Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TRPM6 (transient receptor potential cation channel subfamily M member 6)

Identity

Alias (NCBI)CHAK2
HMGX
HOMG
HOMG1
HSH
HGNC (Hugo) TRPM6
HGNC Alias symbCHAK2
FLJ22628
HGNC Previous nameHOMG
 HSH
HGNC Previous namehypomagnesemia, secondary hypocalcemia
 transient receptor potential cation channel, subfamily M, member 6
LocusID (NCBI) 140803
Atlas_Id 43544
Location 9q21.13  [Link to chromosome band 9q21]
Location_base_pair Starts at 74722495 and ends at 74887921 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TRPM6   17995
Cards
Entrez_Gene (NCBI)TRPM6    transient receptor potential cation channel subfamily M member 6
AliasesCHAK2; HMGX; HOMG; HOMG1; 
HSH
GeneCards (Weizmann)TRPM6
Ensembl hg19 (Hinxton)ENSG00000119121 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119121 [Gene_View]  ENSG00000119121 [Sequence]  chr9:74722495-74887921 [Contig_View]  TRPM6 [Vega]
ICGC DataPortalENSG00000119121
TCGA cBioPortalTRPM6
AceView (NCBI)TRPM6
Genatlas (Paris)TRPM6
SOURCE (Princeton)TRPM6
Genetics Home Reference (NIH)TRPM6
Genomic and cartography
GoldenPath hg38 (UCSC)TRPM6  -     chr9:74722495-74887921 -  9q21.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRPM6  -     9q21.13   [Description]    (hg19-Feb_2009)
GoldenPathTRPM6 - 9q21.13 [CytoView hg19]  TRPM6 - 9q21.13 [CytoView hg38]
ImmunoBaseENSG00000119121
Genome Data Viewer NCBITRPM6 [Mapview hg19]  
OMIM602014   607009   
Gene and transcription
Genbank (Entrez)AF350881 AF448232 AK000094 AK026281 AK057748
RefSeq transcript (Entrez)NM_001177310 NM_001177311 NM_017662
Consensus coding sequences : CCDS (NCBI)TRPM6
Gene ExpressionTRPM6 [ NCBI-GEO ]   TRPM6 [ EBI - ARRAY_EXPRESS ]   TRPM6 [ SEEK ]   TRPM6 [ MEM ]
Gene Expression Viewer (FireBrowse)TRPM6 [ Firebrowse - Broad ]
GenevisibleExpression of TRPM6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)140803
GTEX Portal (Tissue expression)TRPM6
Human Protein AtlasENSG00000119121-TRPM6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BX84   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BX84  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BX84
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9BX84
Domaine pattern : Prosite (Expaxy)ALPHA_KINASE (PS51158)   
Domains : Interpro (EBI)Ion_trans_dom    Kinase-like_dom_sf    MHCK_EF2_kinase    TRPM6    TRPM_SLOG    TRPM_tetra    TRPM_tetra_sf   
Domain families : Pfam (Sanger)Alpha_kinase (PF02816)    Ion_trans (PF00520)    LSDAT_euk (PF18139)    TRPM_tetra (PF16519)   
Domain families : Pfam (NCBI)pfam02816    pfam00520    pfam18139    pfam16519   
Domain families : Smart (EMBL)Alpha_kinase (SM00811)  
Conserved Domain (NCBI)TRPM6
SuperfamilyQ9BX84
AlphaFold pdb e-kbQ9BX84   
Human Protein Atlas [tissue]ENSG00000119121-TRPM6 [tissue]
HPRD06112
Protein Interaction databases
DIP (DOE-UCLA)Q9BX84
IntAct (EBI)Q9BX84
BioGRIDTRPM6
STRING (EMBL)TRPM6
ZODIACTRPM6
Ontologies - Pathways
QuickGOQ9BX84
Ontology : AmiGOcation channel activity  calcium channel activity  protein binding  ATP binding  plasma membrane  integral component of plasma membrane  protein phosphorylation  response to toxic substance  apical plasma membrane  brush border membrane  metal ion binding  protein tetramerization  calcium ion transmembrane transport  cation transmembrane transport  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIcation channel activity  calcium channel activity  protein binding  ATP binding  plasma membrane  integral component of plasma membrane  protein phosphorylation  response to toxic substance  apical plasma membrane  brush border membrane  metal ion binding  protein tetramerization  calcium ion transmembrane transport  cation transmembrane transport  protein serine kinase activity  protein threonine kinase activity  
Pathways : KEGGMineral absorption   
NDEx NetworkTRPM6
Atlas of Cancer Signalling NetworkTRPM6
Wikipedia pathwaysTRPM6
Orthology - Evolution
OrthoDB140803
GeneTree (enSembl)ENSG00000119121
Phylogenetic Trees/Animal Genes : TreeFamTRPM6
Homologs : HomoloGeneTRPM6
Homology/Alignments : Family Browser (UCSC)TRPM6
Gene fusions - Rearrangements
Fusion : QuiverTRPM6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRPM6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRPM6
dbVarTRPM6
ClinVarTRPM6
MonarchTRPM6
1000_GenomesTRPM6 
Exome Variant ServerTRPM6
GNOMAD BrowserENSG00000119121
Varsome BrowserTRPM6
ACMGTRPM6 variants
VarityQ9BX84
Genomic Variants (DGV)TRPM6 [DGVbeta]
DECIPHERTRPM6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRPM6 
Mutations
ICGC Data PortalTRPM6 
TCGA Data PortalTRPM6 
Broad Tumor PortalTRPM6
OASIS PortalTRPM6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRPM6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRPM6
Mutations and Diseases : HGMDTRPM6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRPM6
DgiDB (Drug Gene Interaction Database)TRPM6
DoCM (Curated mutations)TRPM6
CIViC (Clinical Interpretations of Variants in Cancer)TRPM6
Cancer3DTRPM6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602014    607009   
Orphanet9282   
DisGeNETTRPM6
MedgenTRPM6
Genetic Testing Registry TRPM6
NextProtQ9BX84 [Medical]
GENETestsTRPM6
Target ValidationTRPM6
Huge Navigator TRPM6 [HugePedia]
ClinGenTRPM6
Clinical trials, drugs, therapy
MyCancerGenomeTRPM6
Protein Interactions : CTDTRPM6
Pharm GKB GenePA38479
PharosQ9BX84
Clinical trialTRPM6
Miscellaneous
canSAR (ICR)TRPM6
HarmonizomeTRPM6
DataMed IndexTRPM6
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRPM6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:36:32 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.