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TRMT2B (tRNA methyltransferase 2 homolog B)

Identity

Alias_namesCXorf34
chromosome X open reading frame 34
tRNA methyltransferase 2 homolog B (S. cerevisiae)
Alias_symbol (synonym)FLJ12687
Other aliasdJ341D10.3
HGNC (Hugo) TRMT2B
LocusID (NCBI) 79979
Atlas_Id 54725
Location Xq22.1  [Link to chromosome band Xq22]
Location_base_pair Starts at 101009345 and ends at 101052116 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARL13A (Xq22.1) / TRMT2B (Xq22.1)TRMT2B (Xq22.1) / TNFRSF12A (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRMT2B   25748
Cards
Entrez_Gene (NCBI)TRMT2B  79979  tRNA methyltransferase 2 homolog B
AliasesCXorf34; dJ341D10.3
GeneCards (Weizmann)TRMT2B
Ensembl hg19 (Hinxton)ENSG00000188917 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188917 [Gene_View]  chrX:101009345-101052116 [Contig_View]  TRMT2B [Vega]
ICGC DataPortalENSG00000188917
TCGA cBioPortalTRMT2B
AceView (NCBI)TRMT2B
Genatlas (Paris)TRMT2B
WikiGenes79979
SOURCE (Princeton)TRMT2B
Genetics Home Reference (NIH)TRMT2B
Genomic and cartography
GoldenPath hg38 (UCSC)TRMT2B  -     chrX:101009345-101052116 -  Xq22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRMT2B  -     Xq22.1   [Description]    (hg19-Feb_2009)
EnsemblTRMT2B - Xq22.1 [CytoView hg19]  TRMT2B - Xq22.1 [CytoView hg38]
Mapping of homologs : NCBITRMT2B [Mapview hg19]  TRMT2B [Mapview hg38]
Gene and transcription
Genbank (Entrez)AI222705 AK022749 AK315780 AL832849 BC007526
RefSeq transcript (Entrez)NM_001167970 NM_001167971 NM_001167972 NM_024917
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRMT2B
Cluster EST : UnigeneHs.496501 [ NCBI ]
CGAP (NCI)Hs.496501
Alternative Splicing GalleryENSG00000188917
Gene ExpressionTRMT2B [ NCBI-GEO ]   TRMT2B [ EBI - ARRAY_EXPRESS ]   TRMT2B [ SEEK ]   TRMT2B [ MEM ]
Gene Expression Viewer (FireBrowse)TRMT2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79979
GTEX Portal (Tissue expression)TRMT2B
Human Protein AtlasENSG00000188917-TRMT2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96GJ1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96GJ1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96GJ1
Splice isoforms : SwissVarQ96GJ1
Catalytic activity : Enzyme2.1.1.35 [ Enzyme-Expasy ]   2.1.1.352.1.1.35 [ IntEnz-EBI ]   2.1.1.35 [ BRENDA ]   2.1.1.35 [ KEGG ]   
PhosPhoSitePlusQ96GJ1
Domaine pattern : Prosite (Expaxy)SAM_MT_RNA_M5U (PS51687)   
Domains : Interpro (EBI)SAM-dependent_MTases    tRNA_(uracil-5-)_MeTrfase_met    U5_MeTrfase_fam   
Domain families : Pfam (Sanger)tRNA_U5-meth_tr (PF05958)   
Domain families : Pfam (NCBI)pfam05958   
Conserved Domain (NCBI)TRMT2B
DMDM Disease mutations79979
Blocks (Seattle)TRMT2B
SuperfamilyQ96GJ1
Human Protein Atlas [tissue]ENSG00000188917-TRMT2B [tissue]
Peptide AtlasQ96GJ1
HPRD06520
IPIIPI00747797   IPI00550091   IPI00749054   
Protein Interaction databases
DIP (DOE-UCLA)Q96GJ1
IntAct (EBI)Q96GJ1
FunCoupENSG00000188917
BioGRIDTRMT2B
STRING (EMBL)TRMT2B
ZODIACTRMT2B
Ontologies - Pathways
QuickGOQ96GJ1
Ontology : AmiGORNA methylation  protein binding  mitochondrion  tRNA processing  S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity  
Ontology : EGO-EBIRNA methylation  protein binding  mitochondrion  tRNA processing  S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity  
NDEx NetworkTRMT2B
Atlas of Cancer Signalling NetworkTRMT2B
Wikipedia pathwaysTRMT2B
Orthology - Evolution
OrthoDB79979
GeneTree (enSembl)ENSG00000188917
Phylogenetic Trees/Animal Genes : TreeFamTRMT2B
HOVERGENQ96GJ1
HOGENOMQ96GJ1
Homologs : HomoloGeneTRMT2B
Homology/Alignments : Family Browser (UCSC)TRMT2B
Gene fusions - Rearrangements
Fusion : MitelmanARL13A/TRMT2B [Xq22.1/Xq22.1]  [t(X;X)(q22;q22)]  
Tumor Fusion PortalTRMT2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRMT2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRMT2B
dbVarTRMT2B
ClinVarTRMT2B
1000_GenomesTRMT2B 
Exome Variant ServerTRMT2B
ExAC (Exome Aggregation Consortium)ENSG00000188917
GNOMAD BrowserENSG00000188917
Genetic variants : HAPMAP79979
Genomic Variants (DGV)TRMT2B [DGVbeta]
DECIPHERTRMT2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRMT2B 
Mutations
ICGC Data PortalTRMT2B 
TCGA Data PortalTRMT2B 
Broad Tumor PortalTRMT2B
OASIS PortalTRMT2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRMT2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRMT2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch TRMT2B
DgiDB (Drug Gene Interaction Database)TRMT2B
DoCM (Curated mutations)TRMT2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRMT2B (select a term)
intoGenTRMT2B
Cancer3DTRMT2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTRMT2B
MedgenTRMT2B
Genetic Testing Registry TRMT2B
NextProtQ96GJ1 [Medical]
TSGene79979
GENETestsTRMT2B
Target ValidationTRMT2B
Huge Navigator TRMT2B [HugePedia]
snp3D : Map Gene to Disease79979
BioCentury BCIQTRMT2B
ClinGenTRMT2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79979
Chemical/Pharm GKB GenePA164726782
Clinical trialTRMT2B
Miscellaneous
canSAR (ICR)TRMT2B (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRMT2B
EVEXTRMT2B
GoPubMedTRMT2B
iHOPTRMT2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:39:51 CET 2017

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