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TSEN34 (tRNA splicing endonuclease subunit 34)

Identity

Alias (NCBI)LENG5
PCH2C
SEN34
SEN34L
HGNC (Hugo) TSEN34
HGNC Alias symbSEN34
SEN34L
HGNC Previous nameLENG5
HGNC Previous nameleukocyte receptor cluster (LRC) member 5
 tRNA splicing endonuclease 34 homolog (SEN34, S. cerevisiae)
 tRNA splicing endonuclease 34 homolog (S. cerevisiae)
 TSEN34 tRNA splicing endonuclease subunit
LocusID (NCBI) 79042
Atlas_Id 75223
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 54190344 and ends at 54194532 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TSEN34   15506
Cards
Entrez_Gene (NCBI)TSEN34    tRNA splicing endonuclease subunit 34
AliasesLENG5; PCH2C; SEN34; SEN34L
GeneCards (Weizmann)TSEN34
Ensembl hg19 (Hinxton)ENSG00000170892 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170892 [Gene_View]  ENSG00000170892 [Sequence]  chr19:54190344-54194532 [Contig_View]  TSEN34 [Vega]
ICGC DataPortalENSG00000170892
TCGA cBioPortalTSEN34
AceView (NCBI)TSEN34
Genatlas (Paris)TSEN34
SOURCE (Princeton)TSEN34
Genetics Home Reference (NIH)TSEN34
Genomic and cartography
GoldenPath hg38 (UCSC)TSEN34  -     chr19:54190344-54194532 +  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TSEN34  -     19q13.42   [Description]    (hg19-Feb_2009)
GoldenPathTSEN34 - 19q13.42 [CytoView hg19]  TSEN34 - 19q13.42 [CytoView hg38]
ImmunoBaseENSG00000170892
Genome Data Viewer NCBITSEN34 [Mapview hg19]  
OMIM608754   612390   
Gene and transcription
Genbank (Entrez)AF211970 AK025929 AK054944 AK225385 AK226013
RefSeq transcript (Entrez)NM_001077446 NM_001282332 NM_001282333 NM_001386740 NM_024075
Consensus coding sequences : CCDS (NCBI)TSEN34
Gene ExpressionTSEN34 [ NCBI-GEO ]   TSEN34 [ EBI - ARRAY_EXPRESS ]   TSEN34 [ SEEK ]   TSEN34 [ MEM ]
Gene Expression Viewer (FireBrowse)TSEN34 [ Firebrowse - Broad ]
GenevisibleExpression of TSEN34 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79042
GTEX Portal (Tissue expression)TSEN34
Human Protein AtlasENSG00000170892-TSEN34 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BSV6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BSV6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BSV6
Catalytic activity : Enzyme4.6.1.16 [ Enzyme-Expasy ]   4.6.1.164.6.1.16 [ IntEnz-EBI ]   4.6.1.16 [ BRENDA ]   4.6.1.16 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9BSV6
Domains : Interpro (EBI)tRNA_endonuc-like_dom_sf    tRNA_intron_Endo_cat-like_sf    tRNA_intron_Endonuc_cat-like    tRNA_splic    tRNA_splic_SEN34   
Domain families : Pfam (Sanger)tRNA_int_endo (PF01974)   
Domain families : Pfam (NCBI)pfam01974   
Conserved Domain (NCBI)TSEN34
SuperfamilyQ9BSV6
AlphaFold pdb e-kbQ9BSV6   
Human Protein Atlas [tissue]ENSG00000170892-TSEN34 [tissue]
HPRD10038
Protein Interaction databases
DIP (DOE-UCLA)Q9BSV6
IntAct (EBI)Q9BSV6
BioGRIDTSEN34
STRING (EMBL)TSEN34
ZODIACTSEN34
Ontologies - Pathways
QuickGOQ9BSV6
Ontology : AmiGOtRNA-intron endonuclease activity  tRNA-intron endonuclease complex  tRNA-type intron splice site recognition and cleavage  nucleic acid binding  nucleoplasm  nucleoplasm  nucleolus  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA processing  lyase activity  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBItRNA-intron endonuclease activity  tRNA-intron endonuclease complex  tRNA-type intron splice site recognition and cleavage  nucleic acid binding  nucleoplasm  nucleoplasm  nucleolus  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA processing  lyase activity  RNA phosphodiester bond hydrolysis, endonucleolytic  
NDEx NetworkTSEN34
Atlas of Cancer Signalling NetworkTSEN34
Wikipedia pathwaysTSEN34
Orthology - Evolution
OrthoDB79042
GeneTree (enSembl)ENSG00000170892
Phylogenetic Trees/Animal Genes : TreeFamTSEN34
Homologs : HomoloGeneTSEN34
Homology/Alignments : Family Browser (UCSC)TSEN34
Gene fusions - Rearrangements
Fusion : QuiverTSEN34
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSEN34 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSEN34
dbVarTSEN34
ClinVarTSEN34
MonarchTSEN34
1000_GenomesTSEN34 
Exome Variant ServerTSEN34
GNOMAD BrowserENSG00000170892
Varsome BrowserTSEN34
ACMGTSEN34 variants
VarityQ9BSV6
Genomic Variants (DGV)TSEN34 [DGVbeta]
DECIPHERTSEN34 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTSEN34 
Mutations
ICGC Data PortalTSEN34 
TCGA Data PortalTSEN34 
Broad Tumor PortalTSEN34
OASIS PortalTSEN34 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSEN34  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTSEN34
Mutations and Diseases : HGMDTSEN34
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTSEN34
DgiDB (Drug Gene Interaction Database)TSEN34
DoCM (Curated mutations)TSEN34
CIViC (Clinical Interpretations of Variants in Cancer)TSEN34
Cancer3DTSEN34
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608754    612390   
Orphanet2334   
DisGeNETTSEN34
MedgenTSEN34
Genetic Testing Registry TSEN34
NextProtQ9BSV6 [Medical]
GENETestsTSEN34
Target ValidationTSEN34
Huge Navigator TSEN34 [HugePedia]
ClinGenTSEN34
Clinical trials, drugs, therapy
MyCancerGenomeTSEN34
Protein Interactions : CTDTSEN34
Pharm GKB GenePA134871088
PharosQ9BSV6
Clinical trialTSEN34
Miscellaneous
canSAR (ICR)TSEN34
HarmonizomeTSEN34
DataMed IndexTSEN34
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTSEN34
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:27:07 CEST 2021

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