TRIM65 (tripartite motif containing 65)

2016-10-01  

Identity

HGNC
TRIM65
LOCATION
17q25.1
LOCUSID
201292
ALIAS
4732463G12Rik
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 201292
HGNC: 27316
Ensembl: ENSG00000141569

Variants:

dbSNP: 201292
ClinVar: 201292
TCGA: ENSG00000141569
COSMIC: TRIM65

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141569ENST00000269383Q6PJ69
ENSG00000141569ENST00000540128H0YGS7
ENSG00000141569ENST00000543309H0YG27
ENSG00000141569ENST00000591668K7EJ59
ENSG00000141569ENST00000592642K7EM44

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
247782522014TRIM65 regulates microRNA activity by ubiquitination of TNRC6.25
300752042018TRIM65 supports bladder urothelial carcinoma cell aggressiveness by promoting ANXA2 ubiquitination and degradation.12
280843202017Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.9
285944022017ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65.7
287546882017TRIM65 triggers β-catenin signaling via ubiquitylation of Axin1 to promote hepatocellular carcinoma.7
278292292016Knockdown of TRIM65 inhibits lung cancer cell proliferation, migration and invasion: A therapeutic target in human lung cancer.6
270122012016TRIM65 negatively regulates p53 through ubiquitination.4
275838432016Analysis of genetic polymorphisms associated with leukoaraiosis in the southern Chinese population: A case-control study.3
313322862019Ubiquitin ligase TRIM65 promotes colorectal cancer metastasis by targeting ARHGAP35 for protein degradation.3
310499602019LncRNA LINC01857 promotes growth, migration, and invasion of glioma by modulating miR-1281/TRIM65 axis.2

Citation

Dessen P

TRIM65 (tripartite motif containing 65)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56357/trim65