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TRMT1 (tRNA methyltransferase 1)

Identity

Alias (NCBI)MRT68
TRM1
HGNC (Hugo) TRMT1
HGNC Alias symbFLJ20244
TRM1
HGNC Previous nametRNA methyltransferase 1 homolog (S. cerevisiae)
LocusID (NCBI) 55621
Atlas_Id 75193
Location 19p13.13  [Link to chromosome band 19p13]
Location_base_pair Starts at 13104900 and ends at 13116657 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TRMT1   25980
Cards
Entrez_Gene (NCBI)TRMT1    tRNA methyltransferase 1
AliasesMRT68; TRM1
GeneCards (Weizmann)TRMT1
Ensembl hg19 (Hinxton)ENSG00000104907 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104907 [Gene_View]  ENSG00000104907 [Sequence]  chr19:13104900-13116657 [Contig_View]  TRMT1 [Vega]
ICGC DataPortalENSG00000104907
TCGA cBioPortalTRMT1
AceView (NCBI)TRMT1
Genatlas (Paris)TRMT1
SOURCE (Princeton)TRMT1
Genetics Home Reference (NIH)TRMT1
Genomic and cartography
GoldenPath hg38 (UCSC)TRMT1  -     chr19:13104900-13116657 -  19p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRMT1  -     19p13.13   [Description]    (hg19-Feb_2009)
GoldenPathTRMT1 - 19p13.13 [CytoView hg19]  TRMT1 - 19p13.13 [CytoView hg38]
ImmunoBaseENSG00000104907
Genome Data Viewer NCBITRMT1 [Mapview hg19]  
OMIM611669   618302   
Gene and transcription
Genbank (Entrez)AF075055 AF196479 AK000251 AK292377 AK295245
RefSeq transcript (Entrez)NM_001136035 NM_001142554 NM_001351760 NM_001351761 NM_001351762 NM_017722
Consensus coding sequences : CCDS (NCBI)TRMT1
Gene ExpressionTRMT1 [ NCBI-GEO ]   TRMT1 [ EBI - ARRAY_EXPRESS ]   TRMT1 [ SEEK ]   TRMT1 [ MEM ]
Gene Expression Viewer (FireBrowse)TRMT1 [ Firebrowse - Broad ]
GenevisibleExpression of TRMT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55621
GTEX Portal (Tissue expression)TRMT1
Human Protein AtlasENSG00000104907-TRMT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NXH9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NXH9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NXH9
Catalytic activity : Enzyme2.1.1.216 [ Enzyme-Expasy ]   2.1.1.2162.1.1.216 [ IntEnz-EBI ]   2.1.1.216 [ BRENDA ]   2.1.1.216 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9NXH9
Domaine pattern : Prosite (Expaxy)SAM_MT_TRM1 (PS51626)    ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)SAM-dependent_MTases    Trm1    tRNA_met_Trm1_C    Znf_CCCH    Znf_CCCH_sf   
Domain families : Pfam (Sanger)TRM (PF02005)    zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam02005    pfam00642   
Domain families : Smart (EMBL)ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)TRMT1
SuperfamilyQ9NXH9
AlphaFold pdb e-kbQ9NXH9   
Human Protein Atlas [tissue]ENSG00000104907-TRMT1 [tissue]
HPRD08617
Protein Interaction databases
DIP (DOE-UCLA)Q9NXH9
IntAct (EBI)Q9NXH9
BioGRIDTRMT1
STRING (EMBL)TRMT1
ZODIACTRMT1
Ontologies - Pathways
QuickGOQ9NXH9
Ontology : AmiGOtRNA binding  tRNA N2-guanine methylation  RNA binding  tRNA (guanine-N2-)-methyltransferase activity  tRNA (guanine-N2-)-methyltransferase activity  protein binding  nucleus  nucleoplasm  tRNA modification  metal ion binding  
Ontology : EGO-EBItRNA binding  tRNA N2-guanine methylation  RNA binding  tRNA (guanine-N2-)-methyltransferase activity  tRNA (guanine-N2-)-methyltransferase activity  protein binding  nucleus  nucleoplasm  tRNA modification  metal ion binding  
NDEx NetworkTRMT1
Atlas of Cancer Signalling NetworkTRMT1
Wikipedia pathwaysTRMT1
Orthology - Evolution
OrthoDB55621
GeneTree (enSembl)ENSG00000104907
Phylogenetic Trees/Animal Genes : TreeFamTRMT1
Homologs : HomoloGeneTRMT1
Homology/Alignments : Family Browser (UCSC)TRMT1
Gene fusions - Rearrangements
Fusion : QuiverTRMT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRMT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRMT1
dbVarTRMT1
ClinVarTRMT1
MonarchTRMT1
1000_GenomesTRMT1 
Exome Variant ServerTRMT1
GNOMAD BrowserENSG00000104907
Varsome BrowserTRMT1
ACMGTRMT1 variants
VarityQ9NXH9
Genomic Variants (DGV)TRMT1 [DGVbeta]
DECIPHERTRMT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRMT1 
Mutations
ICGC Data PortalTRMT1 
TCGA Data PortalTRMT1 
Broad Tumor PortalTRMT1
OASIS PortalTRMT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRMT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRMT1
Mutations and Diseases : HGMDTRMT1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRMT1
DgiDB (Drug Gene Interaction Database)TRMT1
DoCM (Curated mutations)TRMT1
CIViC (Clinical Interpretations of Variants in Cancer)TRMT1
Cancer3DTRMT1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611669    618302   
Orphanet
DisGeNETTRMT1
MedgenTRMT1
Genetic Testing Registry TRMT1
NextProtQ9NXH9 [Medical]
GENETestsTRMT1
Target ValidationTRMT1
Huge Navigator TRMT1 [HugePedia]
ClinGenTRMT1
Clinical trials, drugs, therapy
MyCancerGenomeTRMT1
Protein Interactions : CTDTRMT1
Pharm GKB GenePA134867808
PharosQ9NXH9
Clinical trialTRMT1
Miscellaneous
canSAR (ICR)TRMT1
HarmonizomeTRMT1
DataMed IndexTRMT1
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRMT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 16:27:02 CEST 2021

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