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TRIM72 (tripartite motif containing 72)

Identity

Alias (NCBI)MG53
HGNC (Hugo) TRIM72
HGNC Alias symbMG53
HGNC Alias namemitsugumin 53
HGNC Previous nametripartite motif-containing 72
 tripartite motif containing 72, E3 ubiquitin protein ligase
LocusID (NCBI) 493829
Atlas_Id 51078
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 31214119 and ends at 31231537 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TRIM72   32671
Cards
Entrez_Gene (NCBI)TRIM72  493829  tripartite motif containing 72
AliasesMG53
GeneCards (Weizmann)TRIM72
Ensembl hg19 (Hinxton)ENSG00000177238 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177238 [Gene_View]  ENSG00000177238 [Sequence]  chr16:31214119-31231537 [Contig_View]  TRIM72 [Vega]
ICGC DataPortalENSG00000177238
TCGA cBioPortalTRIM72
AceView (NCBI)TRIM72
Genatlas (Paris)TRIM72
WikiGenes493829
SOURCE (Princeton)TRIM72
Genetics Home Reference (NIH)TRIM72
Genomic and cartography
GoldenPath hg38 (UCSC)TRIM72  -     chr16:31214119-31231537 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIM72  -     16p11.2   [Description]    (hg19-Feb_2009)
GoldenPathTRIM72 - 16p11.2 [CytoView hg19]  TRIM72 - 16p11.2 [CytoView hg38]
ImmunoBaseENSG00000177238
genome Data Viewer NCBITRIM72 [Mapview hg19]  
OMIM613288   
Gene and transcription
Genbank (Entrez)AK090695 AK131485 BC033211 DA058421 DA821604
RefSeq transcript (Entrez)NM_001008274
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRIM72
Alternative Splicing GalleryENSG00000177238
Gene ExpressionTRIM72 [ NCBI-GEO ]   TRIM72 [ EBI - ARRAY_EXPRESS ]   TRIM72 [ SEEK ]   TRIM72 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM72 [ Firebrowse - Broad ]
GenevisibleExpression of TRIM72 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)493829
GTEX Portal (Tissue expression)TRIM72
Human Protein AtlasENSG00000177238-TRIM72 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZMU5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZMU5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZMU5
Splice isoforms : SwissVarQ6ZMU5
PhosPhoSitePlusQ6ZMU5
Domaine pattern : Prosite (Expaxy)B302_SPRY (PS50188)    ZF_BBOX (PS50119)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)B30.2/SPRY    Butyrophylin_SPRY    ConA-like_dom_sf    PRY    SPRY_dom    TRIM72    Znf-RING_LisH    Znf_B-box    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)PRY (PF13765)    SPRY (PF00622)    zf-B_box (PF00643)    zf-RING_UBOX (PF13445)   
Domain families : Pfam (NCBI)pfam13765    pfam00622    pfam00643    pfam13445   
Domain families : Smart (EMBL)BBOX (SM00336)  PRY (SM00589)  RING (SM00184)  SPRY (SM00449)  
Conserved Domain (NCBI)TRIM72
DMDM Disease mutations493829
Blocks (Seattle)TRIM72
PDB (RSDB)3KB5   
PDB Europe3KB5   
PDB (PDBSum)3KB5   
PDB (IMB)3KB5   
Structural Biology KnowledgeBase3KB5   
SCOP (Structural Classification of Proteins)3KB5   
CATH (Classification of proteins structures)3KB5   
SuperfamilyQ6ZMU5
Human Protein Atlas [tissue]ENSG00000177238-TRIM72 [tissue]
Peptide AtlasQ6ZMU5
HPRD17412
IPIIPI00301028   IPI00789174   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZMU5
IntAct (EBI)Q6ZMU5
FunCoupENSG00000177238
BioGRIDTRIM72
STRING (EMBL)TRIM72
ZODIACTRIM72
Ontologies - Pathways
QuickGOQ6ZMU5
Ontology : AmiGOplasma membrane repair  phosphatidylserine binding  muscle system process  protein binding  cytoplasm  exocytosis  muscle contraction  muscle organ development  zinc ion binding  negative regulation of myotube differentiation  protein ubiquitination  cytoplasmic vesicle membrane  cytoplasmic vesicle membrane  ubiquitin conjugating enzyme binding  sarcolemma  sarcolemma  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of insulin-like growth factor receptor signaling pathway  negative regulation of insulin receptor signaling pathway  protein homooligomerization  ubiquitin protein ligase activity  
Ontology : EGO-EBIplasma membrane repair  phosphatidylserine binding  muscle system process  protein binding  cytoplasm  exocytosis  muscle contraction  muscle organ development  zinc ion binding  negative regulation of myotube differentiation  protein ubiquitination  cytoplasmic vesicle membrane  cytoplasmic vesicle membrane  ubiquitin conjugating enzyme binding  sarcolemma  sarcolemma  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of insulin-like growth factor receptor signaling pathway  negative regulation of insulin receptor signaling pathway  protein homooligomerization  ubiquitin protein ligase activity  
NDEx NetworkTRIM72
Atlas of Cancer Signalling NetworkTRIM72
Wikipedia pathwaysTRIM72
Orthology - Evolution
OrthoDB493829
GeneTree (enSembl)ENSG00000177238
Phylogenetic Trees/Animal Genes : TreeFamTRIM72
HOGENOMQ6ZMU5
Homologs : HomoloGeneTRIM72
Homology/Alignments : Family Browser (UCSC)TRIM72
Gene fusions - Rearrangements
Fusion : QuiverTRIM72
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM72 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM72
dbVarTRIM72
ClinVarTRIM72
1000_GenomesTRIM72 
Exome Variant ServerTRIM72
GNOMAD BrowserENSG00000177238
Varsome BrowserTRIM72
Genetic variants : HAPMAP493829
Genomic Variants (DGV)TRIM72 [DGVbeta]
DECIPHERTRIM72 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIM72 
Mutations
ICGC Data PortalTRIM72 
TCGA Data PortalTRIM72 
Broad Tumor PortalTRIM72
OASIS PortalTRIM72 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM72  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRIM72
Mutations and Diseases : HGMDTRIM72
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIM72
DgiDB (Drug Gene Interaction Database)TRIM72
DoCM (Curated mutations)TRIM72 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIM72 (select a term)
intoGenTRIM72
Cancer3DTRIM72(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613288   
Orphanet
DisGeNETTRIM72
MedgenTRIM72
Genetic Testing Registry TRIM72
NextProtQ6ZMU5 [Medical]
TSGene493829
GENETestsTRIM72
Target ValidationTRIM72
Huge Navigator TRIM72 [HugePedia]
snp3D : Map Gene to Disease493829
BioCentury BCIQTRIM72
ClinGenTRIM72
Clinical trials, drugs, therapy
Protein Interactions : CTD493829
Pharm GKB GenePA144596247
Clinical trialTRIM72
Miscellaneous
canSAR (ICR)TRIM72 (select the gene name)
HarmonizomeTRIM72
DataMed IndexTRIM72
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIM72
EVEXTRIM72
GoPubMedTRIM72
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:40:42 CEST 2020
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