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TRPC4 (transient receptor potential cation channel subfamily C member 4)

Identity

Alias_namestransient receptor potential cation channel
Alias_symbol (synonym)HTRP4
TRP4
Other aliasHTRP-4
HGNC (Hugo) TRPC4
LocusID (NCBI) 7223
Atlas_Id 49942
Location 13q13.3  [Link to chromosome band 13q13]
Location_base_pair Starts at 38210773 and ends at 38443939 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SMPD1 (11p15.4) / TRPC4 (13q13.3)TRPC4 (13q13.3) / TRPC4 (13q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRPC4   12336
Cards
Entrez_Gene (NCBI)TRPC4  7223  transient receptor potential cation channel subfamily C member 4
AliasesHTRP-4; HTRP4; TRP4
GeneCards (Weizmann)TRPC4
Ensembl hg19 (Hinxton)ENSG00000133107 [Gene_View]  chr13:38210773-38443939 [Contig_View]  TRPC4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000133107 [Gene_View]  chr13:38210773-38443939 [Contig_View]  TRPC4 [Vega]
ICGC DataPortalENSG00000133107
TCGA cBioPortalTRPC4
AceView (NCBI)TRPC4
Genatlas (Paris)TRPC4
WikiGenes7223
SOURCE (Princeton)TRPC4
Genetics Home Reference (NIH)TRPC4
Genomic and cartography
GoldenPath hg19 (UCSC)TRPC4  -     chr13:38210773-38443939 -  13q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TRPC4  -     13q13.3   [Description]    (hg38-Dec_2013)
EnsemblTRPC4 - 13q13.3 [CytoView hg19]  TRPC4 - 13q13.3 [CytoView hg38]
Mapping of homologs : NCBITRPC4 [Mapview hg19]  TRPC4 [Mapview hg38]
OMIM603651   
Gene and transcription
Genbank (Entrez)AF063822 AF063823 AF063824 AF063825 AF175406
RefSeq transcript (Entrez)NM_001135955 NM_001135956 NM_001135957 NM_001135958 NM_003306 NM_016179
RefSeq genomic (Entrez)NC_000013 NC_018924 NG_029849 NT_024524 NW_004929388
Consensus coding sequences : CCDS (NCBI)TRPC4
Cluster EST : UnigeneHs.262960 [ NCBI ]
CGAP (NCI)Hs.262960
Alternative Splicing GalleryENSG00000133107
Gene ExpressionTRPC4 [ NCBI-GEO ]   TRPC4 [ EBI - ARRAY_EXPRESS ]   TRPC4 [ SEEK ]   TRPC4 [ MEM ]
Gene Expression Viewer (FireBrowse)TRPC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7223
GTEX Portal (Tissue expression)TRPC4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBN4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBN4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBN4
Splice isoforms : SwissVarQ9UBN4
PhosPhoSitePlusQ9UBN4
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    TRP_channel    TRPC4_channel    TRPC_channel   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)TRPC4
DMDM Disease mutations7223
Blocks (Seattle)TRPC4
SuperfamilyQ9UBN4
Human Protein AtlasENSG00000133107
Peptide AtlasQ9UBN4
HPRD09154
IPIIPI00002689   IPI00219492   IPI00219494   IPI00219495   IPI00643379   IPI00044147   IPI01011171   IPI00044148   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBN4
IntAct (EBI)Q9UBN4
FunCoupENSG00000133107
BioGRIDTRPC4
STRING (EMBL)TRPC4
ZODIACTRPC4
Ontologies - Pathways
QuickGOQ9UBN4
Ontology : AmiGOcalcium channel activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  caveola  cell-cell junction  calcium ion transport  manganese ion transport  beta-catenin binding  cell surface  gamma-aminobutyric acid secretion  store-operated calcium channel activity  basolateral plasma membrane  cortical cytoskeleton  calcium channel complex  cadherin binding  oligodendrocyte differentiation  regulation of cytosolic calcium ion concentration  regulation of calcium ion transport  calcium ion import  calcium ion transmembrane transport  inositol 1,4,5 trisphosphate binding  
Ontology : EGO-EBIcalcium channel activity  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  caveola  cell-cell junction  calcium ion transport  manganese ion transport  beta-catenin binding  cell surface  gamma-aminobutyric acid secretion  store-operated calcium channel activity  basolateral plasma membrane  cortical cytoskeleton  calcium channel complex  cadherin binding  oligodendrocyte differentiation  regulation of cytosolic calcium ion concentration  regulation of calcium ion transport  calcium ion import  calcium ion transmembrane transport  inositol 1,4,5 trisphosphate binding  
Pathways : BIOCARTAIon Channels and Their Functional Role in Vascular Endothelium [Genes]   
NDEx NetworkTRPC4
Atlas of Cancer Signalling NetworkTRPC4
Wikipedia pathwaysTRPC4
Orthology - Evolution
OrthoDB7223
GeneTree (enSembl)ENSG00000133107
Phylogenetic Trees/Animal Genes : TreeFamTRPC4
HOVERGENQ9UBN4
HOGENOMQ9UBN4
Homologs : HomoloGeneTRPC4
Homology/Alignments : Family Browser (UCSC)TRPC4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRPC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRPC4
dbVarTRPC4
ClinVarTRPC4
1000_GenomesTRPC4 
Exome Variant ServerTRPC4
ExAC (Exome Aggregation Consortium)TRPC4 (select the gene name)
Genetic variants : HAPMAP7223
Genomic Variants (DGV)TRPC4 [DGVbeta]
DECIPHER (Syndromes)13:38210773-38443939  ENSG00000133107
CONAN: Copy Number AnalysisTRPC4 
Mutations
ICGC Data PortalTRPC4 
TCGA Data PortalTRPC4 
Broad Tumor PortalTRPC4
OASIS PortalTRPC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRPC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRPC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRPC4
DgiDB (Drug Gene Interaction Database)TRPC4
DoCM (Curated mutations)TRPC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRPC4 (select a term)
intoGenTRPC4
Cancer3DTRPC4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603651   
Orphanet
MedgenTRPC4
Genetic Testing Registry TRPC4
NextProtQ9UBN4 [Medical]
TSGene7223
GENETestsTRPC4
Huge Navigator TRPC4 [HugePedia]
snp3D : Map Gene to Disease7223
BioCentury BCIQTRPC4
ClinGenTRPC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7223
Chemical/Pharm GKB GenePA37009
Clinical trialTRPC4
Miscellaneous
canSAR (ICR)TRPC4 (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRPC4
EVEXTRPC4
GoPubMedTRPC4
iHOPTRPC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:23:34 CEST 2017

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