TRPM7 (transient receptor potential cation channel subfamily M member 7)

2006-10-01  

Identity

HGNC
LOCATION
15q21.2
LOCUSID
ALIAS
ALSPDC,CHAK,CHAK1,LTRPC7,LTrpC-7,TRP-PLIK
FUSION GENES

Other Information

Locus ID:

NCBI: 54822
MIM: 605692
HGNC: 17994
Ensembl: ENSG00000092439

Variants:

dbSNP: 54822
ClinVar: 54822
TCGA: ENSG00000092439
COSMIC: TRPM7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092439ENST00000560638A0A0C4DGL2
ENSG00000092439ENST00000560955H0YLN8
ENSG00000092439ENST00000561267H0YNM0
ENSG00000092439ENST00000646667Q96QT4
ENSG00000092439ENST00000646667A0A024R5V1

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
166362022006Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.153
164079772006TRPM7, a novel regulator of actomyosin contractility and cell adhesion.120
200753342010TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation.96
164363822006TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain.83
163573062006Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow.77
165338982006TRPM7 channel is regulated by magnesium nucleotides via its kinase domain.72
195159012009Evidence that TRPM7 is required for breast cancer cell proliferation.66
228713862012TRPM7 is required for breast tumor cell metastasis.65
169432382007TRPM7 is a stretch- and swelling-activated cation channel involved in volume regulation in human epithelial cells.62
150691882004Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain.58

Citation

Dessen P

TRPM7 (transient receptor potential cation channel subfamily M member 7)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43545/trpm7