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TRIM63 (tripartite motif containing 63)

Identity

Alias_namesRNF28
ring finger protein 28
tripartite motif containing 63, E3 ubiquitin protein ligase
Alias_symbol (synonym)MURF-1
IRF
SMRZ
Other aliasMURF1
MURF2
HGNC (Hugo) TRIM63
LocusID (NCBI) 84676
Atlas_Id 42134
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 26377796 and ends at 26394125 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SIRT2 (19q13.2) / TRIM63 (1p36.11)TRIM63 (1p36.11) / DTWD2 (5q23.1)TRIM63 (1p36.11) / PTMA (2q37.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRIM63   16007
LRG (Locus Reference Genomic)LRG_757
Cards
Entrez_Gene (NCBI)TRIM63  84676  tripartite motif containing 63
AliasesIRF; MURF1; MURF2; RNF28; 
SMRZ
GeneCards (Weizmann)TRIM63
Ensembl hg19 (Hinxton)ENSG00000158022 [Gene_View]  chr1:26377796-26394125 [Contig_View]  TRIM63 [Vega]
Ensembl hg38 (Hinxton)ENSG00000158022 [Gene_View]  chr1:26377796-26394125 [Contig_View]  TRIM63 [Vega]
ICGC DataPortalENSG00000158022
TCGA cBioPortalTRIM63
AceView (NCBI)TRIM63
Genatlas (Paris)TRIM63
WikiGenes84676
SOURCE (Princeton)TRIM63
Genetics Home Reference (NIH)TRIM63
Genomic and cartography
GoldenPath hg19 (UCSC)TRIM63  -     chr1:26377796-26394125 -  1p36.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TRIM63  -     1p36.11   [Description]    (hg38-Dec_2013)
EnsemblTRIM63 - 1p36.11 [CytoView hg19]  TRIM63 - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBITRIM63 [Mapview hg19]  TRIM63 [Mapview hg38]
OMIM606131   
Gene and transcription
Genbank (Entrez)AF353673 AF361946 AI351421 AJ276484 AK056942
RefSeq transcript (Entrez)NM_032588
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_033268 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)TRIM63
Cluster EST : UnigeneHs.279709 [ NCBI ]
CGAP (NCI)Hs.279709
Alternative Splicing GalleryENSG00000158022
Gene ExpressionTRIM63 [ NCBI-GEO ]   TRIM63 [ EBI - ARRAY_EXPRESS ]   TRIM63 [ SEEK ]   TRIM63 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM63 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84676
GTEX Portal (Tissue expression)TRIM63
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ969Q1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ969Q1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ969Q1
Splice isoforms : SwissVarQ969Q1
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ969Q1
Domaine pattern : Prosite (Expaxy)COS (PS51262)    ZF_BBOX (PS50119)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)COS_domain    Znf-RING_LisH    Znf_B-box    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)zf-B_box (PF00643)    zf-RING_UBOX (PF13445)   
Domain families : Pfam (NCBI)pfam00643    pfam13445   
Domain families : Smart (EMBL)BBOX (SM00336)  RING (SM00184)  
Conserved Domain (NCBI)TRIM63
DMDM Disease mutations84676
Blocks (Seattle)TRIM63
PDB (SRS)2D8U    3DDT    4M3L   
PDB (PDBSum)2D8U    3DDT    4M3L   
PDB (IMB)2D8U    3DDT    4M3L   
PDB (RSDB)2D8U    3DDT    4M3L   
Structural Biology KnowledgeBase2D8U    3DDT    4M3L   
SCOP (Structural Classification of Proteins)2D8U    3DDT    4M3L   
CATH (Classification of proteins structures)2D8U    3DDT    4M3L   
SuperfamilyQ969Q1
Human Protein AtlasENSG00000158022
Peptide AtlasQ969Q1
HPRD05843
IPIIPI00000309   IPI00847788   
Protein Interaction databases
DIP (DOE-UCLA)Q969Q1
IntAct (EBI)Q969Q1
FunCoupENSG00000158022
BioGRIDTRIM63
STRING (EMBL)TRIM63
ZODIACTRIM63
Ontologies - Pathways
QuickGOQ969Q1
Ontology : AmiGOubiquitin-protein transferase activity  signal transducer activity  protein binding  nucleus  cytoplasm  cytoplasm  microtubule  muscle contraction  signal transduction  zinc ion binding  skeletal muscle atrophy  response to electrical stimulus involved in regulation of muscle adaptation  protein ubiquitination  ligase activity  Z disc  M band  titin binding  response to glucocorticoid  response to interleukin-1  
Ontology : EGO-EBIubiquitin-protein transferase activity  signal transducer activity  protein binding  nucleus  cytoplasm  cytoplasm  microtubule  muscle contraction  signal transduction  zinc ion binding  skeletal muscle atrophy  response to electrical stimulus involved in regulation of muscle adaptation  protein ubiquitination  ligase activity  Z disc  M band  titin binding  response to glucocorticoid  response to interleukin-1  
NDEx NetworkTRIM63
Atlas of Cancer Signalling NetworkTRIM63
Wikipedia pathwaysTRIM63
Orthology - Evolution
OrthoDB84676
GeneTree (enSembl)ENSG00000158022
Phylogenetic Trees/Animal Genes : TreeFamTRIM63
HOVERGENQ969Q1
HOGENOMQ969Q1
Homologs : HomoloGeneTRIM63
Homology/Alignments : Family Browser (UCSC)TRIM63
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM63 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM63
dbVarTRIM63
ClinVarTRIM63
1000_GenomesTRIM63 
Exome Variant ServerTRIM63
ExAC (Exome Aggregation Consortium)TRIM63 (select the gene name)
Genetic variants : HAPMAP84676
Genomic Variants (DGV)TRIM63 [DGVbeta]
DECIPHER (Syndromes)1:26377796-26394125  ENSG00000158022
CONAN: Copy Number AnalysisTRIM63 
Mutations
ICGC Data PortalTRIM63 
TCGA Data PortalTRIM63 
Broad Tumor PortalTRIM63
OASIS PortalTRIM63 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM63  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRIM63
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIM63
DgiDB (Drug Gene Interaction Database)TRIM63
DoCM (Curated mutations)TRIM63 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIM63 (select a term)
intoGenTRIM63
Cancer3DTRIM63(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606131   
Orphanet
MedgenTRIM63
Genetic Testing Registry TRIM63
NextProtQ969Q1 [Medical]
TSGene84676
GENETestsTRIM63
Huge Navigator TRIM63 [HugePedia]
snp3D : Map Gene to Disease84676
BioCentury BCIQTRIM63
ClinGenTRIM63
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84676
Chemical/Pharm GKB GenePA34431
Clinical trialTRIM63
Miscellaneous
canSAR (ICR)TRIM63 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIM63
EVEXTRIM63
GoPubMedTRIM63
iHOPTRIM63
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:23:30 CEST 2017

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