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TSEN2 (tRNA splicing endonuclease subunit 2)

Identity

Alias (NCBI)PCH2B
SEN2
SEN2L
HGNC (Hugo) TSEN2
HGNC Alias symbSEN2
SEN2L
MGC2776
HGNC Previous nametRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae)
 tRNA splicing endonuclease 2 homolog (S. cerevisiae)
 TSEN2 tRNA splicing endonuclease subunit
LocusID (NCBI) 80746
Atlas_Id 75222
Location 3p25.2  [Link to chromosome band 3p25]
Location_base_pair Starts at 12484480 and ends at 12533658 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GATM (15q21.1) / TSEN2 (3p25.2)TSEN2 (3p25.2) / MIR548G (3q12.1)TSEN2 (3p25.2) / PPARG (3p25.2)
TSEN2 (3p25.2) / TSEN2 (3p25.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TSEN2   28422
Cards
Entrez_Gene (NCBI)TSEN2    tRNA splicing endonuclease subunit 2
AliasesPCH2B; SEN2; SEN2L
GeneCards (Weizmann)TSEN2
Ensembl hg19 (Hinxton)ENSG00000154743 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154743 [Gene_View]  ENSG00000154743 [Sequence]  chr3:12484480-12533658 [Contig_View]  TSEN2 [Vega]
ICGC DataPortalENSG00000154743
TCGA cBioPortalTSEN2
AceView (NCBI)TSEN2
Genatlas (Paris)TSEN2
SOURCE (Princeton)TSEN2
Genetics Home Reference (NIH)TSEN2
Genomic and cartography
GoldenPath hg38 (UCSC)TSEN2  -     chr3:12484480-12533658 +  3p25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TSEN2  -     3p25.2   [Description]    (hg19-Feb_2009)
GoldenPathTSEN2 - 3p25.2 [CytoView hg19]  TSEN2 - 3p25.2 [CytoView hg38]
ImmunoBaseENSG00000154743
Genome Data Viewer NCBITSEN2 [Mapview hg19]  
OMIM608753   612389   
Gene and transcription
Genbank (Entrez)AF086155 AK027821 AK074794 AK225875 AK291183
RefSeq transcript (Entrez)NM_001145392 NM_001145393 NM_001145394 NM_001145395 NM_001321277 NM_001321278 NM_001321279 NM_025265
Consensus coding sequences : CCDS (NCBI)TSEN2
Gene ExpressionTSEN2 [ NCBI-GEO ]   TSEN2 [ EBI - ARRAY_EXPRESS ]   TSEN2 [ SEEK ]   TSEN2 [ MEM ]
Gene Expression Viewer (FireBrowse)TSEN2 [ Firebrowse - Broad ]
GenevisibleExpression of TSEN2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80746
GTEX Portal (Tissue expression)TSEN2
Human Protein AtlasENSG00000154743-TSEN2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NCE0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NCE0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NCE0
Catalytic activity : Enzyme4.6.1.16 [ Enzyme-Expasy ]   4.6.1.164.6.1.16 [ IntEnz-EBI ]   4.6.1.16 [ BRENDA ]   4.6.1.16 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ8NCE0
Domains : Interpro (EBI)tRNA_endonuc-like_dom_sf    tRNA_intron_Endo_cat-like_sf    tRNA_intron_Endonuc_cat-like    tRNA_intron_Endonuc_N    tRNA_splic    tRNA_splic_SEN2   
Domain families : Pfam (Sanger)tRNA_int_endo (PF01974)    tRNA_int_endo_N (PF02778)   
Domain families : Pfam (NCBI)pfam01974    pfam02778   
Conserved Domain (NCBI)TSEN2
SuperfamilyQ8NCE0
AlphaFold pdb e-kbQ8NCE0   
Human Protein Atlas [tissue]ENSG00000154743-TSEN2 [tissue]
HPRD10576
Protein Interaction databases
DIP (DOE-UCLA)Q8NCE0
IntAct (EBI)Q8NCE0
BioGRIDTSEN2
STRING (EMBL)TSEN2
ZODIACTSEN2
Ontologies - Pathways
QuickGOQ8NCE0
Ontology : AmiGOtRNA-intron endonuclease activity  tRNA-intron endonuclease complex  tRNA-type intron splice site recognition and cleavage  nucleic acid binding  protein binding  nucleoplasm  nucleoplasm  nucleolus  centrosome  cytosol  tRNA splicing, via endonucleolytic cleavage and ligation  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA processing  lyase activity  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBItRNA-intron endonuclease activity  tRNA-intron endonuclease complex  tRNA-type intron splice site recognition and cleavage  nucleic acid binding  protein binding  nucleoplasm  nucleoplasm  nucleolus  centrosome  cytosol  tRNA splicing, via endonucleolytic cleavage and ligation  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA processing  lyase activity  RNA phosphodiester bond hydrolysis, endonucleolytic  
NDEx NetworkTSEN2
Atlas of Cancer Signalling NetworkTSEN2
Wikipedia pathwaysTSEN2
Orthology - Evolution
OrthoDB80746
GeneTree (enSembl)ENSG00000154743
Phylogenetic Trees/Animal Genes : TreeFamTSEN2
Homologs : HomoloGeneTSEN2
Homology/Alignments : Family Browser (UCSC)TSEN2
Gene fusions - Rearrangements
Fusion : QuiverTSEN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSEN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSEN2
dbVarTSEN2
ClinVarTSEN2
MonarchTSEN2
1000_GenomesTSEN2 
Exome Variant ServerTSEN2
GNOMAD BrowserENSG00000154743
Varsome BrowserTSEN2
ACMGTSEN2 variants
VarityQ8NCE0
Genomic Variants (DGV)TSEN2 [DGVbeta]
DECIPHERTSEN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTSEN2 
Mutations
ICGC Data PortalTSEN2 
TCGA Data PortalTSEN2 
Broad Tumor PortalTSEN2
OASIS PortalTSEN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSEN2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTSEN2
Mutations and Diseases : HGMDTSEN2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTSEN2
DgiDB (Drug Gene Interaction Database)TSEN2
DoCM (Curated mutations)TSEN2
CIViC (Clinical Interpretations of Variants in Cancer)TSEN2
Cancer3DTSEN2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608753    612389   
Orphanet2334   
DisGeNETTSEN2
MedgenTSEN2
Genetic Testing Registry TSEN2
NextProtQ8NCE0 [Medical]
GENETestsTSEN2
Target ValidationTSEN2
Huge Navigator TSEN2 [HugePedia]
ClinGenTSEN2
Clinical trials, drugs, therapy
MyCancerGenomeTSEN2
Protein Interactions : CTDTSEN2
Pharm GKB GenePA142670695
PharosQ8NCE0
Clinical trialTSEN2
Miscellaneous
canSAR (ICR)TSEN2
HarmonizomeTSEN2
DataMed IndexTSEN2
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTSEN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:27:06 CEST 2021

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