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TRIM8 (tripartite motif containing 8)

Identity

Alias (NCBI)GERP
RNF27
HGNC (Hugo) TRIM8
HGNC Alias symbGERP
HGNC Alias nameglioblastoma expressed ring finger protein
HGNC Previous nameRNF27
HGNC Previous namering finger protein 27
 tripartite motif-containing 8
LocusID (NCBI) 81603
Atlas_Id 42704
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 102644495 and ends at 102658319 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FKBP2 (11q13.1) / TRIM8 (10q24.32)HSPBP1 (19q13.42) / TRIM8 (10q24.32)WBP1L (10q24.32) / TRIM8 (10q24.32)
C10orf26 TRIM8 10q24.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TRIM8   15579
Cards
Entrez_Gene (NCBI)TRIM8    tripartite motif containing 8
AliasesGERP; RNF27
GeneCards (Weizmann)TRIM8
Ensembl hg19 (Hinxton)ENSG00000171206 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171206 [Gene_View]  ENSG00000171206 [Sequence]  chr10:102644495-102658319 [Contig_View]  TRIM8 [Vega]
ICGC DataPortalENSG00000171206
TCGA cBioPortalTRIM8
AceView (NCBI)TRIM8
Genatlas (Paris)TRIM8
SOURCE (Princeton)TRIM8
Genetics Home Reference (NIH)TRIM8
Genomic and cartography
GoldenPath hg38 (UCSC)TRIM8  -     chr10:102644495-102658319 +  10q24.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIM8  -     10q24.32   [Description]    (hg19-Feb_2009)
GoldenPathTRIM8 - 10q24.32 [CytoView hg19]  TRIM8 - 10q24.32 [CytoView hg38]
ImmunoBaseENSG00000171206
Genome Data Viewer NCBITRIM8 [Mapview hg19]  
OMIM606125   
Gene and transcription
Genbank (Entrez)AA907931 AF086326 AF220034 AF281046 AL360160
RefSeq transcript (Entrez)NM_001345950 NM_030912
Consensus coding sequences : CCDS (NCBI)TRIM8
Gene ExpressionTRIM8 [ NCBI-GEO ]   TRIM8 [ EBI - ARRAY_EXPRESS ]   TRIM8 [ SEEK ]   TRIM8 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM8 [ Firebrowse - Broad ]
GenevisibleExpression of TRIM8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81603
GTEX Portal (Tissue expression)TRIM8
Human Protein AtlasENSG00000171206-TRIM8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZR9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZR9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZR9
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9BZR9
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)TRIM8
SuperfamilyQ9BZR9
AlphaFold pdb e-kbQ9BZR9   
Human Protein Atlas [tissue]ENSG00000171206-TRIM8 [tissue]
HPRD06934
Protein Interaction databases
DIP (DOE-UCLA)Q9BZR9
IntAct (EBI)Q9BZR9
BioGRIDTRIM8
STRING (EMBL)TRIM8
ZODIACTRIM8
Ontologies - Pathways
QuickGOQ9BZR9
Ontology : AmiGOtranscription coactivator activity  protein binding  cytosol  zinc ion binding  positive regulation of autophagy  protein ubiquitination  PML body  transferase activity  stem cell population maintenance  negative regulation of viral transcription  identical protein binding  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  positive regulation of transcription, DNA-templated  negative regulation of viral entry into host cell  positive regulation of DNA-binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  interferon-gamma-mediated signaling pathway  positive regulation of protein localization to nucleus  negative regulation of viral release from host cell  
Ontology : EGO-EBItranscription coactivator activity  protein binding  cytosol  zinc ion binding  positive regulation of autophagy  protein ubiquitination  PML body  transferase activity  stem cell population maintenance  negative regulation of viral transcription  identical protein binding  protein homodimerization activity  positive regulation of I-kappaB kinase/NF-kappaB signaling  innate immune response  positive regulation of transcription, DNA-templated  negative regulation of viral entry into host cell  positive regulation of DNA-binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  interferon-gamma-mediated signaling pathway  positive regulation of protein localization to nucleus  negative regulation of viral release from host cell  
NDEx NetworkTRIM8
Atlas of Cancer Signalling NetworkTRIM8
Wikipedia pathwaysTRIM8
Orthology - Evolution
OrthoDB81603
GeneTree (enSembl)ENSG00000171206
Phylogenetic Trees/Animal Genes : TreeFamTRIM8
Homologs : HomoloGeneTRIM8
Homology/Alignments : Family Browser (UCSC)TRIM8
Gene fusions - Rearrangements
Fusion : MitelmanWBP1L/TRIM8 [10q24.32/10q24.32]  
Fusion : QuiverTRIM8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM8
dbVarTRIM8
ClinVarTRIM8
MonarchTRIM8
1000_GenomesTRIM8 
Exome Variant ServerTRIM8
GNOMAD BrowserENSG00000171206
Varsome BrowserTRIM8
ACMGTRIM8 variants
VarityQ9BZR9
Genomic Variants (DGV)TRIM8 [DGVbeta]
DECIPHERTRIM8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIM8 
Mutations
ICGC Data PortalTRIM8 
TCGA Data PortalTRIM8 
Broad Tumor PortalTRIM8
OASIS PortalTRIM8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRIM8
Mutations and Diseases : HGMDTRIM8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRIM8
DgiDB (Drug Gene Interaction Database)TRIM8
DoCM (Curated mutations)TRIM8
CIViC (Clinical Interpretations of Variants in Cancer)TRIM8
Cancer3DTRIM8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606125   
Orphanet
DisGeNETTRIM8
MedgenTRIM8
Genetic Testing Registry TRIM8
NextProtQ9BZR9 [Medical]
GENETestsTRIM8
Target ValidationTRIM8
Huge Navigator TRIM8 [HugePedia]
ClinGenTRIM8
Clinical trials, drugs, therapy
MyCancerGenomeTRIM8
Protein Interactions : CTDTRIM8
Pharm GKB GenePA37983
PharosQ9BZR9
Clinical trialTRIM8
Miscellaneous
canSAR (ICR)TRIM8
HarmonizomeTRIM8
DataMed IndexTRIM8
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRIM8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:26 CEST 2021

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