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TRMT2A (tRNA methyltransferase 2 homolog A)

Identity

Alias_namestRNA methyltransferase 2 homolog A (S. cerevisiae)
Alias_symbol (synonym)HTF9C
Other alias
HGNC (Hugo) TRMT2A
LocusID (NCBI) 27037
Atlas_Id 51549
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 20099389 and ends at 20104818 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SSRP1 (11q12.1) / TRMT2A (22q11.21)TRMT2A (22q11.21) / SRRM3 (7q11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRMT2A   24974
Cards
Entrez_Gene (NCBI)TRMT2A  27037  tRNA methyltransferase 2 homolog A
AliasesHTF9C
GeneCards (Weizmann)TRMT2A
Ensembl hg19 (Hinxton)ENSG00000099899 [Gene_View]  chr22:20099389-20104818 [Contig_View]  TRMT2A [Vega]
Ensembl hg38 (Hinxton)ENSG00000099899 [Gene_View]  chr22:20099389-20104818 [Contig_View]  TRMT2A [Vega]
ICGC DataPortalENSG00000099899
TCGA cBioPortalTRMT2A
AceView (NCBI)TRMT2A
Genatlas (Paris)TRMT2A
WikiGenes27037
SOURCE (Princeton)TRMT2A
Genetics Home Reference (NIH)TRMT2A
Genomic and cartography
GoldenPath hg19 (UCSC)TRMT2A  -     chr22:20099389-20104818 -  22q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TRMT2A  -     22q11.21   [Description]    (hg38-Dec_2013)
EnsemblTRMT2A - 22q11.21 [CytoView hg19]  TRMT2A - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBITRMT2A [Mapview hg19]  TRMT2A [Mapview hg38]
OMIM611151   
Gene and transcription
Genbank (Entrez)AI539558 AK025106 AK057029 AK304068 BC013352
RefSeq transcript (Entrez)NM_001257994 NM_022727 NM_182984
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_011520 NW_004929429
Consensus coding sequences : CCDS (NCBI)TRMT2A
Cluster EST : UnigeneHs.713579 [ NCBI ]
CGAP (NCI)Hs.713579
Alternative Splicing GalleryENSG00000099899
Gene ExpressionTRMT2A [ NCBI-GEO ]   TRMT2A [ EBI - ARRAY_EXPRESS ]   TRMT2A [ SEEK ]   TRMT2A [ MEM ]
Gene Expression Viewer (FireBrowse)TRMT2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27037
GTEX Portal (Tissue expression)TRMT2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IZ69   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IZ69  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IZ69
Splice isoforms : SwissVarQ8IZ69
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   
PhosPhoSitePlusQ8IZ69
Domaine pattern : Prosite (Expaxy)RRM (PS50102)    SAM_MT_RNA_M5U (PS51687)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom    SAM-dependent_MTases    U5_MeTrfase_fam   
Domain families : Pfam (Sanger)tRNA_U5-meth_tr (PF05958)   
Domain families : Pfam (NCBI)pfam05958   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)TRMT2A
DMDM Disease mutations27037
Blocks (Seattle)TRMT2A
SuperfamilyQ8IZ69
Human Protein AtlasENSG00000099899
Peptide AtlasQ8IZ69
HPRD13719
IPIIPI00337307   IPI00472176   IPI00879451   IPI00878912   IPI01026181   IPI00879630   IPI00880137   
Protein Interaction databases
DIP (DOE-UCLA)Q8IZ69
IntAct (EBI)Q8IZ69
FunCoupENSG00000099899
BioGRIDTRMT2A
STRING (EMBL)TRMT2A
ZODIACTRMT2A
Ontologies - Pathways
QuickGOQ8IZ69
Ontology : AmiGOnucleotide binding  RNA methylation  RNA processing  RNA methyltransferase activity  poly(A) RNA binding  
Ontology : EGO-EBInucleotide binding  RNA methylation  RNA processing  RNA methyltransferase activity  poly(A) RNA binding  
NDEx NetworkTRMT2A
Atlas of Cancer Signalling NetworkTRMT2A
Wikipedia pathwaysTRMT2A
Orthology - Evolution
OrthoDB27037
GeneTree (enSembl)ENSG00000099899
Phylogenetic Trees/Animal Genes : TreeFamTRMT2A
HOVERGENQ8IZ69
HOGENOMQ8IZ69
Homologs : HomoloGeneTRMT2A
Homology/Alignments : Family Browser (UCSC)TRMT2A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRMT2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRMT2A
dbVarTRMT2A
ClinVarTRMT2A
1000_GenomesTRMT2A 
Exome Variant ServerTRMT2A
ExAC (Exome Aggregation Consortium)TRMT2A (select the gene name)
Genetic variants : HAPMAP27037
Genomic Variants (DGV)TRMT2A [DGVbeta]
DECIPHER (Syndromes)22:20099389-20104818  ENSG00000099899
CONAN: Copy Number AnalysisTRMT2A 
Mutations
ICGC Data PortalTRMT2A 
TCGA Data PortalTRMT2A 
Broad Tumor PortalTRMT2A
OASIS PortalTRMT2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRMT2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRMT2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRMT2A
DgiDB (Drug Gene Interaction Database)TRMT2A
DoCM (Curated mutations)TRMT2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRMT2A (select a term)
intoGenTRMT2A
Cancer3DTRMT2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611151   
Orphanet
MedgenTRMT2A
Genetic Testing Registry TRMT2A
NextProtQ8IZ69 [Medical]
TSGene27037
GENETestsTRMT2A
Huge Navigator TRMT2A [HugePedia]
snp3D : Map Gene to Disease27037
BioCentury BCIQTRMT2A
ClinGenTRMT2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27037
Chemical/Pharm GKB GenePA164726751
Clinical trialTRMT2A
Miscellaneous
canSAR (ICR)TRMT2A (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRMT2A
EVEXTRMT2A
GoPubMedTRMT2A
iHOPTRMT2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:32:26 CET 2017

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