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TRMT12 (tRNA methyltransferase 12 homolog)

Identity

Alias (NCBI)TRM12
TYW2
HGNC (Hugo) TRMT12
HGNC Alias symbFLJ20772
Trm12
TYW2
HGNC Alias nametRNA-yW synthesizing protein 2
HGNC Previous nametRNA methyltranferase 12 homolog (S. cerevisiae)
 tRNA methyltransferase 12 homolog (S. cerevisiae)
LocusID (NCBI) 55039
Atlas_Id 46933
Location 8q24.13  [Link to chromosome band 8q24]
Location_base_pair Starts at 124450820 and ends at 124453025 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
WDR74 (11q12.3) / TRMT12 (8q24.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)TRMT12   26091
Cards
Entrez_Gene (NCBI)TRMT12    tRNA methyltransferase 12 homolog
AliasesTRM12; TYW2
GeneCards (Weizmann)TRMT12
Ensembl hg19 (Hinxton)ENSG00000183665 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183665 [Gene_View]  ENSG00000183665 [Sequence]  chr8:124450820-124453025 [Contig_View]  TRMT12 [Vega]
ICGC DataPortalENSG00000183665
TCGA cBioPortalTRMT12
AceView (NCBI)TRMT12
Genatlas (Paris)TRMT12
SOURCE (Princeton)TRMT12
Genetics Home Reference (NIH)TRMT12
Genomic and cartography
GoldenPath hg38 (UCSC)TRMT12  -     chr8:124450820-124453025 +  8q24.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRMT12  -     8q24.13   [Description]    (hg19-Feb_2009)
GoldenPathTRMT12 - 8q24.13 [CytoView hg19]  TRMT12 - 8q24.13 [CytoView hg38]
ImmunoBaseENSG00000183665
Genome Data Viewer NCBITRMT12 [Mapview hg19]  
OMIM611244   
Gene and transcription
Genbank (Entrez)AA608716 AK000779 AK222727 AK225083 BC003057
RefSeq transcript (Entrez)NM_017956
Consensus coding sequences : CCDS (NCBI)TRMT12
Gene ExpressionTRMT12 [ NCBI-GEO ]   TRMT12 [ EBI - ARRAY_EXPRESS ]   TRMT12 [ SEEK ]   TRMT12 [ MEM ]
Gene Expression Viewer (FireBrowse)TRMT12 [ Firebrowse - Broad ]
GenevisibleExpression of TRMT12 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55039
GTEX Portal (Tissue expression)TRMT12
Human Protein AtlasENSG00000183665-TRMT12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ53H54   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ53H54  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ53H54
Catalytic activity : Enzyme2.5.1.114 [ Enzyme-Expasy ]   2.5.1.1142.5.1.114 [ IntEnz-EBI ]   2.5.1.114 [ BRENDA ]   2.5.1.114 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ53H54
Domaine pattern : Prosite (Expaxy)SAM_MT_TRM5_TYW2 (PS51684)   
Domains : Interpro (EBI)MeTrfase_TRM5/TYW2    SAM-dependent_MTases   
Domain families : Pfam (Sanger)Met_10 (PF02475)   
Domain families : Pfam (NCBI)pfam02475   
Conserved Domain (NCBI)TRMT12
SuperfamilyQ53H54
AlphaFold pdb e-kbQ53H54   
Human Protein Atlas [tissue]ENSG00000183665-TRMT12 [tissue]
HPRD07947
Protein Interaction databases
DIP (DOE-UCLA)Q53H54
IntAct (EBI)Q53H54
BioGRIDTRMT12
STRING (EMBL)TRMT12
ZODIACTRMT12
Ontologies - Pathways
QuickGOQ53H54
Ontology : AmiGOprotein binding  cytoplasm  tRNA methyltransferase activity  tRNA methylation  tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity  
Ontology : EGO-EBIprotein binding  cytoplasm  tRNA methyltransferase activity  tRNA methylation  tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity  
NDEx NetworkTRMT12
Atlas of Cancer Signalling NetworkTRMT12
Wikipedia pathwaysTRMT12
Orthology - Evolution
OrthoDB55039
GeneTree (enSembl)ENSG00000183665
Phylogenetic Trees/Animal Genes : TreeFamTRMT12
Homologs : HomoloGeneTRMT12
Homology/Alignments : Family Browser (UCSC)TRMT12
Gene fusions - Rearrangements
Fusion : QuiverTRMT12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRMT12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRMT12
dbVarTRMT12
ClinVarTRMT12
MonarchTRMT12
1000_GenomesTRMT12 
Exome Variant ServerTRMT12
GNOMAD BrowserENSG00000183665
Varsome BrowserTRMT12
ACMGTRMT12 variants
VarityQ53H54
Genomic Variants (DGV)TRMT12 [DGVbeta]
DECIPHERTRMT12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRMT12 
Mutations
ICGC Data PortalTRMT12 
TCGA Data PortalTRMT12 
Broad Tumor PortalTRMT12
OASIS PortalTRMT12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRMT12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRMT12
Mutations and Diseases : HGMDTRMT12
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRMT12
DgiDB (Drug Gene Interaction Database)TRMT12
DoCM (Curated mutations)TRMT12
CIViC (Clinical Interpretations of Variants in Cancer)TRMT12
Cancer3DTRMT12
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611244   
Orphanet
DisGeNETTRMT12
MedgenTRMT12
Genetic Testing Registry TRMT12
NextProtQ53H54 [Medical]
GENETestsTRMT12
Target ValidationTRMT12
Huge Navigator TRMT12 [HugePedia]
ClinGenTRMT12
Clinical trials, drugs, therapy
MyCancerGenomeTRMT12
Protein Interactions : CTDTRMT12
Pharm GKB GenePA142670700
PharosQ53H54
Clinical trialTRMT12
Miscellaneous
canSAR (ICR)TRMT12
HarmonizomeTRMT12
DataMed IndexTRMT12
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRMT12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:28 CEST 2021
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