Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TRPM7 (transient receptor potential cation channel subfamily M member 7)

Identity

Alias_namestransient receptor potential cation channel
Alias_symbol (synonym)CHAK1
LTRPC7
TRP-PLIK
Other aliasALSPDC
CHAK
LTrpC-7
HGNC (Hugo) TRPM7
LocusID (NCBI) 54822
Atlas_Id 43545
Location 15q21.2  [Link to chromosome band 15q21]
Location_base_pair Starts at 50849356 and ends at 50979012 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TRPM7 (15q21.2) / FAM227B (15q21.2)TRPM7 (15q21.2) / TMEM104 (17q25.1)USP8 (15q21.2) / TRPM7 (15q21.2)
TRPM7 15q21.2 C15orf33TRPM7 15q21.2 / TMEM104 17q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)TRPM7   17994
Cards
Entrez_Gene (NCBI)TRPM7  54822  transient receptor potential cation channel subfamily M member 7
AliasesALSPDC; CHAK; CHAK1; LTRPC7; 
LTrpC-7; TRP-PLIK
GeneCards (Weizmann)TRPM7
Ensembl hg19 (Hinxton)ENSG00000092439 [Gene_View]  chr15:50849356-50979012 [Contig_View]  TRPM7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000092439 [Gene_View]  chr15:50849356-50979012 [Contig_View]  TRPM7 [Vega]
ICGC DataPortalENSG00000092439
TCGA cBioPortalTRPM7
AceView (NCBI)TRPM7
Genatlas (Paris)TRPM7
WikiGenes54822
SOURCE (Princeton)TRPM7
Genetics Home Reference (NIH)TRPM7
Genomic and cartography
GoldenPath hg19 (UCSC)TRPM7  -     chr15:50849356-50979012 -  15q21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TRPM7  -     15q21.2   [Description]    (hg38-Dec_2013)
EnsemblTRPM7 - 15q21.2 [CytoView hg19]  TRPM7 - 15q21.2 [CytoView hg38]
Mapping of homologs : NCBITRPM7 [Mapview hg19]  TRPM7 [Mapview hg38]
OMIM105500   605692   
Gene and transcription
Genbank (Entrez)AF346629 AK000124 AK075193 AK098584 AK172800
RefSeq transcript (Entrez)NM_001301212 NM_017672
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_021363 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)TRPM7
Cluster EST : UnigeneHs.512894 [ NCBI ]
CGAP (NCI)Hs.512894
Alternative Splicing GalleryENSG00000092439
Gene ExpressionTRPM7 [ NCBI-GEO ]   TRPM7 [ EBI - ARRAY_EXPRESS ]   TRPM7 [ SEEK ]   TRPM7 [ MEM ]
Gene Expression Viewer (FireBrowse)TRPM7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54822
GTEX Portal (Tissue expression)TRPM7
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96QT4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96QT4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96QT4
Splice isoforms : SwissVarQ96QT4
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ96QT4
Domaine pattern : Prosite (Expaxy)ALPHA_KINASE (PS51158)   
Domains : Interpro (EBI)Ion_trans_dom    Kinase-like_dom    MHCK_EF2_kinase    TRPM7    TRPM_tetra   
Domain families : Pfam (Sanger)Alpha_kinase (PF02816)    Ion_trans (PF00520)    TRPM_tetra (PF16519)   
Domain families : Pfam (NCBI)pfam02816    pfam00520    pfam16519   
Domain families : Smart (EMBL)Alpha_kinase (SM00811)  
Conserved Domain (NCBI)TRPM7
DMDM Disease mutations54822
Blocks (Seattle)TRPM7
SuperfamilyQ96QT4
Human Protein AtlasENSG00000092439
Peptide AtlasQ96QT4
HPRD10418
IPIIPI00290032   
Protein Interaction databases
DIP (DOE-UCLA)Q96QT4
IntAct (EBI)Q96QT4
FunCoupENSG00000092439
BioGRIDTRPM7
STRING (EMBL)TRPM7
ZODIACTRPM7
Ontologies - Pathways
QuickGOQ96QT4
Ontology : AmiGOruffle  actin binding  protein serine/threonine kinase activity  calcium channel activity  ATP binding  plasma membrane  cellular magnesium ion homeostasis  integral component of membrane  calcium-dependent cell-matrix adhesion  myosin binding  actomyosin structure organization  protein autophosphorylation  metal ion binding  protein tetramerization  necroptotic process  calcium ion transmembrane transport  
Ontology : EGO-EBIruffle  actin binding  protein serine/threonine kinase activity  calcium channel activity  ATP binding  plasma membrane  cellular magnesium ion homeostasis  integral component of membrane  calcium-dependent cell-matrix adhesion  myosin binding  actomyosin structure organization  protein autophosphorylation  metal ion binding  protein tetramerization  necroptotic process  calcium ion transmembrane transport  
Pathways : KEGGMineral absorption   
NDEx NetworkTRPM7
Atlas of Cancer Signalling NetworkTRPM7
Wikipedia pathwaysTRPM7
Orthology - Evolution
OrthoDB54822
GeneTree (enSembl)ENSG00000092439
Phylogenetic Trees/Animal Genes : TreeFamTRPM7
HOVERGENQ96QT4
HOGENOMQ96QT4
Homologs : HomoloGeneTRPM7
Homology/Alignments : Family Browser (UCSC)TRPM7
Gene fusions - Rearrangements
Fusion : MitelmanTRPM7/FAM227B [15q21.2/15q21.2]  
Fusion : MitelmanTRPM7/TMEM104 [15q21.2/17q25.1]  [t(15;17)(q21;q25)]  
Fusion: TCGATRPM7 15q21.2 C15orf33 BRCA
Fusion: TCGATRPM7 15q21.2 TMEM104 17q25.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRPM7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRPM7
dbVarTRPM7
ClinVarTRPM7
1000_GenomesTRPM7 
Exome Variant ServerTRPM7
ExAC (Exome Aggregation Consortium)TRPM7 (select the gene name)
Genetic variants : HAPMAP54822
Genomic Variants (DGV)TRPM7 [DGVbeta]
DECIPHER (Syndromes)15:50849356-50979012  ENSG00000092439
CONAN: Copy Number AnalysisTRPM7 
Mutations
ICGC Data PortalTRPM7 
TCGA Data PortalTRPM7 
Broad Tumor PortalTRPM7
OASIS PortalTRPM7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRPM7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRPM7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRPM7
DgiDB (Drug Gene Interaction Database)TRPM7
DoCM (Curated mutations)TRPM7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRPM7 (select a term)
intoGenTRPM7
Cancer3DTRPM7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM105500    605692   
Orphanet11922   
MedgenTRPM7
Genetic Testing Registry TRPM7
NextProtQ96QT4 [Medical]
TSGene54822
GENETestsTRPM7
Huge Navigator TRPM7 [HugePedia]
snp3D : Map Gene to Disease54822
BioCentury BCIQTRPM7
ClinGenTRPM7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54822
Chemical/Pharm GKB GenePA38273
Clinical trialTRPM7
Miscellaneous
canSAR (ICR)TRPM7 (select the gene name)
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRPM7
EVEXTRPM7
GoPubMedTRPM7
iHOPTRPM7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:23:36 CEST 2017

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