TRIP12 (thyroid hormone receptor interactor 12)

2012-04-01  

Identity

HGNC
LOCATION
2q36.3
LOCUSID
ALIAS
MRD49,TRIP-12,TRIPC,ULF
FUSION GENES

Other Information

Locus ID:

NCBI: 9320
MIM: 604506
HGNC: 12306
Ensembl: ENSG00000153827

Variants:

dbSNP: 9320
ClinVar: 9320
TCGA: ENSG00000153827
COSMIC: TRIP12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153827ENST00000283943Q14669
ENSG00000153827ENST00000343290F8W9P3
ENSG00000153827ENST00000389044Q14669
ENSG00000153827ENST00000389045Q14669
ENSG00000153827ENST00000409677G5E9G6
ENSG00000153827ENST00000418123H7C2Y1
ENSG00000153827ENST00000428959C9JLJ5
ENSG00000153827ENST00000430954C9JLD7
ENSG00000153827ENST00000435716C9JSX9
ENSG00000153827ENST00000453485H7C1L9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
228846922012TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.132
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
190286812009The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway.27
208293582010Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex.19
186277662008TRIP12 functions as an E3 ubiquitin ligase of APP-BP1.15
278006092016Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response.12
206996392010Reactivating the ARF-p53 axis in AML cells by targeting ULF.10
232097762012HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitin.10
225613472012TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation.9

Citation

Dessen P

TRIP12 (thyroid hormone receptor interactor 12)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52672/trip12