TRIM62 (tripartite motif containing 62)

2009-09-01 Affiliation

Identity

HGNC

TRIM62

LOCATION

1p35.1

LOCUSID

55223

ALIAS

DEAR1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55223
MIM: 616755
HGNC: 25574
Ensembl: ENSG00000116525

Variants:

dbSNP: 55223
ClinVar: 55223
TCGA: ENSG00000116525
COSMIC: TRIM62

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000116525	ENST00000291416	Q9BVG3
ENSG00000116525	ENST00000543586	Q9BVG3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon gamma signaling	REACTOME	R-HSA-877300

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
26488816	2015	Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.	23
19536326	2009	DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer.	21
25248926	2015	Loss of TRIM62 expression is an independent adverse prognostic factor in acute myeloid leukemia.	13
23838884	2013	DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-β-driven epithelial-mesenchymal transition.	12
23402750	2013	Characterization of TRIM62 as a RING finger E3 ubiquitin ligase and its subcellular localization.	8
27793172	2016	Tripartite motif containing 62 is a novel prognostic marker and suppresses tumor metastasis via c-Jun/Slug signaling-mediated epithelial-mesenchymal transition in cervical cancer.	7
25261235	2014	DEAR1, a novel tumor suppressor that regulates cell polarity and epithelial plasticity.	6
19536324	2009	A new tumor suppressor that regulates tissue architecture.	3

Citation

Dessen P

TRIM62 (tripartite motif containing 62)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51075/trim62