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TRMU (tRNA mitochondrial 2-thiouridylase)

Identity

Alias (NCBI)LCAL3
MTO2
MTU1
TRMT
TRMT1
HGNC (Hugo) TRMU
HGNC Alias symbFLJ10140
MTO2
HGNC Previous nameTRMT
HGNC Previous nametRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
LocusID (NCBI) 55687
Atlas_Id 75203
Location 22q13.31  [Link to chromosome band 22q13]
Location_base_pair Starts at 46335714 and ends at 46357340 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRMU (22q13.31) / LYL1 (19p13.2)TRMU (22q13.31) / NSMCE2 (8q24.13)TRMU (22q13.31) / TTC38 (22q13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TRMU   25481
Cards
Entrez_Gene (NCBI)TRMU    tRNA mitochondrial 2-thiouridylase
AliasesLCAL3; MTO2; MTU1; TRMT; 
TRMT1
GeneCards (Weizmann)TRMU
Ensembl hg19 (Hinxton)ENSG00000100416 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100416 [Gene_View]  ENSG00000100416 [Sequence]  chr22:46335714-46357340 [Contig_View]  TRMU [Vega]
ICGC DataPortalENSG00000100416
TCGA cBioPortalTRMU
AceView (NCBI)TRMU
Genatlas (Paris)TRMU
SOURCE (Princeton)TRMU
Genetics Home Reference (NIH)TRMU
Genomic and cartography
GoldenPath hg38 (UCSC)TRMU  -     chr22:46335714-46357340 +  22q13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRMU  -     22q13.31   [Description]    (hg19-Feb_2009)
GoldenPathTRMU - 22q13.31 [CytoView hg19]  TRMU - 22q13.31 [CytoView hg38]
ImmunoBaseENSG00000100416
Genome Data Viewer NCBITRMU [Mapview hg19]  
OMIM580000   580000   610230   613070   
Gene and transcription
Genbank (Entrez)AB178028 AK000212 AK001002 AK055295 AK093743
RefSeq transcript (Entrez)NM_001008569 NM_001008571 NM_001282782 NM_001282783 NM_001282784 NM_001282785 NM_018006
Consensus coding sequences : CCDS (NCBI)TRMU
Gene ExpressionTRMU [ NCBI-GEO ]   TRMU [ EBI - ARRAY_EXPRESS ]   TRMU [ SEEK ]   TRMU [ MEM ]
Gene Expression Viewer (FireBrowse)TRMU [ Firebrowse - Broad ]
GenevisibleExpression of TRMU in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55687
GTEX Portal (Tissue expression)TRMU
Human Protein AtlasENSG00000100416-TRMU [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75648   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75648  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75648
PhosPhoSitePlusO75648
Domains : Interpro (EBI)Adenine_a_hdrlase_dom    Rossmann-like_a/b/a_fold    tRNA-specific_2-thiouridylase   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TRMU
SuperfamilyO75648
AlphaFold pdb e-kbO75648   
Human Protein Atlas [tissue]ENSG00000100416-TRMU [tissue]
HPRD15571
Protein Interaction databases
DIP (DOE-UCLA)O75648
IntAct (EBI)O75648
BioGRIDTRMU
STRING (EMBL)TRMU
ZODIACTRMU
Ontologies - Pathways
QuickGOO75648
Ontology : AmiGOtRNA binding  tRNA wobble position uridine thiolation  ATP binding  mitochondrion  mitochondrion  mitochondrion  tRNA-5-taurinomethyluridine 2-sulfurtransferase  
Ontology : EGO-EBItRNA binding  tRNA wobble position uridine thiolation  ATP binding  mitochondrion  mitochondrion  mitochondrion  tRNA-5-taurinomethyluridine 2-sulfurtransferase  
NDEx NetworkTRMU
Atlas of Cancer Signalling NetworkTRMU
Wikipedia pathwaysTRMU
Orthology - Evolution
OrthoDB55687
GeneTree (enSembl)ENSG00000100416
Phylogenetic Trees/Animal Genes : TreeFamTRMU
Homologs : HomoloGeneTRMU
Homology/Alignments : Family Browser (UCSC)TRMU
Gene fusions - Rearrangements
Fusion : QuiverTRMU
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRMU [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRMU
dbVarTRMU
ClinVarTRMU
MonarchTRMU
1000_GenomesTRMU 
Exome Variant ServerTRMU
GNOMAD BrowserENSG00000100416
Varsome BrowserTRMU
ACMGTRMU variants
VarityO75648
Genomic Variants (DGV)TRMU [DGVbeta]
DECIPHERTRMU [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRMU 
Mutations
ICGC Data PortalTRMU 
TCGA Data PortalTRMU 
Broad Tumor PortalTRMU
OASIS PortalTRMU [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRMU  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRMU
Mutations and Diseases : HGMDTRMU
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRMU
DgiDB (Drug Gene Interaction Database)TRMU
DoCM (Curated mutations)TRMU
CIViC (Clinical Interpretations of Variants in Cancer)TRMU
Cancer3DTRMU
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM580000    580000    610230    613070   
Orphanet17783    19791    18849    12050   
DisGeNETTRMU
MedgenTRMU
Genetic Testing Registry TRMU
NextProtO75648 [Medical]
GENETestsTRMU
Target ValidationTRMU
Huge Navigator TRMU [HugePedia]
ClinGenTRMU
Clinical trials, drugs, therapy
MyCancerGenomeTRMU
Protein Interactions : CTDTRMU
Pharm GKB GenePA142670701
PharosO75648
Clinical trialTRMU
Miscellaneous
canSAR (ICR)TRMU
HarmonizomeTRMU
DataMed IndexTRMU
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRMU
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:27:04 CEST 2021

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