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TRIM69 (tripartite motif containing 69)

Identity

Alias (NCBI)HSD-34
HSD34
RNF36
Trif
HGNC (Hugo) TRIM69
HGNC Alias symbTrif
TRIMLESS
HGNC Previous nameRNF36
HGNC Previous namering finger protein 36
 tripartite motif-containing 69
LocusID (NCBI) 140691
Atlas_Id 75180
Location 15q21.1  [Link to chromosome band 15q21]
Location_base_pair Starts at 44736528 and ends at 44767827 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CREBBP (16p13.3) / TRIM69 (15q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(15;16)(q21;p13) CREBBP/TRIM69
t(15;16)(q21;p13) CREBBP/TRIM69


External links

 

Nomenclature
HGNC (Hugo)TRIM69   17857
Cards
Entrez_Gene (NCBI)TRIM69    tripartite motif containing 69
AliasesHSD-34; HSD34; RNF36; Trif
GeneCards (Weizmann)TRIM69
Ensembl hg19 (Hinxton)ENSG00000185880 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185880 [Gene_View]  ENSG00000185880 [Sequence]  chr15:44736528-44767827 [Contig_View]  TRIM69 [Vega]
ICGC DataPortalENSG00000185880
TCGA cBioPortalTRIM69
AceView (NCBI)TRIM69
Genatlas (Paris)TRIM69
SOURCE (Princeton)TRIM69
Genetics Home Reference (NIH)TRIM69
Genomic and cartography
GoldenPath hg38 (UCSC)TRIM69  -     chr15:44736528-44767827 +  15q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIM69  -     15q21.1   [Description]    (hg19-Feb_2009)
GoldenPathTRIM69 - 15q21.1 [CytoView hg19]  TRIM69 - 15q21.1 [CytoView hg38]
ImmunoBaseENSG00000185880
Genome Data Viewer NCBITRIM69 [Mapview hg19]  
OMIM616017   
Gene and transcription
Genbank (Entrez)AF302088 AF302089 AK226115 AK292252 AL360161
RefSeq transcript (Entrez)NM_001301144 NM_001301145 NM_001301146 NM_080745 NM_182985
Consensus coding sequences : CCDS (NCBI)TRIM69
Gene ExpressionTRIM69 [ NCBI-GEO ]   TRIM69 [ EBI - ARRAY_EXPRESS ]   TRIM69 [ SEEK ]   TRIM69 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM69 [ Firebrowse - Broad ]
GenevisibleExpression of TRIM69 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)140691
GTEX Portal (Tissue expression)TRIM69
Human Protein AtlasENSG00000185880-TRIM69 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86WT6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86WT6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86WT6
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ86WT6
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)B30.2/SPRY    B30.2/SPRY_sf    Butyrophylin_SPRY    ConA-like_dom_sf    PRY    SPRY_dom    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)PRY (PF13765)    SPRY (PF00622)   
Domain families : Pfam (NCBI)pfam13765    pfam00622   
Domain families : Smart (EMBL)PRY (SM00589)  RING (SM00184)  SPRY (SM00449)  
Conserved Domain (NCBI)TRIM69
PDB (RSDB)4NQJ    6YXE   
PDB Europe4NQJ    6YXE   
PDB (PDBSum)4NQJ    6YXE   
PDB (IMB)4NQJ    6YXE   
Structural Biology KnowledgeBase4NQJ    6YXE   
SCOP (Structural Classification of Proteins)4NQJ    6YXE   
CATH (Classification of proteins structures)4NQJ    6YXE   
SuperfamilyQ86WT6
AlphaFold pdb e-kbQ86WT6   
Human Protein Atlas [tissue]ENSG00000185880-TRIM69 [tissue]
HPRD11518
Protein Interaction databases
DIP (DOE-UCLA)Q86WT6
IntAct (EBI)Q86WT6
BioGRIDTRIM69
STRING (EMBL)TRIM69
ZODIACTRIM69
Ontologies - Pathways
QuickGOQ86WT6
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  apoptotic process  protein ubiquitination  nuclear speck  metal ion binding  ubiquitin protein ligase activity  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  apoptotic process  protein ubiquitination  nuclear speck  metal ion binding  ubiquitin protein ligase activity  
NDEx NetworkTRIM69
Atlas of Cancer Signalling NetworkTRIM69
Wikipedia pathwaysTRIM69
Orthology - Evolution
OrthoDB140691
GeneTree (enSembl)ENSG00000185880
Phylogenetic Trees/Animal Genes : TreeFamTRIM69
Homologs : HomoloGeneTRIM69
Homology/Alignments : Family Browser (UCSC)TRIM69
Gene fusions - Rearrangements
Fusion : QuiverTRIM69
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM69 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM69
dbVarTRIM69
ClinVarTRIM69
MonarchTRIM69
1000_GenomesTRIM69 
Exome Variant ServerTRIM69
GNOMAD BrowserENSG00000185880
Varsome BrowserTRIM69
ACMGTRIM69 variants
VarityQ86WT6
Genomic Variants (DGV)TRIM69 [DGVbeta]
DECIPHERTRIM69 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIM69 
Mutations
ICGC Data PortalTRIM69 
TCGA Data PortalTRIM69 
Broad Tumor PortalTRIM69
OASIS PortalTRIM69 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM69  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRIM69
Mutations and Diseases : HGMDTRIM69
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRIM69
DgiDB (Drug Gene Interaction Database)TRIM69
DoCM (Curated mutations)TRIM69
CIViC (Clinical Interpretations of Variants in Cancer)TRIM69
Cancer3DTRIM69
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616017   
Orphanet
DisGeNETTRIM69
MedgenTRIM69
Genetic Testing Registry TRIM69
NextProtQ86WT6 [Medical]
GENETestsTRIM69
Target ValidationTRIM69
Huge Navigator TRIM69 [HugePedia]
ClinGenTRIM69
Clinical trials, drugs, therapy
MyCancerGenomeTRIM69
Protein Interactions : CTDTRIM69
Pharm GKB GenePA162407010
PharosQ86WT6
Clinical trialTRIM69
Miscellaneous
canSAR (ICR)TRIM69
HarmonizomeTRIM69
DataMed IndexTRIM69
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRIM69
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:26:59 CEST 2021

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