Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TRIM68 (tripartite motif containing 68)

Identity

Alias (NCBI)GC109
RNF137
SS-56
SS56
HGNC (Hugo) TRIM68
HGNC Alias symbSS-56
FLJ10369
HGNC Previous nameRNF137
HGNC Previous namering finger protein 137
 tripartite motif-containing 68
LocusID (NCBI) 55128
Atlas_Id 42129
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 4598672 and ends at 4608231 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRIM68 (11p15.4) / TRIM68 (11p15.4)YEATS2 (3q27.1) / TRIM68 (11p15.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TRIM68   21161
Cards
Entrez_Gene (NCBI)TRIM68    tripartite motif containing 68
AliasesGC109; RNF137; SS-56; SS56
GeneCards (Weizmann)TRIM68
Ensembl hg19 (Hinxton)ENSG00000167333 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167333 [Gene_View]  ENSG00000167333 [Sequence]  chr11:4598672-4608231 [Contig_View]  TRIM68 [Vega]
ICGC DataPortalENSG00000167333
TCGA cBioPortalTRIM68
AceView (NCBI)TRIM68
Genatlas (Paris)TRIM68
SOURCE (Princeton)TRIM68
Genetics Home Reference (NIH)TRIM68
Genomic and cartography
GoldenPath hg38 (UCSC)TRIM68  -     chr11:4598672-4608231 -  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIM68  -     11p15.4   [Description]    (hg19-Feb_2009)
GoldenPathTRIM68 - 11p15.4 [CytoView hg19]  TRIM68 - 11p15.4 [CytoView hg38]
ImmunoBaseENSG00000167333
genome Data Viewer NCBITRIM68 [Mapview hg19]  
OMIM613184   
Gene and transcription
Genbank (Entrez)AF360739 AF439153 AK001231 AK022923 AK056523
RefSeq transcript (Entrez)NM_001304496 NM_018073
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRIM68
Alternative Splicing GalleryENSG00000167333
Gene ExpressionTRIM68 [ NCBI-GEO ]   TRIM68 [ EBI - ARRAY_EXPRESS ]   TRIM68 [ SEEK ]   TRIM68 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM68 [ Firebrowse - Broad ]
GenevisibleExpression of TRIM68 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55128
GTEX Portal (Tissue expression)TRIM68
Human Protein AtlasENSG00000167333-TRIM68 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6AZZ1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6AZZ1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6AZZ1
Splice isoforms : SwissVarQ6AZZ1
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ6AZZ1
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    ZF_BBOX (PS50119)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)B30.2/SPRY    Butyrophylin_SPRY    ConA-like_dom_sf    PRY    SPRY_dom    TRIM68_RING-HC    Znf_B-box    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)PRY (PF13765)    SPRY (PF00622)    zf-B_box (PF00643)   
Domain families : Pfam (NCBI)pfam13765    pfam00622    pfam00643   
Domain families : Smart (EMBL)BBOX (SM00336)  PRY (SM00589)  RING (SM00184)  SPRY (SM00449)  
Conserved Domain (NCBI)TRIM68
Blocks (Seattle)TRIM68
SuperfamilyQ6AZZ1
Human Protein Atlas [tissue]ENSG00000167333-TRIM68 [tissue]
Peptide AtlasQ6AZZ1
HPRD11507
IPIIPI00292487   IPI01011103   IPI00977425   IPI00976835   IPI00983538   
Protein Interaction databases
DIP (DOE-UCLA)Q6AZZ1
IntAct (EBI)Q6AZZ1
BioGRIDTRIM68
STRING (EMBL)TRIM68
ZODIACTRIM68
Ontologies - Pathways
QuickGOQ6AZZ1
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  cytosol  zinc ion binding  regulation of gene expression  positive regulation of autophagy  protein ubiquitination  protein kinase binding  regulation of protein localization  histone acetyltransferase binding  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  regulation of viral entry into host cell  perinuclear region of cytoplasm  androgen receptor binding  positive regulation of NF-kappaB transcription factor activity  protein autoubiquitination  interferon-gamma-mediated signaling pathway  regulation of androgen receptor signaling pathway  ubiquitin protein ligase activity  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  cytosol  zinc ion binding  regulation of gene expression  positive regulation of autophagy  protein ubiquitination  protein kinase binding  regulation of protein localization  histone acetyltransferase binding  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  regulation of viral entry into host cell  perinuclear region of cytoplasm  androgen receptor binding  positive regulation of NF-kappaB transcription factor activity  protein autoubiquitination  interferon-gamma-mediated signaling pathway  regulation of androgen receptor signaling pathway  ubiquitin protein ligase activity  
NDEx NetworkTRIM68
Atlas of Cancer Signalling NetworkTRIM68
Wikipedia pathwaysTRIM68
Orthology - Evolution
OrthoDB55128
GeneTree (enSembl)ENSG00000167333
Phylogenetic Trees/Animal Genes : TreeFamTRIM68
HOGENOMQ6AZZ1
Homologs : HomoloGeneTRIM68
Homology/Alignments : Family Browser (UCSC)TRIM68
Gene fusions - Rearrangements
Fusion : QuiverTRIM68
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM68 [hg38]
dbVarTRIM68
ClinVarTRIM68
MonarchTRIM68
1000_GenomesTRIM68 
Exome Variant ServerTRIM68
GNOMAD BrowserENSG00000167333
Varsome BrowserTRIM68
Genomic Variants (DGV)TRIM68 [DGVbeta]
DECIPHERTRIM68 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIM68 
Mutations
ICGC Data PortalTRIM68 
TCGA Data PortalTRIM68 
Broad Tumor PortalTRIM68
OASIS PortalTRIM68 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM68  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRIM68
Mutations and Diseases : HGMDTRIM68
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIM68
DgiDB (Drug Gene Interaction Database)TRIM68
DoCM (Curated mutations)TRIM68 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIM68 (select a term)
intoGenTRIM68
Cancer3DTRIM68(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613184   
Orphanet
DisGeNETTRIM68
MedgenTRIM68
Genetic Testing Registry TRIM68
NextProtQ6AZZ1 [Medical]
GENETestsTRIM68
Target ValidationTRIM68
Huge Navigator TRIM68 [HugePedia]
ClinGenTRIM68
Clinical trials, drugs, therapy
MyCancerGenomeTRIM68
Protein Interactions : CTD
Pharm GKB GenePA134939870
PharosQ6AZZ1
Clinical trialTRIM68
Miscellaneous
canSAR (ICR)TRIM68 (select the gene name)
HarmonizomeTRIM68
DataMed IndexTRIM68
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRIM68
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jan 1 18:42:28 CET 2021
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