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TRIM63 (tripartite motif containing 63)

Identity

Alias (NCBI)IRF
MURF1
MURF2
RNF28
SMRZ
HGNC (Hugo) TRIM63
HGNC Alias symbMURF-1
IRF
SMRZ
HGNC Alias namemuscle-specific RING finger protein 1
 iris ring finger protein
 striated muscle RING zinc finger protein
HGNC Previous nameRNF28
HGNC Previous namering finger protein 28
 tripartite motif containing 63, E3 ubiquitin protein ligase
LocusID (NCBI) 84676
Atlas_Id 42134
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 26051305 and ends at 26067634 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SIRT2 (19q13.2) / TRIM63 (1p36.11)TRIM63 (1p36.11) / DTWD2 (5q23.1)TRIM63 (1p36.11) / PTMA (2q37.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TRIM63   16007
LRG (Locus Reference Genomic)LRG_757
Cards
Entrez_Gene (NCBI)TRIM63    tripartite motif containing 63
AliasesIRF; MURF1; MURF2; RNF28; 
SMRZ
GeneCards (Weizmann)TRIM63
Ensembl hg19 (Hinxton)ENSG00000158022 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158022 [Gene_View]  ENSG00000158022 [Sequence]  chr1:26051305-26067634 [Contig_View]  TRIM63 [Vega]
ICGC DataPortalENSG00000158022
TCGA cBioPortalTRIM63
AceView (NCBI)TRIM63
Genatlas (Paris)TRIM63
SOURCE (Princeton)TRIM63
Genetics Home Reference (NIH)TRIM63
Genomic and cartography
GoldenPath hg38 (UCSC)TRIM63  -     chr1:26051305-26067634 -  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIM63  -     1p36.11   [Description]    (hg19-Feb_2009)
GoldenPathTRIM63 - 1p36.11 [CytoView hg19]  TRIM63 - 1p36.11 [CytoView hg38]
ImmunoBaseENSG00000158022
Genome Data Viewer NCBITRIM63 [Mapview hg19]  
OMIM606131   
Gene and transcription
Genbank (Entrez)AF353673 AF361946 AI351421 AJ276484 AK056942
RefSeq transcript (Entrez)NM_032588
Consensus coding sequences : CCDS (NCBI)TRIM63
Gene ExpressionTRIM63 [ NCBI-GEO ]   TRIM63 [ EBI - ARRAY_EXPRESS ]   TRIM63 [ SEEK ]   TRIM63 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM63 [ Firebrowse - Broad ]
GenevisibleExpression of TRIM63 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84676
GTEX Portal (Tissue expression)TRIM63
Human Protein AtlasENSG00000158022-TRIM63 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ969Q1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ969Q1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ969Q1
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ969Q1
Domaine pattern : Prosite (Expaxy)COS (PS51262)    ZF_BBOX (PS50119)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)COS_domain    TRIM63_RING-HC    Znf-RING_LisH    Znf_B-box    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)zf-B_box (PF00643)    zf-RING_UBOX (PF13445)   
Domain families : Pfam (NCBI)pfam00643    pfam13445   
Domain families : Smart (EMBL)BBOX (SM00336)  RING (SM00184)  
Conserved Domain (NCBI)TRIM63
PDB (RSDB)2D8U    3DDT    4M3L   
PDB Europe2D8U    3DDT    4M3L   
PDB (PDBSum)2D8U    3DDT    4M3L   
PDB (IMB)2D8U    3DDT    4M3L   
Structural Biology KnowledgeBase2D8U    3DDT    4M3L   
SCOP (Structural Classification of Proteins)2D8U    3DDT    4M3L   
CATH (Classification of proteins structures)2D8U    3DDT    4M3L   
SuperfamilyQ969Q1
AlphaFold pdb e-kbQ969Q1   
Human Protein Atlas [tissue]ENSG00000158022-TRIM63 [tissue]
HPRD05843
Protein Interaction databases
DIP (DOE-UCLA)Q969Q1
IntAct (EBI)Q969Q1
BioGRIDTRIM63
STRING (EMBL)TRIM63
ZODIACTRIM63
Ontologies - Pathways
QuickGOQ969Q1
Ontology : AmiGOprotein binding  nucleus  cytoplasm  cytoplasm  cytoplasm  microtubule  muscle contraction  signal transduction  zinc ion binding  negative regulation of cardiac muscle hypertrophy  skeletal muscle atrophy  response to electrical stimulus involved in regulation of muscle adaptation  protein ubiquitination  protein ubiquitination  Z disc  M band  titin binding  response to glucocorticoid  ubiquitin protein ligase activity  response to interleukin-1  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  cytoplasm  cytoplasm  microtubule  muscle contraction  signal transduction  zinc ion binding  negative regulation of cardiac muscle hypertrophy  skeletal muscle atrophy  response to electrical stimulus involved in regulation of muscle adaptation  protein ubiquitination  protein ubiquitination  Z disc  M band  titin binding  response to glucocorticoid  ubiquitin protein ligase activity  response to interleukin-1  
NDEx NetworkTRIM63
Atlas of Cancer Signalling NetworkTRIM63
Wikipedia pathwaysTRIM63
Orthology - Evolution
OrthoDB84676
GeneTree (enSembl)ENSG00000158022
Phylogenetic Trees/Animal Genes : TreeFamTRIM63
Homologs : HomoloGeneTRIM63
Homology/Alignments : Family Browser (UCSC)TRIM63
Gene fusions - Rearrangements
Fusion : QuiverTRIM63
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM63 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM63
dbVarTRIM63
ClinVarTRIM63
MonarchTRIM63
1000_GenomesTRIM63 
Exome Variant ServerTRIM63
GNOMAD BrowserENSG00000158022
Varsome BrowserTRIM63
ACMGTRIM63 variants
VarityQ969Q1
Genomic Variants (DGV)TRIM63 [DGVbeta]
DECIPHERTRIM63 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIM63 
Mutations
ICGC Data PortalTRIM63 
TCGA Data PortalTRIM63 
Broad Tumor PortalTRIM63
OASIS PortalTRIM63 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM63  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRIM63
Mutations and Diseases : HGMDTRIM63
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRIM63
DgiDB (Drug Gene Interaction Database)TRIM63
DoCM (Curated mutations)TRIM63
CIViC (Clinical Interpretations of Variants in Cancer)TRIM63
Cancer3DTRIM63
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606131   
Orphanet
DisGeNETTRIM63
MedgenTRIM63
Genetic Testing Registry TRIM63
NextProtQ969Q1 [Medical]
GENETestsTRIM63
Target ValidationTRIM63
Huge Navigator TRIM63 [HugePedia]
ClinGenTRIM63
Clinical trials, drugs, therapy
MyCancerGenomeTRIM63
Protein Interactions : CTDTRIM63
Pharm GKB GenePA34431
PharosQ969Q1
Clinical trialTRIM63
Miscellaneous
canSAR (ICR)TRIM63
HarmonizomeTRIM63
DataMed IndexTRIM63
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRIM63
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:24 CEST 2021

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