TRPC4 (transient receptor potential cation channel subfamily C member 4)

2007-12-01  

Identity

HGNC
LOCATION
13q13.3
LOCUSID
ALIAS
HTRP-4,HTRP4,TRP4
FUSION GENES

Other Information

Locus ID:

NCBI: 7223
MIM: 603651
HGNC: 12336
Ensembl: ENSG00000133107

Variants:

dbSNP: 7223
ClinVar: 7223
TCGA: ENSG00000133107
COSMIC: TRPC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133107ENST00000338947Q9UBN4
ENSG00000133107ENST00000355779Q9UBN4
ENSG00000133107ENST00000358477Q9UBN4
ENSG00000133107ENST00000379673Q9UBN4
ENSG00000133107ENST00000379679Q9UBN4
ENSG00000133107ENST00000379705Q9UBN4
ENSG00000133107ENST00000426868Q3MHB9
ENSG00000133107ENST00000488717Q9UBN4
ENSG00000133107ENST00000625583Q9UBN4

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Role of second messengers in netrin-1 signalingREACTOMER-HSA-418890

References

Pubmed IDYearTitleCitations
366745532023Expression of pH-Sensitive TRPC4 in Common Skin Tumors.1
368306512023Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4, and Its Expression Correlated with Prognosis, Tumor Microenvironment, and Treatment Sensitivity.4
366745532023Expression of pH-Sensitive TRPC4 in Common Skin Tumors.1
368306512023Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4, and Its Expression Correlated with Prognosis, Tumor Microenvironment, and Treatment Sensitivity.4
341992802021Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.4
348990562021Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.1
341992802021Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.4
348990562021Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.1
307556452019Differential PI(4,5)P(2) sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels.15
307556452019Differential PI(4,5)P(2) sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels.15
294725622018Gα(i)-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation.10
301082722018Dual action of the Gα(q)-PLCβ-PI(4,5)P(2) pathway on TRPC1/4 and TRPC1/5 heterotetramers.22
294725622018Gα(i)-mediated TRPC4 activation by polycystin-1 contributes to endothelial function via STAT1 activation.10
301082722018Dual action of the Gα(q)-PLCβ-PI(4,5)P(2) pathway on TRPC1/4 and TRPC1/5 heterotetramers.22
281858942017TRPC1 and TRPC4 channels functionally interact with STIM1L to promote myogenesis and maintain fast repetitive Ca(2+) release in human myotubes.30

Citation

Dessen P

TRPC4 (transient receptor potential cation channel subfamily C member 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49942/trpc4