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TSEN2 (TSEN2 tRNA splicing endonuclease subunit)

Identity

Alias_namestRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae)
tRNA splicing endonuclease 2 homolog (S. cerevisiae)
TSEN2 tRNA splicing endonuclease subunit
Alias_symbol (synonym)SEN2
SEN2L
MGC2776
Other aliasPCH2B
HGNC (Hugo) TSEN2
LocusID (NCBI) 80746
Atlas_Id 75222
Location 3p25.2  [Link to chromosome band 3p25]
Location_base_pair Starts at 12526010 and ends at 12574820 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GATM (15q21.1) / TSEN2 (3p25.2)TSEN2 (3p25.2) / MIR548G (3q12.1)TSEN2 (3p25.2) / PPARG (3p25.2)
TSEN2 (3p25.2) / TSEN2 (3p25.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TSEN2   28422
Cards
Entrez_Gene (NCBI)TSEN2  80746  TSEN2 tRNA splicing endonuclease subunit
AliasesPCH2B; SEN2; SEN2L
GeneCards (Weizmann)TSEN2
Ensembl hg19 (Hinxton)ENSG00000154743 [Gene_View]  chr3:12526010-12574820 [Contig_View]  TSEN2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000154743 [Gene_View]  chr3:12526010-12574820 [Contig_View]  TSEN2 [Vega]
ICGC DataPortalENSG00000154743
TCGA cBioPortalTSEN2
AceView (NCBI)TSEN2
Genatlas (Paris)TSEN2
WikiGenes80746
SOURCE (Princeton)TSEN2
Genetics Home Reference (NIH)TSEN2
Genomic and cartography
GoldenPath hg19 (UCSC)TSEN2  -     chr3:12526010-12574820 +  3p25.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TSEN2  -     3p25.2   [Description]    (hg38-Dec_2013)
EnsemblTSEN2 - 3p25.2 [CytoView hg19]  TSEN2 - 3p25.2 [CytoView hg38]
Mapping of homologs : NCBITSEN2 [Mapview hg19]  TSEN2 [Mapview hg38]
OMIM608753   612389   
Gene and transcription
Genbank (Entrez)AF086155 AK027821 AK074794 AK225875 AK291183
RefSeq transcript (Entrez)NM_001145392 NM_001145393 NM_001145394 NM_001145395 NM_025265
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_011521 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)TSEN2
Cluster EST : UnigeneHs.670039 [ NCBI ]
CGAP (NCI)Hs.670039
Alternative Splicing GalleryENSG00000154743
Gene ExpressionTSEN2 [ NCBI-GEO ]   TSEN2 [ EBI - ARRAY_EXPRESS ]   TSEN2 [ SEEK ]   TSEN2 [ MEM ]
Gene Expression Viewer (FireBrowse)TSEN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80746
GTEX Portal (Tissue expression)TSEN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NCE0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NCE0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NCE0
Splice isoforms : SwissVarQ8NCE0
Catalytic activity : Enzyme4.6.1.16 [ Enzyme-Expasy ]   4.6.1.164.6.1.16 [ IntEnz-EBI ]   4.6.1.16 [ BRENDA ]   4.6.1.16 [ KEGG ]   
PhosPhoSitePlusQ8NCE0
Domains : Interpro (EBI)tRNA_endonuc-like_dom    tRNA_intron_Endonuc_cat-like    tRNA_intron_Endonuc_N    tRNA_splic    tRNA_splic_SEN2   
Domain families : Pfam (Sanger)tRNA_int_endo (PF01974)    tRNA_int_endo_N (PF02778)   
Domain families : Pfam (NCBI)pfam01974    pfam02778   
Conserved Domain (NCBI)TSEN2
DMDM Disease mutations80746
Blocks (Seattle)TSEN2
SuperfamilyQ8NCE0
Human Protein AtlasENSG00000154743
Peptide AtlasQ8NCE0
HPRD10576
IPIIPI00427037   IPI00427039   IPI00427040   IPI00921927   IPI00790771   IPI00926682   IPI00926919   IPI00952977   IPI00926243   
Protein Interaction databases
DIP (DOE-UCLA)Q8NCE0
IntAct (EBI)Q8NCE0
FunCoupENSG00000154743
BioGRIDTSEN2
STRING (EMBL)TSEN2
ZODIACTSEN2
Ontologies - Pathways
QuickGOQ8NCE0
Ontology : AmiGOtRNA-intron endonuclease activity  tRNA-intron endonuclease complex  tRNA-type intron splice site recognition and cleavage  nucleic acid binding  protein binding  nucleoplasm  nucleolus  cytoplasm  centrosome  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA processing  lyase activity  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, endonucleolytic  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBItRNA-intron endonuclease activity  tRNA-intron endonuclease complex  tRNA-type intron splice site recognition and cleavage  nucleic acid binding  protein binding  nucleoplasm  nucleolus  cytoplasm  centrosome  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA processing  lyase activity  RNA phosphodiester bond hydrolysis  RNA phosphodiester bond hydrolysis, endonucleolytic  RNA phosphodiester bond hydrolysis, endonucleolytic  
NDEx NetworkTSEN2
Atlas of Cancer Signalling NetworkTSEN2
Wikipedia pathwaysTSEN2
Orthology - Evolution
OrthoDB80746
GeneTree (enSembl)ENSG00000154743
Phylogenetic Trees/Animal Genes : TreeFamTSEN2
HOVERGENQ8NCE0
HOGENOMQ8NCE0
Homologs : HomoloGeneTSEN2
Homology/Alignments : Family Browser (UCSC)TSEN2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSEN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSEN2
dbVarTSEN2
ClinVarTSEN2
1000_GenomesTSEN2 
Exome Variant ServerTSEN2
ExAC (Exome Aggregation Consortium)TSEN2 (select the gene name)
Genetic variants : HAPMAP80746
Genomic Variants (DGV)TSEN2 [DGVbeta]
DECIPHER (Syndromes)3:12526010-12574820  ENSG00000154743
CONAN: Copy Number AnalysisTSEN2 
Mutations
ICGC Data PortalTSEN2 
TCGA Data PortalTSEN2 
Broad Tumor PortalTSEN2
OASIS PortalTSEN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSEN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTSEN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TSEN2
DgiDB (Drug Gene Interaction Database)TSEN2
DoCM (Curated mutations)TSEN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TSEN2 (select a term)
intoGenTSEN2
Cancer3DTSEN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608753    612389   
Orphanet2334   
MedgenTSEN2
Genetic Testing Registry TSEN2
NextProtQ8NCE0 [Medical]
TSGene80746
GENETestsTSEN2
Huge Navigator TSEN2 [HugePedia]
snp3D : Map Gene to Disease80746
BioCentury BCIQTSEN2
ClinGenTSEN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80746
Chemical/Pharm GKB GenePA142670695
Clinical trialTSEN2
Miscellaneous
canSAR (ICR)TSEN2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTSEN2
EVEXTSEN2
GoPubMedTSEN2
iHOPTSEN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:49:56 CET 2017

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