differentiation  
NDEx NetworkTRIM6
Atlas of Cancer Signalling NetworkTRIM6
Wikipedia pathwaysTRIM6
Orthology - Evolution
OrthoDB117854
GeneTree (enSembl)ENSG00000121236
Phylogenetic Trees/Animal Genes : TreeFamTRIM6
Homologs : HomoloGeneTRIM6
Homology/Alignments : Family Browser (UCSC)TRIM6
Gene fusions - Rearrangements
Fusion : QuiverTRIM6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM6
dbVarTRIM6
ClinVarTRIM6
MonarchTRIM6
1000_GenomesTRIM6 
Exome Variant ServerTRIM6
GNOMAD BrowserENSG00000121236
Varsome BrowserTRIM6
ACMGTRIM6 variants
VarityQ9C030
Genomic Variants (DGV)TRIM6 [DGVbeta]
DECIPHERTRIM6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIM6 
Mutations
ICGC Data PortalTRIM6 
TCGA Data PortalTRIM6 
Broad Tumor PortalTRIM6
OASIS PortalTRIM6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRIM6
Mutations and Diseases : HGMDTRIM6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRIM6
DgiDB (Drug Gene Interaction Database)TRIM6
DoCM (Curated mutations)TRIM6
CIViC (Clinical Interpretations of Variants in Cancer)TRIM6
Cancer3DTRIM6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607564   
Orphanet
DisGeNETTRIM6
MedgenTRIM6
Genetic Testing Registry TRIM6
NextProtQ9C030 [Medical]
GENETestsTRIM6
Target ValidationTRIM6
Huge Navigator TRIM6 [HugePedia]
ClinGenTRIM6
Clinical trials, drugs, therapy
MyCancerGenomeTRIM6
Protein Interactions : CTDTRIM6
Pharm GKB GenePA38110
PharosQ9C030
Clinical trialTRIM6
Miscellaneous
canSAR (ICR)TRIM6
HarmonizomeTRIM6
DataMed IndexTRIM6
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRIM6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:26:57 CEST 2021
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