TRIM68 (tripartite motif containing 68)

2003-10-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
GC109,RNF137,SS-56,SS56
FUSION GENES

Other Information

Locus ID:

NCBI: 55128
MIM: 613184
HGNC: 21161
Ensembl: ENSG00000167333

Variants:

dbSNP: 55128
ClinVar: 55128
TCGA: ENSG00000167333
COSMIC: TRIM68

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167333ENST00000300747Q6AZZ1
ENSG00000167333ENST00000526337E9PP83
ENSG00000167333ENST00000531101E9PJJ9
ENSG00000167333ENST00000533021E9PR29

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
184511772008TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.16
249999932014TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems.9
197953992009Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.6

Citation

Dessen P

TRIM68 (tripartite motif containing 68)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/42129/trim68