TRIP4 (thyroid hormone receptor interactor 4)

2019-04-01  

Identity

HGNC
TRIP4
LOCATION
15q22.31
LOCUSID
9325
ALIAS
ASC-1,ASC1,HsT17391,MDCDC,SMABF1,ZC2HC5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9325
MIM: 604501
HGNC: 12310
Ensembl: ENSG00000103671

Variants:

dbSNP: 9325
ClinVar: 9325
TCGA: ENSG00000103671
COSMIC: TRIP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103671ENST00000261884Q15650
ENSG00000103671ENST00000558162H0YKD9
ENSG00000103671ENST00000558820H0YK63
ENSG00000103671ENST00000560475H3BMU9
ENSG00000103671ENST00000560567H0YL91
ENSG00000103671ENST00000560920H0YLN7

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
244959692014Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene.32
190746422009Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1.8
309058202019TRIP4 promotes tumor growth and metastasis and regulates radiosensitivity of cervical cancer by activating MAPK, PI3K/AKT, and hTERT signaling.5
270088872016The transcription coactivator ASC-1 is a regulator of skeletal myogenesis, and its deficiency causes a novel form of congenital muscle disease.3
288996852018The Tumor-Promoting Role of TRIP4 in Melanoma Progression and its Involvement in Response to BRAF-Targeted Therapy.0
317940732020ASC-1 Is a Cell Cycle Regulator Associated with Severe and Mild Forms of Myopathy.0

Citation

Dessen P

TRIP4 (thyroid hormone receptor interactor 4)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57883/trip4