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TRMT11 (tRNA methyltransferase 11 homolog)

Identity

Alias_namesC6orf75
chromosome 6 open reading frame 75
tRNA methyltransferase 11 homolog (S. cerevisiae)
Alias_symbol (synonym)MDS024
dJ187J11.2
TRM11
TRMT11-1
Other alias
HGNC (Hugo) TRMT11
LocusID (NCBI) 60487
Atlas_Id 52717
Location 6q22.32  [Link to chromosome band 6q22]
Location_base_pair Starts at 125986430 and ends at 126039274 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HAT1 (2q31.1) / TRMT11 (6q22.32)TPD52L1 (6q22.31) / TRMT11 (6q22.32)TRMT11 (6q22.32) / HINT3 (6q22.32)
TRMT11 (6q22.32) / ICK (6p12.2)TRMT11 (6q22.32) / NCOA7 (6q22.32)TRMT11 (6q22.32) / RNF217 (6q22.31)
TRMT11 (6q22.32) / SLC16A10 (6q21)TRMT11 6q22.32 / HINT3 6q22.32TRMT11 6q22.32 / ICK 6p12.2
TRMT11 6q22.32 / NCOA7 6q22.32TRMT11 6q22.32 / RNF217 6q22.31TRMT11 6q22.32 / SLC16A10 6q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  Lung: Translocations in Adenocarcinoma
t(6;6)(p12;q22) TRMT11/ICK
t(6;6)(q16;q22) TRMT11/GRIK2
t(6;6)(q21;q22) TRMT11/SLC16A10
TRMT11/HINT3 (6q22)
TRMT11/NCOA7 (6q22)
TRMT11/RNF217 (6q22)
TPD52L1/TRMT11 (6q22)


External links

Nomenclature
HGNC (Hugo)TRMT11   21080
Cards
Entrez_Gene (NCBI)TRMT11  60487  tRNA methyltransferase 11 homolog
AliasesC6orf75; MDS024; TRM11; TRMT11-1
GeneCards (Weizmann)TRMT11
Ensembl hg19 (Hinxton)ENSG00000066651 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000066651 [Gene_View]  ENSG00000066651 [Sequence]  chr6:125986430-126039274 [Contig_View]  TRMT11 [Vega]
ICGC DataPortalENSG00000066651
TCGA cBioPortalTRMT11
AceView (NCBI)TRMT11
Genatlas (Paris)TRMT11
WikiGenes60487
SOURCE (Princeton)TRMT11
Genetics Home Reference (NIH)TRMT11
Genomic and cartography
GoldenPath hg38 (UCSC)TRMT11  -     chr6:125986430-126039274 +  6q22.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRMT11  -     6q22.32   [Description]    (hg19-Feb_2009)
EnsemblTRMT11 - 6q22.32 [CytoView hg19]  TRMT11 - 6q22.32 [CytoView hg38]
Mapping of homologs : NCBITRMT11 [Mapview hg19]  TRMT11 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF182423 AF532977 AK308651 BC056878
RefSeq transcript (Entrez)NM_001031712 NM_001350580 NM_001350581 NM_001350582 NM_001350583 NM_001350584 NM_001350585 NM_001350586 NM_001350587 NM_001350588 NM_001350589 NM_001350590 NM_001350591 NM_001350592 NM_001350593 NM_001350594 NM_001350595 NM_001350596 NM_001350597 NM_021820
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRMT11
Cluster EST : UnigeneHs.404186 [ NCBI ]
CGAP (NCI)Hs.404186
Alternative Splicing GalleryENSG00000066651
Gene ExpressionTRMT11 [ NCBI-GEO ]   TRMT11 [ EBI - ARRAY_EXPRESS ]   TRMT11 [ SEEK ]   TRMT11 [ MEM ]
Gene Expression Viewer (FireBrowse)TRMT11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)60487
GTEX Portal (Tissue expression)TRMT11
Human Protein AtlasENSG00000066651-TRMT11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z4G4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z4G4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z4G4
Splice isoforms : SwissVarQ7Z4G4
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   
PhosPhoSitePlusQ7Z4G4
Domaine pattern : Prosite (Expaxy)N6_MTASE (PS00092)    SAM_MT_TRM11 (PS51627)   
Domains : Interpro (EBI)DNA_methylase_N6_adenine_CS    RNA_methylase_dom    SAM-dependent_MTases    tRNA_mtfrase_TRM11   
Domain families : Pfam (Sanger)UPF0020 (PF01170)   
Domain families : Pfam (NCBI)pfam01170   
Conserved Domain (NCBI)TRMT11
DMDM Disease mutations60487
Blocks (Seattle)TRMT11
SuperfamilyQ7Z4G4
Human Protein Atlas [tissue]ENSG00000066651-TRMT11 [tissue]
Peptide AtlasQ7Z4G4
HPRD12898
IPIIPI00470606   IPI00741576   IPI00644082   IPI00644613   IPI01013473   IPI01012198   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z4G4
IntAct (EBI)Q7Z4G4
FunCoupENSG00000066651
BioGRIDTRMT11
STRING (EMBL)TRMT11
ZODIACTRMT11
Ontologies - Pathways
QuickGOQ7Z4G4
Ontology : AmiGOtRNA binding  tRNA (guanine-N2-)-methyltransferase activity  tRNA methylation  
Ontology : EGO-EBItRNA binding  tRNA (guanine-N2-)-methyltransferase activity  tRNA methylation  
NDEx NetworkTRMT11
Atlas of Cancer Signalling NetworkTRMT11
Wikipedia pathwaysTRMT11
Orthology - Evolution
OrthoDB60487
GeneTree (enSembl)ENSG00000066651
Phylogenetic Trees/Animal Genes : TreeFamTRMT11
HOVERGENQ7Z4G4
HOGENOMQ7Z4G4
Homologs : HomoloGeneTRMT11
Homology/Alignments : Family Browser (UCSC)TRMT11
Gene fusions - Rearrangements
Fusion : MitelmanTPD52L1/TRMT11 [6q22.31/6q22.32]  [t(6;6)(q22;q22)]  
Fusion : MitelmanTRMT11/HINT3 [6q22.32/6q22.32]  [t(6;6)(q22;q22)]  
Fusion : MitelmanTRMT11/ICK [6q22.32/6p12.2]  [t(6;6)(p12;q22)]  
Fusion : MitelmanTRMT11/NCOA7 [6q22.32/6q22.32]  [t(6;6)(q22;q22)]  
Fusion : MitelmanTRMT11/RNF217 [6q22.32/6q22.31]  [t(6;6)(q22;q22)]  
Fusion : MitelmanTRMT11/SLC16A10 [6q22.32/6q21]  [t(6;6)(q21;q22)]  
Fusion PortalTRMT11 6q22.32 HINT3 6q22.32 HNSC LUAD
Fusion PortalTRMT11 6q22.32 ICK 6p12.2 BRCA
Fusion PortalTRMT11 6q22.32 NCOA7 6q22.32 LUAD
Fusion PortalTRMT11 6q22.32 RNF217 6q22.31 BRCA
Fusion PortalTRMT11 6q22.32 SLC16A10 6q21 LUAD
Fusion : QuiverTRMT11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRMT11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRMT11
dbVarTRMT11
ClinVarTRMT11
1000_GenomesTRMT11 
Exome Variant ServerTRMT11
ExAC (Exome Aggregation Consortium)ENSG00000066651
GNOMAD BrowserENSG00000066651
Varsome BrowserTRMT11
Genetic variants : HAPMAP60487
Genomic Variants (DGV)TRMT11 [DGVbeta]
DECIPHERTRMT11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRMT11 
Mutations
ICGC Data PortalTRMT11 
TCGA Data PortalTRMT11 
Broad Tumor PortalTRMT11
OASIS PortalTRMT11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRMT11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRMT11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRMT11
DgiDB (Drug Gene Interaction Database)TRMT11
DoCM (Curated mutations)TRMT11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRMT11 (select a term)
intoGenTRMT11
Cancer3DTRMT11(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTRMT11
MedgenTRMT11
Genetic Testing Registry TRMT11
NextProtQ7Z4G4 [Medical]
TSGene60487
GENETestsTRMT11
Target ValidationTRMT11
Huge Navigator TRMT11 [HugePedia]
snp3D : Map Gene to Disease60487
BioCentury BCIQTRMT11
ClinGenTRMT11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD60487
Chemical/Pharm GKB GenePA162407032
Clinical trialTRMT11
Miscellaneous
canSAR (ICR)TRMT11 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRMT11
EVEXTRMT11
GoPubMedTRMT11
iHOPTRMT11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:46:58 CET 2018

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