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TRIT1 (tRNA isopentenyltransferase 1)

Identity

Alias_symbol (synonym)FLJ20061
IPT
Other aliasCOXPD35
GRO1
IPPT
IPTase
MOD5
hGRO1
HGNC (Hugo) TRIT1
LocusID (NCBI) 54802
Atlas_Id 53605
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 39841031 and ends at 39883511 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COL1A1 (17q21.33) / TRIT1 (1p34.2)RLF (1p34.2) / TRIT1 (1p34.2)TRIT1 (1p34.2) / EP400 (12q24.33)
TRIT1 (1p34.2) / MYCL (1p34.2)TRIT1 (1p34.2) / PPIE (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Small Cell Carcinoma
t(1;12)(p34;q24) TRIT1/EP400


External links

Nomenclature
HGNC (Hugo)TRIT1   20286
Cards
Entrez_Gene (NCBI)TRIT1  54802  tRNA isopentenyltransferase 1
AliasesCOXPD35; GRO1; IPPT; IPT; 
IPTase; MOD5; hGRO1
GeneCards (Weizmann)TRIT1
Ensembl hg19 (Hinxton)ENSG00000043514 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000043514 [Gene_View]  ENSG00000043514 [Sequence]  chr1:39841031-39883511 [Contig_View]  TRIT1 [Vega]
ICGC DataPortalENSG00000043514
TCGA cBioPortalTRIT1
AceView (NCBI)TRIT1
Genatlas (Paris)TRIT1
WikiGenes54802
SOURCE (Princeton)TRIT1
Genetics Home Reference (NIH)TRIT1
Genomic and cartography
GoldenPath hg38 (UCSC)TRIT1  -     chr1:39841031-39883511 -  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIT1  -     1p34.2   [Description]    (hg19-Feb_2009)
GoldenPathTRIT1 - 1p34.2 [CytoView hg19]  TRIT1 - 1p34.2 [CytoView hg38]
ImmunoBaseENSG00000043514
Mapping of homologs : NCBITRIT1 [Mapview hg19]  TRIT1 [Mapview hg38]
OMIM617840   617873   
Gene and transcription
Genbank (Entrez)AF074918 AK000068 AK074222 AK223478 AK296453
RefSeq transcript (Entrez)NM_001312691 NM_001312692 NM_017646
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRIT1
Cluster EST : UnigeneHs.356554 [ NCBI ]
CGAP (NCI)Hs.356554
Alternative Splicing GalleryENSG00000043514
Gene ExpressionTRIT1 [ NCBI-GEO ]   TRIT1 [ EBI - ARRAY_EXPRESS ]   TRIT1 [ SEEK ]   TRIT1 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54802
GTEX Portal (Tissue expression)TRIT1
Human Protein AtlasENSG00000043514-TRIT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H3H1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H3H1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H3H1
Splice isoforms : SwissVarQ9H3H1
Catalytic activity : Enzyme2.5.1.75 [ Enzyme-Expasy ]   2.5.1.752.5.1.75 [ IntEnz-EBI ]   2.5.1.75 [ BRENDA ]   2.5.1.75 [ KEGG ]   
PhosPhoSitePlusQ9H3H1
Domains : Interpro (EBI)IPP_transferase_euk    IPT    Matrin/U1-like-C_Znf_C2H2    P-loop_NTPase    Znf_C2H2_jaz    Znf_C2H2_sf   
Domain families : Pfam (Sanger)IPPT (PF01715)    zf-C2H2_jaz (PF12171)   
Domain families : Pfam (NCBI)pfam01715    pfam12171   
Domain families : Smart (EMBL)ZnF_U1 (SM00451)  
Conserved Domain (NCBI)TRIT1
DMDM Disease mutations54802
Blocks (Seattle)TRIT1
SuperfamilyQ9H3H1
Human Protein Atlas [tissue]ENSG00000043514-TRIT1 [tissue]
Peptide AtlasQ9H3H1
HPRD18226
IPIIPI00783082   IPI00419305   IPI00419306   IPI00164286   IPI00513725   IPI01010128   IPI01010521   IPI01014271   IPI01011026   IPI01013375   
Protein Interaction databases
DIP (DOE-UCLA)Q9H3H1
IntAct (EBI)Q9H3H1
FunCoupENSG00000043514
BioGRIDTRIT1
STRING (EMBL)TRIT1
ZODIACTRIT1
Ontologies - Pathways
QuickGOQ9H3H1
Ontology : AmiGOnucleic acid binding  ATP binding  cellular_component  mitochondrion  mitochondrial matrix  tRNA modification  zinc ion binding  tRNA dimethylallyltransferase activity  tRNA dimethylallyltransferase activity  tRNA dimethylallyltransferase activity  mitochondrial tRNA modification  
Ontology : EGO-EBInucleic acid binding  ATP binding  cellular_component  mitochondrion  mitochondrial matrix  tRNA modification  zinc ion binding  tRNA dimethylallyltransferase activity  tRNA dimethylallyltransferase activity  tRNA dimethylallyltransferase activity  mitochondrial tRNA modification  
NDEx NetworkTRIT1
Atlas of Cancer Signalling NetworkTRIT1
Wikipedia pathwaysTRIT1
Orthology - Evolution
OrthoDB54802
GeneTree (enSembl)ENSG00000043514
Phylogenetic Trees/Animal Genes : TreeFamTRIT1
HOGENOMQ9H3H1
Homologs : HomoloGeneTRIT1
Homology/Alignments : Family Browser (UCSC)TRIT1
Gene fusions - Rearrangements
Fusion : MitelmanTRIT1/EP400 [1p34.2/12q24.33]  
Fusion : QuiverTRIT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIT1
dbVarTRIT1
ClinVarTRIT1
1000_GenomesTRIT1 
Exome Variant ServerTRIT1
ExAC (Exome Aggregation Consortium)ENSG00000043514
GNOMAD BrowserENSG00000043514
Varsome BrowserTRIT1
Genetic variants : HAPMAP54802
Genomic Variants (DGV)TRIT1 [DGVbeta]
DECIPHERTRIT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIT1 
Mutations
ICGC Data PortalTRIT1 
TCGA Data PortalTRIT1 
Broad Tumor PortalTRIT1
OASIS PortalTRIT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRIT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TRIT1
DgiDB (Drug Gene Interaction Database)TRIT1
DoCM (Curated mutations)TRIT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIT1 (select a term)
intoGenTRIT1
Cancer3DTRIT1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617840    617873   
Orphanet
DisGeNETTRIT1
MedgenTRIT1
Genetic Testing Registry TRIT1
NextProtQ9H3H1 [Medical]
TSGene54802
GENETestsTRIT1
Target ValidationTRIT1
Huge Navigator TRIT1 [HugePedia]
snp3D : Map Gene to Disease54802
BioCentury BCIQTRIT1
ClinGenTRIT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54802
Chemical/Pharm GKB GenePA134943037
Clinical trialTRIT1
Miscellaneous
canSAR (ICR)TRIT1 (select the gene name)
DataMed IndexTRIT1
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIT1
EVEXTRIT1
GoPubMedTRIT1
iHOPTRIT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 7 18:20:38 CEST 2019

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