TRPC4AP (transient receptor potential cation channel subfamily C member 4 associated protein)

2014-08-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
C20orf188,PPP1R158,TRRP4AP,TRUSS
FUSION GENES

Other Information

Locus ID:

NCBI: 26133
MIM: 608430
HGNC: 16181
Ensembl: ENSG00000100991

Variants:

dbSNP: 26133
ClinVar: 26133
TCGA: ENSG00000100991
COSMIC: TRPC4AP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100991ENST00000252015Q8TEL6
ENSG00000100991ENST00000451813Q8TEL6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205511722010Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells.43
184499082009Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis.24
184499082009Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis.24
260388162015The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2.9
190593082009The frequency of the TRPC4AP haplotype in Alzheimer's patients.2
190593082009The frequency of the TRPC4AP haplotype in Alzheimer's patients.2
204587422010TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.2
297042592018TRUSS Exacerbates NAFLD Development by Promoting IκBα Degradation in Mice.0

Citation

Dessen P

TRPC4AP (transient receptor potential cation channel subfamily C member 4 associated protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54726/trpc4ap