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TRPM6 (transient receptor potential cation channel subfamily M member 6)

Identity

Alias_namesHOMG
HSH
hypomagnesemia, secondary hypocalcemia
transient receptor potential cation channel, subfamily M, member 6
Alias_symbol (synonym)CHAK2
FLJ22628
Other aliasHMGX
HOMG1
HGNC (Hugo) TRPM6
LocusID (NCBI) 140803
Atlas_Id 43544
Location 9q21.13  [Link to chromosome band 9q21]
Location_base_pair Starts at 74722495 and ends at 74887720 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRPM6   17995
Cards
Entrez_Gene (NCBI)TRPM6  140803  transient receptor potential cation channel subfamily M member 6
AliasesCHAK2; HMGX; HOMG; HOMG1; 
HSH
GeneCards (Weizmann)TRPM6
Ensembl hg19 (Hinxton)ENSG00000119121 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119121 [Gene_View]  chr9:74722495-74887720 [Contig_View]  TRPM6 [Vega]
ICGC DataPortalENSG00000119121
TCGA cBioPortalTRPM6
AceView (NCBI)TRPM6
Genatlas (Paris)TRPM6
WikiGenes140803
SOURCE (Princeton)TRPM6
Genetics Home Reference (NIH)TRPM6
Genomic and cartography
GoldenPath hg38 (UCSC)TRPM6  -     chr9:74722495-74887720 -  9q21.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRPM6  -     9q21.13   [Description]    (hg19-Feb_2009)
EnsemblTRPM6 - 9q21.13 [CytoView hg19]  TRPM6 - 9q21.13 [CytoView hg38]
Mapping of homologs : NCBITRPM6 [Mapview hg19]  TRPM6 [Mapview hg38]
OMIM602014   607009   
Gene and transcription
Genbank (Entrez)AF350881 AF448232 AK000094 AK026281 AK057748
RefSeq transcript (Entrez)NM_001177310 NM_001177311 NM_017662
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRPM6
Cluster EST : UnigeneHs.272225 [ NCBI ]
CGAP (NCI)Hs.272225
Alternative Splicing GalleryENSG00000119121
Gene ExpressionTRPM6 [ NCBI-GEO ]   TRPM6 [ EBI - ARRAY_EXPRESS ]   TRPM6 [ SEEK ]   TRPM6 [ MEM ]
Gene Expression Viewer (FireBrowse)TRPM6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)140803
GTEX Portal (Tissue expression)TRPM6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BX84   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BX84  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BX84
Splice isoforms : SwissVarQ9BX84
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9BX84
Domaine pattern : Prosite (Expaxy)ALPHA_KINASE (PS51158)   
Domains : Interpro (EBI)Ion_trans_dom    Kinase-like_dom    MHCK_EF2_kinase    TRPM6    TRPM_tetra   
Domain families : Pfam (Sanger)Alpha_kinase (PF02816)    Ion_trans (PF00520)    TRPM_tetra (PF16519)   
Domain families : Pfam (NCBI)pfam02816    pfam00520    pfam16519   
Domain families : Smart (EMBL)Alpha_kinase (SM00811)  
Conserved Domain (NCBI)TRPM6
DMDM Disease mutations140803
Blocks (Seattle)TRPM6
SuperfamilyQ9BX84
Human Protein AtlasENSG00000119121
Peptide AtlasQ9BX84
HPRD06112
IPIIPI00151366   IPI00478589   IPI00472524   IPI00438874   IPI00479402   IPI01013358   IPI00438875   IPI00438890   IPI00387064   IPI01012898   
Protein Interaction databases
DIP (DOE-UCLA)Q9BX84
IntAct (EBI)Q9BX84
FunCoupENSG00000119121
BioGRIDTRPM6
STRING (EMBL)TRPM6
ZODIACTRPM6
Ontologies - Pathways
QuickGOQ9BX84
Ontology : AmiGOprotein serine/threonine kinase activity  calcium channel activity  protein binding  ATP binding  plasma membrane  protein phosphorylation  response to toxic substance  integral component of membrane  apical plasma membrane  brush border membrane  metal ion binding  protein tetramerization  calcium ion transmembrane transport  
Ontology : EGO-EBIprotein serine/threonine kinase activity  calcium channel activity  protein binding  ATP binding  plasma membrane  protein phosphorylation  response to toxic substance  integral component of membrane  apical plasma membrane  brush border membrane  metal ion binding  protein tetramerization  calcium ion transmembrane transport  
Pathways : KEGGMineral absorption   
NDEx NetworkTRPM6
Atlas of Cancer Signalling NetworkTRPM6
Wikipedia pathwaysTRPM6
Orthology - Evolution
OrthoDB140803
GeneTree (enSembl)ENSG00000119121
Phylogenetic Trees/Animal Genes : TreeFamTRPM6
HOVERGENQ9BX84
HOGENOMQ9BX84
Homologs : HomoloGeneTRPM6
Homology/Alignments : Family Browser (UCSC)TRPM6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRPM6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRPM6
dbVarTRPM6
ClinVarTRPM6
1000_GenomesTRPM6 
Exome Variant ServerTRPM6
ExAC (Exome Aggregation Consortium)TRPM6 (select the gene name)
Genetic variants : HAPMAP140803
Genomic Variants (DGV)TRPM6 [DGVbeta]
DECIPHERTRPM6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRPM6 
Mutations
ICGC Data PortalTRPM6 
TCGA Data PortalTRPM6 
Broad Tumor PortalTRPM6
OASIS PortalTRPM6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRPM6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRPM6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRPM6
DgiDB (Drug Gene Interaction Database)TRPM6
DoCM (Curated mutations)TRPM6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRPM6 (select a term)
intoGenTRPM6
Cancer3DTRPM6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602014    607009   
Orphanet9282   
MedgenTRPM6
Genetic Testing Registry TRPM6
NextProtQ9BX84 [Medical]
TSGene140803
GENETestsTRPM6
Target ValidationTRPM6
Huge Navigator TRPM6 [HugePedia]
snp3D : Map Gene to Disease140803
BioCentury BCIQTRPM6
ClinGenTRPM6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD140803
Chemical/Pharm GKB GenePA38479
Clinical trialTRPM6
Miscellaneous
canSAR (ICR)TRPM6 (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRPM6
EVEXTRPM6
GoPubMedTRPM6
iHOPTRPM6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:36:29 CEST 2017

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