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TRIM8 (tripartite motif containing 8)

Identity

Other namesGERP
RNF27
HGNC (Hugo) TRIM8
LocusID (NCBI) 81603
Atlas_Id 42704
Location 10q24.32
Location_base_pair Starts at 104404252 and ends at 104418076 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FKBP2 (11q13.1) / TRIM8 (10q24.32)HSPBP1 (19q13.42) / TRIM8 (10q24.32)WBP1L (10q24.32) / TRIM8 (10q24.32)
C10orf26 TRIM8 10q24.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRIM8   15579
Cards
Entrez_Gene (NCBI)TRIM8  81603  tripartite motif containing 8
GeneCards (Weizmann)TRIM8
Ensembl hg19 (Hinxton)ENSG00000171206 [Gene_View]  chr10:104404252-104418076 [Contig_View]  TRIM8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000171206 [Gene_View]  chr10:104404252-104418076 [Contig_View]  TRIM8 [Vega]
ICGC DataPortalENSG00000171206
TCGA cBioPortalTRIM8
AceView (NCBI)TRIM8
Genatlas (Paris)TRIM8
WikiGenes81603
SOURCE (Princeton)TRIM8
Genomic and cartography
GoldenPath hg19 (UCSC)TRIM8  -     chr10:104404252-104418076 +  10q24.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TRIM8  -     10q24.32   [Description]    (hg38-Dec_2013)
EnsemblTRIM8 - 10q24.32 [CytoView hg19]  TRIM8 - 10q24.32 [CytoView hg38]
Mapping of homologs : NCBITRIM8 [Mapview hg19]  TRIM8 [Mapview hg38]
OMIM606125   
Gene and transcription
Genbank (Entrez)AA907931 AF086326 AF220034 AF281046 AL360160
RefSeq transcript (Entrez)NM_030912
RefSeq genomic (Entrez)NC_000010 NC_018921 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)TRIM8
Cluster EST : UnigeneHs.336810 [ NCBI ]
CGAP (NCI)Hs.336810
Alternative Splicing GalleryENSG00000171206
Gene ExpressionTRIM8 [ NCBI-GEO ]   TRIM8 [ EBI - ARRAY_EXPRESS ]   TRIM8 [ SEEK ]   TRIM8 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81603
GTEX Portal (Tissue expression)TRIM8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZR9 (Uniprot)
NextProtQ9BZR9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZR9
Splice isoforms : SwissVarQ9BZR9 (Swissvar)
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ9BZR9
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)RING (SM00184)  
DMDM Disease mutations81603
Blocks (Seattle)TRIM8
SuperfamilyQ9BZR9
Human Protein AtlasENSG00000171206
Peptide AtlasQ9BZR9
HPRD06934
IPIIPI00289207   
Protein Interaction databases
DIP (DOE-UCLA)Q9BZR9
IntAct (EBI)Q9BZR9
FunCoupENSG00000171206
BioGRIDTRIM8
STRING (EMBL)TRIM8
ZODIACTRIM8
Ontologies - Pathways
QuickGOQ9BZR9
Ontology : AmiGOnucleoplasm  cytoplasm  cytosol  zinc ion binding  positive regulation of autophagy  protein ubiquitination  PML body  ligase activity  stem cell population maintenance  negative regulation of viral transcription  identical protein binding  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  intracellular membrane-bounded organelle  innate immune response  negative regulation of viral entry into host cell  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  interferon-gamma-mediated signaling pathway  positive regulation of protein localization to nucleus  negative regulation of viral release from host cell  
Ontology : EGO-EBInucleoplasm  cytoplasm  cytosol  zinc ion binding  positive regulation of autophagy  protein ubiquitination  PML body  ligase activity  stem cell population maintenance  negative regulation of viral transcription  identical protein binding  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  intracellular membrane-bounded organelle  innate immune response  negative regulation of viral entry into host cell  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  interferon-gamma-mediated signaling pathway  positive regulation of protein localization to nucleus  negative regulation of viral release from host cell  
NDEx Network
Atlas of Cancer Signalling NetworkTRIM8
Wikipedia pathwaysTRIM8
Orthology - Evolution
OrthoDB81603
GeneTree (enSembl)ENSG00000171206
Phylogenetic Trees/Animal Genes : TreeFamTRIM8
Homologs : HomoloGeneTRIM8
Homology/Alignments : Family Browser (UCSC)TRIM8
Gene fusions - Rearrangements
Fusion: TCGAC10orf26 TRIM8 10q24.32 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerTRIM8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM8
dbVarTRIM8
ClinVarTRIM8
1000_GenomesTRIM8 
Exome Variant ServerTRIM8
ExAC (Exome Aggregation Consortium)TRIM8 (select the gene name)
Genetic variants : HAPMAP81603
Genomic Variants (DGV)TRIM8 [DGVbeta]
Mutations
ICGC Data PortalTRIM8 
TCGA Data PortalTRIM8 
Broad Tumor PortalTRIM8
OASIS PortalTRIM8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM8 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIM8
DgiDB (Drug Gene Interaction Database)TRIM8
DoCM (Curated mutations)TRIM8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIM8 (select a term)
intoGenTRIM8
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)10:104404252-104418076  ENSG00000171206
CONAN: Copy Number AnalysisTRIM8 
Mutations and Diseases : HGMDTRIM8
OMIM606125   
MedgenTRIM8
Genetic Testing Registry TRIM8
NextProtQ9BZR9 [Medical]
TSGene81603
GENETestsTRIM8
Huge Navigator TRIM8 [HugePedia]
snp3D : Map Gene to Disease81603
BioCentury BCIQTRIM8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD81603
Chemical/Pharm GKB GenePA37983
Clinical trialTRIM8
Miscellaneous
canSAR (ICR)TRIM8 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIM8
EVEXTRIM8
GoPubMedTRIM8
iHOPTRIM8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 19:10:00 CEST 2016

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