TRPC5 (transient receptor potential cation channel subfamily C member 5)

2013-01-01  

Identity

HGNC
LOCATION
Xq23
LOCUSID
ALIAS
PPP1R159,TRP5
FUSION GENES

Other Information

Locus ID:

NCBI: 7224
MIM: 300334
HGNC: 12337
Ensembl: ENSG00000072315

Variants:

dbSNP: 7224
ClinVar: 7224
TCGA: ENSG00000072315
COSMIC: TRPC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072315ENST00000262839Q9UL62

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Role of second messengers in netrin-1 signalingREACTOMER-HSA-418890

References

Pubmed IDYearTitleCitations
181724972008TRPC channel activation by extracellular thioredoxin.111
169507852006Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling.90
156472882005A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2.67
220256992011Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system.67
198155602009TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels.50
163686802006Sensing of lysophospholipids by TRPC5 calcium channel.49
186653912009Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels.49
247339042014Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance.43
178848142007Potentiation of TRPC5 by protons.41
229881212012Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells.39

Citation

Dessen P

TRPC5 (transient receptor potential cation channel subfamily C member 5)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53145/trpc5