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TRMT2B (tRNA methyltransferase 2 homolog B)

Identity

Alias (NCBI)CXorf34
dJ341D10.3
HGNC (Hugo) TRMT2B
HGNC Alias symbFLJ12687
HGNC Previous nameCXorf34
HGNC Previous namechromosome X open reading frame 34
 tRNA methyltransferase 2 homolog B (S. cerevisiae)
LocusID (NCBI) 79979
Atlas_Id 54725
Location Xq22.1  [Link to chromosome band Xq22]
Location_base_pair Starts at 101009350 and ends at 101052111 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARL13A (Xq22.1) / TRMT2B (Xq22.1)TRMT2B (Xq22.1) / TNFRSF12A (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(X;X)(q22;q22) ARL13A/TRMT2B


External links

 

Nomenclature
HGNC (Hugo)TRMT2B   25748
Cards
Entrez_Gene (NCBI)TRMT2B    tRNA methyltransferase 2 homolog B
AliasesCXorf34; dJ341D10.3
GeneCards (Weizmann)TRMT2B
Ensembl hg19 (Hinxton)ENSG00000188917 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188917 [Gene_View]  ENSG00000188917 [Sequence]  chrX:101009350-101052111 [Contig_View]  TRMT2B [Vega]
ICGC DataPortalENSG00000188917
TCGA cBioPortalTRMT2B
AceView (NCBI)TRMT2B
Genatlas (Paris)TRMT2B
SOURCE (Princeton)TRMT2B
Genetics Home Reference (NIH)TRMT2B
Genomic and cartography
GoldenPath hg38 (UCSC)TRMT2B  -     chrX:101009350-101052111 -  Xq22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRMT2B  -     Xq22.1   [Description]    (hg19-Feb_2009)
GoldenPathTRMT2B - Xq22.1 [CytoView hg19]  TRMT2B - Xq22.1 [CytoView hg38]
ImmunoBaseENSG00000188917
Genome Data Viewer NCBITRMT2B [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AI222705 AK022749 AK315780 AL832849 BC007526
RefSeq transcript (Entrez)NM_001167970 NM_001167971 NM_001167972 NM_024917
Consensus coding sequences : CCDS (NCBI)TRMT2B
Gene ExpressionTRMT2B [ NCBI-GEO ]   TRMT2B [ EBI - ARRAY_EXPRESS ]   TRMT2B [ SEEK ]   TRMT2B [ MEM ]
Gene Expression Viewer (FireBrowse)TRMT2B [ Firebrowse - Broad ]
GenevisibleExpression of TRMT2B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79979
GTEX Portal (Tissue expression)TRMT2B
Human Protein AtlasENSG00000188917-TRMT2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96GJ1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96GJ1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96GJ1
Catalytic activity : Enzyme2.1.1.35 [ Enzyme-Expasy ]   2.1.1.352.1.1.35 [ IntEnz-EBI ]   2.1.1.35 [ BRENDA ]   2.1.1.35 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ96GJ1
Domaine pattern : Prosite (Expaxy)SAM_MT_RNA_M5U (PS51687)   
Domains : Interpro (EBI)SAM-dependent_MTases    tRNA_(uracil-5-)_MeTrfase_met    U5_MeTrfase_fam   
Domain families : Pfam (Sanger)tRNA_U5-meth_tr (PF05958)   
Domain families : Pfam (NCBI)pfam05958   
Conserved Domain (NCBI)TRMT2B
SuperfamilyQ96GJ1
AlphaFold pdb e-kbQ96GJ1   
Human Protein Atlas [tissue]ENSG00000188917-TRMT2B [tissue]
HPRD06520
Protein Interaction databases
DIP (DOE-UCLA)Q96GJ1
IntAct (EBI)Q96GJ1
BioGRIDTRMT2B
STRING (EMBL)TRMT2B
ZODIACTRMT2B
Ontologies - Pathways
QuickGOQ96GJ1
Ontology : AmiGOprotein binding  tRNA methylation  S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity  
Ontology : EGO-EBIprotein binding  tRNA methylation  S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity  
NDEx NetworkTRMT2B
Atlas of Cancer Signalling NetworkTRMT2B
Wikipedia pathwaysTRMT2B
Orthology - Evolution
OrthoDB79979
GeneTree (enSembl)ENSG00000188917
Phylogenetic Trees/Animal Genes : TreeFamTRMT2B
Homologs : HomoloGeneTRMT2B
Homology/Alignments : Family Browser (UCSC)TRMT2B
Gene fusions - Rearrangements
Fusion : MitelmanARL13A/TRMT2B [Xq22.1/Xq22.1]  
Fusion : QuiverTRMT2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRMT2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRMT2B
dbVarTRMT2B
ClinVarTRMT2B
MonarchTRMT2B
1000_GenomesTRMT2B 
Exome Variant ServerTRMT2B
GNOMAD BrowserENSG00000188917
Varsome BrowserTRMT2B
ACMGTRMT2B variants
VarityQ96GJ1
Genomic Variants (DGV)TRMT2B [DGVbeta]
DECIPHERTRMT2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRMT2B 
Mutations
ICGC Data PortalTRMT2B 
TCGA Data PortalTRMT2B 
Broad Tumor PortalTRMT2B
OASIS PortalTRMT2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRMT2B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRMT2B
Mutations and Diseases : HGMDTRMT2B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRMT2B
DgiDB (Drug Gene Interaction Database)TRMT2B
DoCM (Curated mutations)TRMT2B
CIViC (Clinical Interpretations of Variants in Cancer)TRMT2B
Cancer3DTRMT2B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTRMT2B
MedgenTRMT2B
Genetic Testing Registry TRMT2B
NextProtQ96GJ1 [Medical]
GENETestsTRMT2B
Target ValidationTRMT2B
Huge Navigator TRMT2B [HugePedia]
ClinGenTRMT2B
Clinical trials, drugs, therapy
MyCancerGenomeTRMT2B
Protein Interactions : CTDTRMT2B
Pharm GKB GenePA164726782
PharosQ96GJ1
Clinical trialTRMT2B
Miscellaneous
canSAR (ICR)TRMT2B
HarmonizomeTRMT2B
DataMed IndexTRMT2B
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRMT2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:36:28 CEST 2021

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