TRIOBP (TRIO and F-actin binding protein)

2015-03-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
DFNB28,HRIHFB2122,TAP68,TARA,dJ37E16.4
FUSION GENES

Other Information

Locus ID:

NCBI: 11078
MIM: 609761
HGNC: 17009
Ensembl: ENSG00000100106

Variants:

dbSNP: 11078
ClinVar: 11078
TCGA: ENSG00000100106
COSMIC: TRIOBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100106ENST00000344404H7BXW4
ENSG00000100106ENST00000403663Q9H2D6
ENSG00000100106ENST00000407319Q9H2D6
ENSG00000100106ENST00000413051H0Y5T8
ENSG00000100106ENST00000417857F6WYE2
ENSG00000100106ENST00000418339F6TR96
ENSG00000100106ENST00000428075H0Y5J9
ENSG00000100106ENST00000452519F6WMF4
ENSG00000100106ENST00000644935Q9H2D6

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
163854582006Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss.44
163854572006Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness.34
277640962016A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records.19
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
181946652008The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara.9
251301702015The actin-bundling protein TRIOBP-4 and -5 promotes the motility of pancreatic cancer cells.9
253338792014Aggregation of the protein TRIOBP-1 and its potential relevance to schizophrenia.8
284388372017An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure.8
199962802009Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity.7

Citation

Dessen P

TRIOBP (TRIO and F-actin binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55136/triobp