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TRPC3 (transient receptor potential cation channel subfamily C member 3)

Identity

Alias_namestransient receptor potential cation channel
Other aliasSCA41
TRP3
HGNC (Hugo) TRPC3
LocusID (NCBI) 7222
Atlas_Id 50070
Location 4q27  [Link to chromosome band 4q27]
Location_base_pair Starts at 121879028 and ends at 121951754 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NDST4 (4q26) / TRPC3 (4q27)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRPC3   12335
Cards
Entrez_Gene (NCBI)TRPC3  7222  transient receptor potential cation channel subfamily C member 3
AliasesSCA41; TRP3
GeneCards (Weizmann)TRPC3
Ensembl hg19 (Hinxton)ENSG00000138741 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138741 [Gene_View]  chr4:121879028-121951754 [Contig_View]  TRPC3 [Vega]
ICGC DataPortalENSG00000138741
TCGA cBioPortalTRPC3
AceView (NCBI)TRPC3
Genatlas (Paris)TRPC3
WikiGenes7222
SOURCE (Princeton)TRPC3
Genetics Home Reference (NIH)TRPC3
Genomic and cartography
GoldenPath hg38 (UCSC)TRPC3  -     chr4:121879028-121951754 -  4q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRPC3  -     4q27   [Description]    (hg19-Feb_2009)
EnsemblTRPC3 - 4q27 [CytoView hg19]  TRPC3 - 4q27 [CytoView hg38]
Mapping of homologs : NCBITRPC3 [Mapview hg19]  TRPC3 [Mapview hg38]
OMIM602345   616410   
Gene and transcription
Genbank (Entrez)AB255423 AB255424 AY865574 BC093682 BC093684
RefSeq transcript (Entrez)NM_001130698 NM_003305
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRPC3
Cluster EST : UnigeneHs.150981 [ NCBI ]
CGAP (NCI)Hs.150981
Alternative Splicing GalleryENSG00000138741
Gene ExpressionTRPC3 [ NCBI-GEO ]   TRPC3 [ EBI - ARRAY_EXPRESS ]   TRPC3 [ SEEK ]   TRPC3 [ MEM ]
Gene Expression Viewer (FireBrowse)TRPC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7222
GTEX Portal (Tissue expression)TRPC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13507   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13507  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13507
Splice isoforms : SwissVarQ13507
PhosPhoSitePlusQ13507
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ion_trans_dom    TRP_channel    TRP_dom    TRPC3_channel    TRPC_channel   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    Ion_trans (PF00520)    TRP_2 (PF08344)   
Domain families : Pfam (NCBI)pfam12796    pfam00520    pfam08344   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)TRPC3
DMDM Disease mutations7222
Blocks (Seattle)TRPC3
SuperfamilyQ13507
Human Protein AtlasENSG00000138741
Peptide AtlasQ13507
HPRD15999
IPIIPI00748783   IPI00013681   IPI00966878   IPI00968105   IPI00966128   
Protein Interaction databases
DIP (DOE-UCLA)Q13507
IntAct (EBI)Q13507
FunCoupENSG00000138741
BioGRIDTRPC3
STRING (EMBL)TRPC3
ZODIACTRPC3
Ontologies - Pathways
QuickGOQ13507
Ontology : AmiGOcalcium channel activity  protein binding  plasma membrane  integral component of plasma membrane  calcium ion transport  manganese ion transport  single fertilization  phototransduction  positive regulation of calcium ion transport into cytosol  store-operated calcium channel activity  platelet activation  response to ATP  response to calcium ion  calcium ion transmembrane transport  calcium ion transmembrane transport  inositol 1,4,5 trisphosphate binding  positive regulation of cardiac muscle hypertrophy in response to stress  
Ontology : EGO-EBIcalcium channel activity  protein binding  plasma membrane  integral component of plasma membrane  calcium ion transport  manganese ion transport  single fertilization  phototransduction  positive regulation of calcium ion transport into cytosol  store-operated calcium channel activity  platelet activation  response to ATP  response to calcium ion  calcium ion transmembrane transport  calcium ion transmembrane transport  inositol 1,4,5 trisphosphate binding  positive regulation of cardiac muscle hypertrophy in response to stress  
Pathways : BIOCARTAIon Channels and Their Functional Role in Vascular Endothelium [Genes]   
NDEx NetworkTRPC3
Atlas of Cancer Signalling NetworkTRPC3
Wikipedia pathwaysTRPC3
Orthology - Evolution
OrthoDB7222
GeneTree (enSembl)ENSG00000138741
Phylogenetic Trees/Animal Genes : TreeFamTRPC3
HOVERGENQ13507
HOGENOMQ13507
Homologs : HomoloGeneTRPC3
Homology/Alignments : Family Browser (UCSC)TRPC3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRPC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRPC3
dbVarTRPC3
ClinVarTRPC3
1000_GenomesTRPC3 
Exome Variant ServerTRPC3
ExAC (Exome Aggregation Consortium)TRPC3 (select the gene name)
Genetic variants : HAPMAP7222
Genomic Variants (DGV)TRPC3 [DGVbeta]
DECIPHERTRPC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRPC3 
Mutations
ICGC Data PortalTRPC3 
TCGA Data PortalTRPC3 
Broad Tumor PortalTRPC3
OASIS PortalTRPC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRPC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRPC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRPC3
DgiDB (Drug Gene Interaction Database)TRPC3
DoCM (Curated mutations)TRPC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRPC3 (select a term)
intoGenTRPC3
Cancer3DTRPC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602345    616410   
Orphanet23756   
MedgenTRPC3
Genetic Testing Registry TRPC3
NextProtQ13507 [Medical]
TSGene7222
GENETestsTRPC3
Target ValidationTRPC3
Huge Navigator TRPC3 [HugePedia]
snp3D : Map Gene to Disease7222
BioCentury BCIQTRPC3
ClinGenTRPC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7222
Chemical/Pharm GKB GenePA37008
Clinical trialTRPC3
Miscellaneous
canSAR (ICR)TRPC3 (select the gene name)
Probes
Litterature
PubMed114 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRPC3
EVEXTRPC3
GoPubMedTRPC3
iHOPTRPC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:36:27 CEST 2017

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