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TRPC4AP (transient receptor potential cation channel subfamily C member 4 associated protein)

Identity

Alias_namesregulatory subunit 158
C20orf188
Alias_symbol (synonym)DKFZP727M231
DKFZp586C1223
dJ756N5.2
TRRP4AP
PPP1R158
Other aliasTRUSS
HGNC (Hugo) TRPC4AP
LocusID (NCBI) 26133
Atlas_Id 54726
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 35002404 and ends at 35092815 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TAF1D (11q21) / TRPC4AP (20q11.22)TRPC4AP (20q11.22) / ACSBG2 (19p13.3)TRPC4AP (20q11.22) / LMF2 (22q13.33)
TRPC4AP (20q11.22) / MRPL45 (17q12)TRPC4AP (20q11.22) / RALY (20q11.22)TRPC4AP (20q11.22) / RPRD1B (20q11.23)
TRPC4AP (20q11.22) / SPG20-AS1 (13q13.3)TRPC4AP (20q11.22) / TMEM245 (9q31.3)TRPC4AP (20q11.22) / TOX2 (20q13.12)
TRPC4AP 20q11.22 C9orf5TRPC4AP 20q11.22 / RALY 20q11.22TRPC4AP 20q11.22 SPG20OS
TRPC4AP 20q11.22 / TOX2 20q13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRPC4AP   16181
Cards
Entrez_Gene (NCBI)TRPC4AP  26133  transient receptor potential cation channel subfamily C member 4 associated protein
AliasesC20orf188; PPP1R158; TRRP4AP; TRUSS
GeneCards (Weizmann)TRPC4AP
Ensembl hg19 (Hinxton)ENSG00000100991 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100991 [Gene_View]  chr20:35002404-35092815 [Contig_View]  TRPC4AP [Vega]
ICGC DataPortalENSG00000100991
TCGA cBioPortalTRPC4AP
AceView (NCBI)TRPC4AP
Genatlas (Paris)TRPC4AP
WikiGenes26133
SOURCE (Princeton)TRPC4AP
Genetics Home Reference (NIH)TRPC4AP
Genomic and cartography
GoldenPath hg38 (UCSC)TRPC4AP  -     chr20:35002404-35092815 -  20q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRPC4AP  -     20q11.22   [Description]    (hg19-Feb_2009)
EnsemblTRPC4AP - 20q11.22 [CytoView hg19]  TRPC4AP - 20q11.22 [CytoView hg38]
Mapping of homologs : NCBITRPC4AP [Mapview hg19]  TRPC4AP [Mapview hg38]
OMIM608430   
Gene and transcription
Genbank (Entrez)AF055022 AK074106 AK298958 AK301368 AK303476
RefSeq transcript (Entrez)NM_015638 NM_199368
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRPC4AP
Cluster EST : UnigeneHs.168073 [ NCBI ]
CGAP (NCI)Hs.168073
Alternative Splicing GalleryENSG00000100991
Gene ExpressionTRPC4AP [ NCBI-GEO ]   TRPC4AP [ EBI - ARRAY_EXPRESS ]   TRPC4AP [ SEEK ]   TRPC4AP [ MEM ]
Gene Expression Viewer (FireBrowse)TRPC4AP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26133
GTEX Portal (Tissue expression)TRPC4AP
Human Protein AtlasENSG00000100991-TRPC4AP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TEL6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TEL6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TEL6
Splice isoforms : SwissVarQ8TEL6
PhosPhoSitePlusQ8TEL6
Domains : Interpro (EBI)ARM-type_fold    DUF3689   
Domain families : Pfam (Sanger)DUF3689 (PF12463)   
Domain families : Pfam (NCBI)pfam12463   
Conserved Domain (NCBI)TRPC4AP
DMDM Disease mutations26133
Blocks (Seattle)TRPC4AP
SuperfamilyQ8TEL6
Human Protein Atlas [tissue]ENSG00000100991-TRPC4AP [tissue]
Peptide AtlasQ8TEL6
HPRD09238
IPIIPI00152769   IPI00219534   IPI00941114   IPI01012134   IPI01012956   IPI00399303   
Protein Interaction databases
DIP (DOE-UCLA)Q8TEL6
IntAct (EBI)Q8TEL6
FunCoupENSG00000100991
BioGRIDTRPC4AP
STRING (EMBL)TRPC4AP
ZODIACTRPC4AP
Ontologies - Pathways
QuickGOQ8TEL6
Ontology : AmiGOcalcium channel activity  protein binding  plasma membrane  ubiquitin-dependent protein catabolic process  protein ubiquitination  protein ubiquitination  phosphatase binding  Cul4A-RING E3 ubiquitin ligase complex  hair follicle maturation  calcium ion transmembrane transport  
Ontology : EGO-EBIcalcium channel activity  protein binding  plasma membrane  ubiquitin-dependent protein catabolic process  protein ubiquitination  protein ubiquitination  phosphatase binding  Cul4A-RING E3 ubiquitin ligase complex  hair follicle maturation  calcium ion transmembrane transport  
NDEx NetworkTRPC4AP
Atlas of Cancer Signalling NetworkTRPC4AP
Wikipedia pathwaysTRPC4AP
Orthology - Evolution
OrthoDB26133
GeneTree (enSembl)ENSG00000100991
Phylogenetic Trees/Animal Genes : TreeFamTRPC4AP
HOVERGENQ8TEL6
HOGENOMQ8TEL6
Homologs : HomoloGeneTRPC4AP
Homology/Alignments : Family Browser (UCSC)TRPC4AP
Gene fusions - Rearrangements
Fusion : MitelmanTRPC4AP/MRPL45 [20q11.22/17q12]  
Fusion : MitelmanTRPC4AP/RALY [20q11.22/20q11.22]  [t(20;20)(q11;q11)]  
Fusion : MitelmanTRPC4AP/SPG20-AS1 [20q11.22/13q13.3]  [t(13;20)(q13;q11)]  
Fusion : MitelmanTRPC4AP/TMEM245 [20q11.22/9q31.3]  [t(9;20)(q31;q11)]  
Fusion : MitelmanTRPC4AP/TOX2 [20q11.22/20q13.12]  [t(20;20)(q11;q13)]  
Fusion: TCGA_MDACCTRPC4AP 20q11.22 C9orf5 BRCA
Fusion: TCGA_MDACCTRPC4AP 20q11.22 RALY 20q11.22 BRCA
Fusion: TCGA_MDACCTRPC4AP 20q11.22 SPG20OS BRCA
Fusion: TCGA_MDACCTRPC4AP 20q11.22 TOX2 20q13.12 BRCA
Tumor Fusion PortalTRPC4AP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRPC4AP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRPC4AP
dbVarTRPC4AP
ClinVarTRPC4AP
1000_GenomesTRPC4AP 
Exome Variant ServerTRPC4AP
ExAC (Exome Aggregation Consortium)ENSG00000100991
GNOMAD BrowserENSG00000100991
Genetic variants : HAPMAP26133
Genomic Variants (DGV)TRPC4AP [DGVbeta]
DECIPHERTRPC4AP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRPC4AP 
Mutations
ICGC Data PortalTRPC4AP 
TCGA Data PortalTRPC4AP 
Broad Tumor PortalTRPC4AP
OASIS PortalTRPC4AP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRPC4AP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRPC4AP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRPC4AP
DgiDB (Drug Gene Interaction Database)TRPC4AP
DoCM (Curated mutations)TRPC4AP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRPC4AP (select a term)
intoGenTRPC4AP
Cancer3DTRPC4AP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608430   
Orphanet
DisGeNETTRPC4AP
MedgenTRPC4AP
Genetic Testing Registry TRPC4AP
NextProtQ8TEL6 [Medical]
TSGene26133
GENETestsTRPC4AP
Target ValidationTRPC4AP
Huge Navigator TRPC4AP [HugePedia]
snp3D : Map Gene to Disease26133
BioCentury BCIQTRPC4AP
ClinGenTRPC4AP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26133
Chemical/Pharm GKB GenePA25730
Clinical trialTRPC4AP
Miscellaneous
canSAR (ICR)TRPC4AP (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRPC4AP
EVEXTRPC4AP
GoPubMedTRPC4AP
iHOPTRPC4AP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:39:52 CET 2017

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