TRIM69 (tripartite motif containing 69)

2014-11-01  

Identity

HGNC
LOCATION
15q21.1
LOCUSID
ALIAS
HSD-34,HSD34,RNF36,Trif
FUSION GENES

Other Information

Locus ID:

NCBI: 140691
MIM: 616017
HGNC: 17857
Ensembl: ENSG00000185880

Variants:

dbSNP: 140691
ClinVar: 140691
TCGA: ENSG00000185880
COSMIC: TRIM69

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185880ENST00000329464Q86WT6
ENSG00000185880ENST00000338264Q86WT6
ENSG00000185880ENST00000558329Q86WT6
ENSG00000185880ENST00000559390Q86WT6
ENSG00000185880ENST00000560442Q86WT6
ENSG00000185880ENST00000561043H0YL66
ENSG00000185880ENST00000561170H0YKB8

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
301422142018Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3.9
231315562012Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation.4
308446442019TRIM69 inhibits cataractogenesis by negatively regulating p53.3
313755752019TRIM69 Inhibits Vesicular Stomatitis Indiana Virus.2
115788782001A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis.1

Citation

Dessen P

TRIM69 (tripartite motif containing 69)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75180/trim69