TRMT112 (tRNA methyltransferase activator subunit 11-2)

2014-11-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
HSPC152,HSPC170,TRM112,TRMT11-2,hTrm112
FUSION GENES

Other Information

Locus ID:

NCBI: 51504
MIM: 618630
HGNC: 26940
Ensembl: ENSG00000173113

Variants:

dbSNP: 51504
ClinVar: 51504
TCGA: ENSG00000173113
COSMIC: TRMT112

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173113ENST00000308774Q9UI30
ENSG00000173113ENST00000535126F5GZZ7
ENSG00000173113ENST00000535750F5GYQ2
ENSG00000173113ENST00000539854F5GX77
ENSG00000173113ENST00000544844Q9UI30
ENSG00000173113ENST00000544844A0A024R565

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation TerminationREACTOMER-HSA-72764
Gene ExpressionREACTOMER-HSA-74160
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
MethylationREACTOMER-HSA-156581
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315
rRNA processingREACTOMER-HSA-72312
rRNA modification in the nucleus and cytosolREACTOMER-HSA-6790901
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
258516042015The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.26
313282272019The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112.16
262141852015The Stability of Ribosome Biogenesis Factor WBSCR22 Is Regulated by Interaction with TRMT112 via Ubiquitin-Proteasome Pathway.8

Citation

Dessen P

TRMT112 (tRNA methyltransferase activator subunit 11-2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75196/trmt112