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TRMU (tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase)

Identity

Alias_namesTRMT
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
Alias_symbol (synonym)FLJ10140
MTO2
Other aliasMTU1
TRMT1
TRNT1
HGNC (Hugo) TRMU
LocusID (NCBI) 55687
Atlas_Id 75203
Location 22q13.31  [Link to chromosome band 22q13]
Location_base_pair Starts at 46731298 and ends at 46753237 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TRMU (22q13.31) / LYL1 (19p13.2)TRMU (22q13.31) / NSMCE2 (8q24.13)TRMU (22q13.31) / TTC38 (22q13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRMU   25481
Cards
Entrez_Gene (NCBI)TRMU  55687  tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
AliasesMTO2; MTU1; TRMT; TRMT1; 
TRNT1
GeneCards (Weizmann)TRMU
Ensembl hg19 (Hinxton)ENSG00000100416 [Gene_View]  chr22:46731298-46753237 [Contig_View]  TRMU [Vega]
Ensembl hg38 (Hinxton)ENSG00000100416 [Gene_View]  chr22:46731298-46753237 [Contig_View]  TRMU [Vega]
ICGC DataPortalENSG00000100416
TCGA cBioPortalTRMU
AceView (NCBI)TRMU
Genatlas (Paris)TRMU
WikiGenes55687
SOURCE (Princeton)TRMU
Genetics Home Reference (NIH)TRMU
Genomic and cartography
GoldenPath hg19 (UCSC)TRMU  -     chr22:46731298-46753237 +  22q13.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TRMU  -     22q13.31   [Description]    (hg38-Dec_2013)
EnsemblTRMU - 22q13.31 [CytoView hg19]  TRMU - 22q13.31 [CytoView hg38]
Mapping of homologs : NCBITRMU [Mapview hg19]  TRMU [Mapview hg38]
OMIM580000   580000   610230   613070   
Gene and transcription
Genbank (Entrez)AB178028 AK000212 AK001002 AK055295 AK093743
RefSeq transcript (Entrez)NM_001008569 NM_001008571 NM_001282782 NM_001282783 NM_001282784 NM_001282785 NM_018006
RefSeq genomic (Entrez)NC_000022 NC_018933 NG_012173 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)TRMU
Cluster EST : UnigeneHs.439524 [ NCBI ]
CGAP (NCI)Hs.439524
Alternative Splicing GalleryENSG00000100416
Gene ExpressionTRMU [ NCBI-GEO ]   TRMU [ EBI - ARRAY_EXPRESS ]   TRMU [ SEEK ]   TRMU [ MEM ]
Gene Expression Viewer (FireBrowse)TRMU [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55687
GTEX Portal (Tissue expression)TRMU
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75648   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75648  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75648
Splice isoforms : SwissVarO75648
Catalytic activity : Enzyme2.8.1.- [ Enzyme-Expasy ]   2.8.1.-2.8.1.- [ IntEnz-EBI ]   2.8.1.- [ BRENDA ]   2.8.1.- [ KEGG ]   
PhosPhoSitePlusO75648
Domains : Interpro (EBI)Adenine_a_hdrlase_dom    Rossmann-like_a/b/a_fold    tRNA-specific_2-thiouridylase   
Domain families : Pfam (Sanger)tRNA_Me_trans (PF03054)   
Domain families : Pfam (NCBI)pfam03054   
Conserved Domain (NCBI)TRMU
DMDM Disease mutations55687
Blocks (Seattle)TRMU
SuperfamilyO75648
Human Protein AtlasENSG00000100416
Peptide AtlasO75648
HPRD15571
IPIIPI00026555   IPI00514782   IPI00903061   IPI00807637   IPI00909385   IPI00515029   
Protein Interaction databases
DIP (DOE-UCLA)O75648
IntAct (EBI)O75648
FunCoupENSG00000100416
BioGRIDTRMU
STRING (EMBL)TRMU
ZODIACTRMU
Ontologies - Pathways
QuickGOO75648
Ontology : AmiGOtRNA binding  tRNA wobble position uridine thiolation  tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity  ATP binding  mitochondrion  sulfurtransferase activity  tRNA methylation  
Ontology : EGO-EBItRNA binding  tRNA wobble position uridine thiolation  tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity  ATP binding  mitochondrion  sulfurtransferase activity  tRNA methylation  
Pathways : KEGGSulfur relay system   
NDEx NetworkTRMU
Atlas of Cancer Signalling NetworkTRMU
Wikipedia pathwaysTRMU
Orthology - Evolution
OrthoDB55687
GeneTree (enSembl)ENSG00000100416
Phylogenetic Trees/Animal Genes : TreeFamTRMU
HOVERGENO75648
HOGENOMO75648
Homologs : HomoloGeneTRMU
Homology/Alignments : Family Browser (UCSC)TRMU
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRMU [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRMU
dbVarTRMU
ClinVarTRMU
1000_GenomesTRMU 
Exome Variant ServerTRMU
ExAC (Exome Aggregation Consortium)TRMU (select the gene name)
Genetic variants : HAPMAP55687
Genomic Variants (DGV)TRMU [DGVbeta]
DECIPHER (Syndromes)22:46731298-46753237  ENSG00000100416
CONAN: Copy Number AnalysisTRMU 
Mutations
ICGC Data PortalTRMU 
TCGA Data PortalTRMU 
Broad Tumor PortalTRMU
OASIS PortalTRMU [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRMU  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRMU
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TRMU
DgiDB (Drug Gene Interaction Database)TRMU
DoCM (Curated mutations)TRMU (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRMU (select a term)
intoGenTRMU
Cancer3DTRMU(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM580000    580000    610230    613070   
Orphanet17783    19791    18849    12050   
MedgenTRMU
Genetic Testing Registry TRMU
NextProtO75648 [Medical]
TSGene55687
GENETestsTRMU
Huge Navigator TRMU [HugePedia]
snp3D : Map Gene to Disease55687
BioCentury BCIQTRMU
ClinGenTRMU
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55687
Chemical/Pharm GKB GenePA142670701
Clinical trialTRMU
Miscellaneous
canSAR (ICR)TRMU (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRMU
EVEXTRMU
GoPubMedTRMU
iHOPTRMU
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:49:52 CET 2017

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