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TRPS1 (transcriptional repressor GATA binding 1)

Identity

Other namesGC79
LGCR
HGNC (Hugo) TRPS1
LocusID (NCBI) 7227
Atlas_Id 430
Location 8q23.3
Location_base_pair Starts at 116420724 and ends at 116680239 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AKAP9 (7q21.2) / TRPS1 (8q23.3)PCID2 (13q34) / TRPS1 (8q23.3)RUNX1 (21q22.12) / TRPS1 (8q23.3)
SPARC (5q33.1) / TRPS1 (8q23.3)TRPS1 (8q23.3) / C19orf66 (19p13.2)TRPS1 (8q23.3) / CHRAC1 (8q24.3)
TRPS1 (8q23.3) / DEPTOR (8q24.12)TRPS1 (8q23.3) / LASP1 (17q12)TRPS1 (8q23.3) / LRP12 (8q22.3)
TRPS1 (8q23.3) / PAFAH1B1 (17p13.3)TRPS1 (8q23.3) / PCGF5 (10q23.32)TRPS1 (8q23.3) / PDE4DIP (1q21.1)
TRPS1 (8q23.3) / RAD21 (8q24.11)TRPS1 (8q23.3) / RP11-664D7.4 ()TRPS1 (8q23.3) / SPAG1 (8q22.2)
TRPS1 (8q23.3) / SPTBN1 (2p16.2)TRPS1 (8q23.3) / TBC1D9B (5q35.3)TRPS1 (8q23.3) / TRPS1 (8q23.3)
TRPS1 (8q23.3) / WWC3 (Xp22.2)TRPS1 (8q23.3) / ZNRF2 (7p14.3)TRPS1 8q23.3 / C19orf66 19p13.2
TRPS1 8q23.3 / CHRAC1 8q24.3TRPS1 8q23.3 / DEPTOR 8q24.12TRPS1 8q23.3 / LRP12 8q22.3
TRPS1 8q23.3 / PAFAH1B1 17p13.3TRPS1 8q23.3 / PDE4DIP 1q21.1TRPS1 8q23.3 / RAD21 8q24.11
TRPS1 8q23.3 RP11-664D7.4TRPS1 8q23.3 / SPAG1 8q22.2TRPS1 8q23.3 / TBC1D9B 5q35.3
TRPS1 8q23.3 / ZNRF2 7p14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;21)(q24;q22) RUNX1/TRPS1

External links

Nomenclature
HGNC (Hugo)TRPS1   12340
Cards
Entrez_Gene (NCBI)TRPS1  7227  transcriptional repressor GATA binding 1
GeneCards (Weizmann)TRPS1
Ensembl hg19 (Hinxton)ENSG00000104447 [Gene_View]  chr8:116420724-116680239 [Contig_View]  TRPS1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000104447 [Gene_View]  chr8:116420724-116680239 [Contig_View]  TRPS1 [Vega]
ICGC DataPortalENSG00000104447
TCGA cBioPortalTRPS1
AceView (NCBI)TRPS1
Genatlas (Paris)TRPS1
WikiGenes7227
SOURCE (Princeton)TRPS1
Genomic and cartography
GoldenPath hg19 (UCSC)TRPS1  -     chr8:116420724-116680239 -  8q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TRPS1  -     8q23.3   [Description]    (hg38-Dec_2013)
EnsemblTRPS1 - 8q23.3 [CytoView hg19]  TRPS1 - 8q23.3 [CytoView hg38]
Mapping of homologs : NCBITRPS1 [Mapview hg19]  TRPS1 [Mapview hg38]
OMIM190350   190351   604386   
Gene and transcription
Genbank (Entrez)AF183810 AF264784 AK000948 AK021470 AK021511
RefSeq transcript (Entrez)NM_001282902 NM_001282903 NM_014112
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_012383 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)TRPS1
Cluster EST : UnigeneHs.657018 [ NCBI ]
CGAP (NCI)Hs.657018
Alternative Splicing : Fast-db (Paris)GSHG0029790
Alternative Splicing GalleryENSG00000104447
Gene ExpressionTRPS1 [ NCBI-GEO ]   TRPS1 [ EBI - ARRAY_EXPRESS ]   TRPS1 [ SEEK ]   TRPS1 [ MEM ]
Gene Expression Viewer (FireBrowse)TRPS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)7227
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHF7 (Uniprot)
NextProtQ9UHF7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHF7
Splice isoforms : SwissVarQ9UHF7 (Swissvar)
PhosPhoSitePlusQ9UHF7
Domaine pattern : Prosite (Expaxy)GATA_ZN_FINGER_1 (PS00344)    GATA_ZN_FINGER_2 (PS50114)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Trps1    Znf_C2H2    Znf_C2H2-like    Znf_GATA    Znf_NHR/GATA   
Domain families : Pfam (Sanger)GATA (PF00320)   
Domain families : Pfam (NCBI)pfam00320   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  ZnF_GATA (SM00401)  
DMDM Disease mutations7227
Blocks (Seattle)TRPS1
SuperfamilyQ9UHF7
Human Protein AtlasENSG00000104447
Peptide AtlasQ9UHF7
HPRD05091
IPIIPI00296078   IPI00853099   IPI00937887   IPI00852690   IPI00852825   IPI00853380   IPI00983416   IPI00973868   IPI00979468   IPI01013632   IPI01013586   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHF7
IntAct (EBI)Q9UHF7
FunCoupENSG00000104447
BioGRIDTRPS1
STRING (EMBL)TRPS1
ZODIACTRPS1
Ontologies - Pathways
QuickGOQ9UHF7
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  skeletal system development  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  transcription factor complex  transcription from RNA polymerase II promoter  NLS-bearing protein import into nucleus  heart development  zinc ion binding  organ morphogenesis  tissue development  regulation of histone deacetylation  regulation of chondrocyte differentiation  cell fate commitment  positive regulation of transcription from RNA polymerase II promoter  cell development  digestive tract development  anatomical structure formation involved in morphogenesis  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  skeletal system development  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  transcription factor complex  transcription from RNA polymerase II promoter  NLS-bearing protein import into nucleus  heart development  zinc ion binding  organ morphogenesis  tissue development  regulation of histone deacetylation  regulation of chondrocyte differentiation  cell fate commitment  positive regulation of transcription from RNA polymerase II promoter  cell development  digestive tract development  anatomical structure formation involved in morphogenesis  
NDEx Network
Atlas of Cancer Signalling NetworkTRPS1
Wikipedia pathwaysTRPS1
Orthology - Evolution
OrthoDB7227
GeneTree (enSembl)ENSG00000104447
Phylogenetic Trees/Animal Genes : TreeFamTRPS1
Homologs : HomoloGeneTRPS1
Homology/Alignments : Family Browser (UCSC)TRPS1
Gene fusions - Rearrangements
Fusion: TCGATRPS1 8q23.3 C19orf66 19p13.2 BRCA
Fusion: TCGATRPS1 8q23.3 CHRAC1 8q24.3 BRCA
Fusion: TCGATRPS1 8q23.3 DEPTOR 8q24.12 LGG
Fusion: TCGATRPS1 8q23.3 LRP12 8q22.3 BRCA
Fusion: TCGATRPS1 8q23.3 PAFAH1B1 17p13.3 BRCA
Fusion: TCGATRPS1 8q23.3 PDE4DIP 1q21.1 BRCA
Fusion: TCGATRPS1 8q23.3 RAD21 8q24.11 BRCA
Fusion: TCGATRPS1 8q23.3 RP11-664D7.4 BRCA
Fusion: TCGATRPS1 8q23.3 SPAG1 8q22.2 BRCA
Fusion: TCGATRPS1 8q23.3 TBC1D9B 5q35.3 BRCA
Fusion: TCGATRPS1 8q23.3 ZNRF2 7p14.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerTRPS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRPS1
dbVarTRPS1
ClinVarTRPS1
1000_GenomesTRPS1 
Exome Variant ServerTRPS1
ExAC (Exome Aggregation Consortium)TRPS1 (select the gene name)
SNP (GeneSNP Utah)TRPS1
SNP : HGBaseTRPS1
Genetic variants : HAPMAPTRPS1
Genomic Variants (DGV)TRPS1 [DGVbeta]
Mutations
ICGC Data PortalTRPS1 
TCGA Data PortalTRPS1 
Broad Tumor PortalTRPS1
OASIS PortalTRPS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRPS1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRPS1
DgiDB (Drug Gene Interaction Database)TRPS1
DoCM (Curated mutations)TRPS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRPS1 (select a term)
intoGenTRPS1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)8:116420724-116680239
CONAN: Copy Number AnalysisTRPS1 
Mutations and Diseases : HGMDTRPS1
OMIM190350    190351    604386   
MedgenTRPS1
Genetic Testing Registry TRPS1
NextProtQ9UHF7 [Medical]
TSGene7227
GENETestsTRPS1
Huge Navigator TRPS1 [HugePedia]  TRPS1 [HugeCancerGEM]
snp3D : Map Gene to Disease7227
BioCentury BCIQTRPS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7227
Chemical/Pharm GKB GenePA37013
Clinical trialTRPS1
Miscellaneous
canSAR (ICR)TRPS1 (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRPS1
GoPubMedTRPS1
iHOPTRPS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 18:08:33 CEST 2016

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