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TRPC1 (transient receptor potential cation channel subfamily C member 1)

Identity

Alias (NCBI)HTRP-1
TRP1
HGNC (Hugo) TRPC1
HGNC Alias symbHTRP-1
HGNC Previous nametransient receptor potential cation channel, subfamily C, member 1
LocusID (NCBI) 7220
Atlas_Id 43870
Location 3q23  [Link to chromosome band 3q23]
Location_base_pair Starts at 142724424 and ends at 142807887 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRPC1 (3q23) / PTPRG (3p14.2)TRPC1 3q23 / PTPRG 3p14.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TRPC1   12333
Cards
Entrez_Gene (NCBI)TRPC1    transient receptor potential cation channel subfamily C member 1
AliasesHTRP-1; TRP1
GeneCards (Weizmann)TRPC1
Ensembl hg19 (Hinxton)ENSG00000144935 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144935 [Gene_View]  ENSG00000144935 [Sequence]  chr3:142724424-142807887 [Contig_View]  TRPC1 [Vega]
ICGC DataPortalENSG00000144935
TCGA cBioPortalTRPC1
AceView (NCBI)TRPC1
Genatlas (Paris)TRPC1
SOURCE (Princeton)TRPC1
Genetics Home Reference (NIH)TRPC1
Genomic and cartography
GoldenPath hg38 (UCSC)TRPC1  -     chr3:142724424-142807887 +  3q23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRPC1  -     3q23   [Description]    (hg19-Feb_2009)
GoldenPathTRPC1 - 3q23 [CytoView hg19]  TRPC1 - 3q23 [CytoView hg38]
ImmunoBaseENSG00000144935
Genome Data Viewer NCBITRPC1 [Mapview hg19]  
OMIM602343   
Gene and transcription
Genbank (Entrez)AB255425 AF483645 AI280444 BC112338 BC113953
RefSeq transcript (Entrez)NM_001251845 NM_003304
Consensus coding sequences : CCDS (NCBI)TRPC1
Gene ExpressionTRPC1 [ NCBI-GEO ]   TRPC1 [ EBI - ARRAY_EXPRESS ]   TRPC1 [ SEEK ]   TRPC1 [ MEM ]
Gene Expression Viewer (FireBrowse)TRPC1 [ Firebrowse - Broad ]
GenevisibleExpression of TRPC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7220
GTEX Portal (Tissue expression)TRPC1
Human Protein AtlasENSG00000144935-TRPC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48995   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48995  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48995
PhosPhoSitePlusP48995
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_sf    Ion_trans_dom    TRP_dom    TRPC1_channel    TRPC_channel   
Domain families : Pfam (Sanger)Ion_trans (PF00520)    TRP_2 (PF08344)   
Domain families : Pfam (NCBI)pfam00520    pfam08344   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)TRPC1
SuperfamilyP48995
AlphaFold pdb e-kbP48995   
Human Protein Atlas [tissue]ENSG00000144935-TRPC1 [tissue]
HPRD11894
Protein Interaction databases
DIP (DOE-UCLA)P48995
IntAct (EBI)P48995
BioGRIDTRPC1
STRING (EMBL)TRPC1
ZODIACTRPC1
Ontologies - Pathways
QuickGOP48995
Ontology : AmiGOsignaling receptor binding  cation channel activity  calcium channel activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  calcium ion transport  manganese ion transport  store-operated calcium channel activity  cation channel complex  melanin biosynthetic process  receptor complex  ATPase binding  positive regulation of release of sequestered calcium ion into cytosol  regulation of cytosolic calcium ion concentration  regulation of cytosolic calcium ion concentration  response to calcium ion  calcium ion transmembrane transport  calcium ion transmembrane transport  inositol 1,4,5 trisphosphate binding  inositol 1,4,5 trisphosphate binding  regulation of cardiac conduction  
Ontology : EGO-EBIsignaling receptor binding  cation channel activity  calcium channel activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  calcium ion transport  manganese ion transport  store-operated calcium channel activity  cation channel complex  melanin biosynthetic process  receptor complex  ATPase binding  positive regulation of release of sequestered calcium ion into cytosol  regulation of cytosolic calcium ion concentration  regulation of cytosolic calcium ion concentration  response to calcium ion  calcium ion transmembrane transport  calcium ion transmembrane transport  inositol 1,4,5 trisphosphate binding  inositol 1,4,5 trisphosphate binding  regulation of cardiac conduction  
Pathways : KEGGGlutamatergic synapse    Serotonergic synapse    Pancreatic secretion   
NDEx NetworkTRPC1
Atlas of Cancer Signalling NetworkTRPC1
Wikipedia pathwaysTRPC1
Orthology - Evolution
OrthoDB7220
GeneTree (enSembl)ENSG00000144935
Phylogenetic Trees/Animal Genes : TreeFamTRPC1
Homologs : HomoloGeneTRPC1
Homology/Alignments : Family Browser (UCSC)TRPC1
Gene fusions - Rearrangements
Fusion : MitelmanTRPC1/PTPRG [3q23/3p14.2]  
Fusion : QuiverTRPC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRPC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRPC1
dbVarTRPC1
ClinVarTRPC1
MonarchTRPC1
1000_GenomesTRPC1 
Exome Variant ServerTRPC1
GNOMAD BrowserENSG00000144935
Varsome BrowserTRPC1
ACMGTRPC1 variants
VarityP48995
Genomic Variants (DGV)TRPC1 [DGVbeta]
DECIPHERTRPC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRPC1 
Mutations
ICGC Data PortalTRPC1 
TCGA Data PortalTRPC1 
Broad Tumor PortalTRPC1
OASIS PortalTRPC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRPC1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRPC1
Mutations and Diseases : HGMDTRPC1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRPC1
DgiDB (Drug Gene Interaction Database)TRPC1
DoCM (Curated mutations)TRPC1
CIViC (Clinical Interpretations of Variants in Cancer)TRPC1
Cancer3DTRPC1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602343   
Orphanet
DisGeNETTRPC1
MedgenTRPC1
Genetic Testing Registry TRPC1
NextProtP48995 [Medical]
GENETestsTRPC1
Target ValidationTRPC1
Huge Navigator TRPC1 [HugePedia]
ClinGenTRPC1
Clinical trials, drugs, therapy
MyCancerGenomeTRPC1
Protein Interactions : CTDTRPC1
Pharm GKB GenePA357
PharosP48995
Clinical trialTRPC1
Miscellaneous
canSAR (ICR)TRPC1
HarmonizomeTRPC1
DataMed IndexTRPC1
Probes
Litterature
PubMed183 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRPC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:30 CEST 2021

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