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TRPC5 (transient receptor potential cation channel subfamily C member 5)

Identity

Alias_namesregulatory subunit 159
Alias_symbol (synonym)PPP1R159
Other aliasTRP5
HGNC (Hugo) TRPC5
LocusID (NCBI) 7224
Atlas_Id 53145
Location Xq23  [Link to chromosome band Xq23]
Location_base_pair Starts at 111774314 and ends at 112082776 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TFG (3q12.2) / TRPC5 (Xq23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRPC5   12337
Cards
Entrez_Gene (NCBI)TRPC5  7224  transient receptor potential cation channel subfamily C member 5
AliasesPPP1R159; TRP5
GeneCards (Weizmann)TRPC5
Ensembl hg19 (Hinxton)ENSG00000072315 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000072315 [Gene_View]  chrX:111774314-112082776 [Contig_View]  TRPC5 [Vega]
ICGC DataPortalENSG00000072315
TCGA cBioPortalTRPC5
AceView (NCBI)TRPC5
Genatlas (Paris)TRPC5
WikiGenes7224
SOURCE (Princeton)TRPC5
Genetics Home Reference (NIH)TRPC5
Genomic and cartography
GoldenPath hg38 (UCSC)TRPC5  -     chrX:111774314-112082776 -  Xq23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRPC5  -     Xq23   [Description]    (hg19-Feb_2009)
EnsemblTRPC5 - Xq23 [CytoView hg19]  TRPC5 - Xq23 [CytoView hg38]
Mapping of homologs : NCBITRPC5 [Mapview hg19]  TRPC5 [Mapview hg38]
OMIM300334   
Gene and transcription
Genbank (Entrez)AB209258 AF054568 BC137271 BC137274
RefSeq transcript (Entrez)NM_012471
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRPC5
Cluster EST : UnigeneHs.657709 [ NCBI ]
CGAP (NCI)Hs.657709
Alternative Splicing GalleryENSG00000072315
Gene ExpressionTRPC5 [ NCBI-GEO ]   TRPC5 [ EBI - ARRAY_EXPRESS ]   TRPC5 [ SEEK ]   TRPC5 [ MEM ]
Gene Expression Viewer (FireBrowse)TRPC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7224
GTEX Portal (Tissue expression)TRPC5
Human Protein AtlasENSG00000072315-TRPC5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UL62   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UL62  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UL62
Splice isoforms : SwissVarQ9UL62
PhosPhoSitePlusQ9UL62
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ion_trans_dom    TRP_channel    TRP_dom    TRPC5_channel    TRPC_channel   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    Ion_trans (PF00520)    TRP_2 (PF08344)   
Domain families : Pfam (NCBI)pfam12796    pfam00520    pfam08344   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)TRPC5
DMDM Disease mutations7224
Blocks (Seattle)TRPC5
SuperfamilyQ9UL62
Human Protein Atlas [tissue]ENSG00000072315-TRPC5 [tissue]
Peptide AtlasQ9UL62
HPRD02273
IPIIPI00007836   
Protein Interaction databases
DIP (DOE-UCLA)Q9UL62
IntAct (EBI)Q9UL62
FunCoupENSG00000072315
BioGRIDTRPC5
STRING (EMBL)TRPC5
ZODIACTRPC5
Ontologies - Pathways
QuickGOQ9UL62
Ontology : AmiGOactin binding  calcium channel activity  calcium channel activity  protein binding  cytoplasm  plasma membrane  integral component of plasma membrane  calcium ion transport  manganese ion transport  positive regulation of cytosolic calcium ion concentration  nervous system development  positive regulation of cell proliferation  positive regulation of peptidyl-threonine phosphorylation  store-operated calcium channel activity  neuron differentiation  clathrin binding  dendrite  growth cone  calcium channel complex  actinin binding  neuronal cell body  membrane raft  positive regulation of axon extension  negative regulation of dendrite morphogenesis  ATPase binding  regulation of cytosolic calcium ion concentration  calcium ion transmembrane transport  inositol 1,4,5 trisphosphate binding  regulation of membrane hyperpolarization  
Ontology : EGO-EBIactin binding  calcium channel activity  calcium channel activity  protein binding  cytoplasm  plasma membrane  integral component of plasma membrane  calcium ion transport  manganese ion transport  positive regulation of cytosolic calcium ion concentration  nervous system development  positive regulation of cell proliferation  positive regulation of peptidyl-threonine phosphorylation  store-operated calcium channel activity  neuron differentiation  clathrin binding  dendrite  growth cone  calcium channel complex  actinin binding  neuronal cell body  membrane raft  positive regulation of axon extension  negative regulation of dendrite morphogenesis  ATPase binding  regulation of cytosolic calcium ion concentration  calcium ion transmembrane transport  inositol 1,4,5 trisphosphate binding  regulation of membrane hyperpolarization  
Pathways : BIOCARTAIon Channels and Their Functional Role in Vascular Endothelium [Genes]   
NDEx NetworkTRPC5
Atlas of Cancer Signalling NetworkTRPC5
Wikipedia pathwaysTRPC5
Orthology - Evolution
OrthoDB7224
GeneTree (enSembl)ENSG00000072315
Phylogenetic Trees/Animal Genes : TreeFamTRPC5
HOVERGENQ9UL62
HOGENOMQ9UL62
Homologs : HomoloGeneTRPC5
Homology/Alignments : Family Browser (UCSC)TRPC5
Gene fusions - Rearrangements
Tumor Fusion PortalTRPC5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRPC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRPC5
dbVarTRPC5
ClinVarTRPC5
1000_GenomesTRPC5 
Exome Variant ServerTRPC5
ExAC (Exome Aggregation Consortium)ENSG00000072315
GNOMAD BrowserENSG00000072315
Genetic variants : HAPMAP7224
Genomic Variants (DGV)TRPC5 [DGVbeta]
DECIPHERTRPC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRPC5 
Mutations
ICGC Data PortalTRPC5 
TCGA Data PortalTRPC5 
Broad Tumor PortalTRPC5
OASIS PortalTRPC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRPC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRPC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch TRPC5
DgiDB (Drug Gene Interaction Database)TRPC5
DoCM (Curated mutations)TRPC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRPC5 (select a term)
intoGenTRPC5
Cancer3DTRPC5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300334   
Orphanet
DisGeNETTRPC5
MedgenTRPC5
Genetic Testing Registry TRPC5
NextProtQ9UL62 [Medical]
TSGene7224
GENETestsTRPC5
Target ValidationTRPC5
Huge Navigator TRPC5 [HugePedia]
snp3D : Map Gene to Disease7224
BioCentury BCIQTRPC5
ClinGenTRPC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7224
Chemical/Pharm GKB GenePA37010
Clinical trialTRPC5
Miscellaneous
canSAR (ICR)TRPC5 (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRPC5
EVEXTRPC5
GoPubMedTRPC5
iHOPTRPC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:39:52 CET 2017

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