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TSEN34 (tRNA splicing endonuclease subunit 34)

Identity

Alias_namesLENG5
leukocyte receptor cluster (LRC) member 5
tRNA splicing endonuclease 34 homolog (SEN34, S. cerevisiae)
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
TSEN34 tRNA splicing endonuclease subunit
Alias_symbol (synonym)SEN34
SEN34L
Other aliasPCH2C
HGNC (Hugo) TSEN34
LocusID (NCBI) 79042
Atlas_Id 75223
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 54191214 and ends at 54194536 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TSEN34   15506
Cards
Entrez_Gene (NCBI)TSEN34  79042  tRNA splicing endonuclease subunit 34
AliasesLENG5; PCH2C; SEN34; SEN34L
GeneCards (Weizmann)TSEN34
Ensembl hg19 (Hinxton)ENSG00000170892 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170892 [Gene_View]  chr19:54191214-54194536 [Contig_View]  TSEN34 [Vega]
ICGC DataPortalENSG00000170892
TCGA cBioPortalTSEN34
AceView (NCBI)TSEN34
Genatlas (Paris)TSEN34
WikiGenes79042
SOURCE (Princeton)TSEN34
Genetics Home Reference (NIH)TSEN34
Genomic and cartography
GoldenPath hg38 (UCSC)TSEN34  -     chr19:54191214-54194536 +  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TSEN34  -     19q13.42   [Description]    (hg19-Feb_2009)
EnsemblTSEN34 - 19q13.42 [CytoView hg19]  TSEN34 - 19q13.42 [CytoView hg38]
Mapping of homologs : NCBITSEN34 [Mapview hg19]  TSEN34 [Mapview hg38]
OMIM608754   612390   
Gene and transcription
Genbank (Entrez)AF211970 AK025929 AK054944 AK225385 AK226013
RefSeq transcript (Entrez)NM_001077446 NM_001282332 NM_001282333 NM_024075
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_015810 NG_033045 NT_187693 NW_003571054 NW_003571055 NW_003571056 NW_003571057 NW_003571058 NW_003571059 NW_003571060 NW_003571061
Consensus coding sequences : CCDS (NCBI)TSEN34
Cluster EST : UnigeneHs.15580 [ NCBI ]
CGAP (NCI)Hs.15580
Alternative Splicing GalleryENSG00000170892
Gene ExpressionTSEN34 [ NCBI-GEO ]   TSEN34 [ EBI - ARRAY_EXPRESS ]   TSEN34 [ SEEK ]   TSEN34 [ MEM ]
Gene Expression Viewer (FireBrowse)TSEN34 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79042
GTEX Portal (Tissue expression)TSEN34
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BSV6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BSV6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BSV6
Splice isoforms : SwissVarQ9BSV6
Catalytic activity : Enzyme4.6.1.16 [ Enzyme-Expasy ]   4.6.1.164.6.1.16 [ IntEnz-EBI ]   4.6.1.16 [ BRENDA ]   4.6.1.16 [ KEGG ]   
PhosPhoSitePlusQ9BSV6
Domains : Interpro (EBI)tRNA_endonuc-like_dom    tRNA_intron_Endonuc_cat-like    tRNA_splic    tRNA_splic_SEN34   
Domain families : Pfam (Sanger)tRNA_int_endo (PF01974)   
Domain families : Pfam (NCBI)pfam01974   
Conserved Domain (NCBI)TSEN34
DMDM Disease mutations79042
Blocks (Seattle)TSEN34
SuperfamilyQ9BSV6
Human Protein AtlasENSG00000170892
Peptide AtlasQ9BSV6
HPRD10038
IPIIPI00940410   IPI00451941   IPI00657943   IPI00658061   IPI00894217   
Protein Interaction databases
DIP (DOE-UCLA)Q9BSV6
IntAct (EBI)Q9BSV6
FunCoupENSG00000170892
BioGRIDTSEN34
STRING (EMBL)TSEN34
ZODIACTSEN34
Ontologies - Pathways
QuickGOQ9BSV6
Ontology : AmiGOtRNA-intron endonuclease activity  tRNA-intron endonuclease complex  tRNA-type intron splice site recognition and cleavage  nucleus  nucleoplasm  nucleolus  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA processing  lyase activity  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBItRNA-intron endonuclease activity  tRNA-intron endonuclease complex  tRNA-type intron splice site recognition and cleavage  nucleus  nucleoplasm  nucleolus  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA processing  lyase activity  RNA phosphodiester bond hydrolysis, endonucleolytic  
NDEx NetworkTSEN34
Atlas of Cancer Signalling NetworkTSEN34
Wikipedia pathwaysTSEN34
Orthology - Evolution
OrthoDB79042
GeneTree (enSembl)ENSG00000170892
Phylogenetic Trees/Animal Genes : TreeFamTSEN34
HOVERGENQ9BSV6
HOGENOMQ9BSV6
Homologs : HomoloGeneTSEN34
Homology/Alignments : Family Browser (UCSC)TSEN34
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSEN34 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSEN34
dbVarTSEN34
ClinVarTSEN34
1000_GenomesTSEN34 
Exome Variant ServerTSEN34
ExAC (Exome Aggregation Consortium)TSEN34 (select the gene name)
Genetic variants : HAPMAP79042
Genomic Variants (DGV)TSEN34 [DGVbeta]
DECIPHERTSEN34 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTSEN34 
Mutations
ICGC Data PortalTSEN34 
TCGA Data PortalTSEN34 
Broad Tumor PortalTSEN34
OASIS PortalTSEN34 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSEN34  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTSEN34
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TSEN34
DgiDB (Drug Gene Interaction Database)TSEN34
DoCM (Curated mutations)TSEN34 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TSEN34 (select a term)
intoGenTSEN34
Cancer3DTSEN34(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608754    612390   
Orphanet2334   
MedgenTSEN34
Genetic Testing Registry TSEN34
NextProtQ9BSV6 [Medical]
TSGene79042
GENETestsTSEN34
Target ValidationTSEN34
Huge Navigator TSEN34 [HugePedia]
snp3D : Map Gene to Disease79042
BioCentury BCIQTSEN34
ClinGenTSEN34
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79042
Chemical/Pharm GKB GenePA134871088
Clinical trialTSEN34
Miscellaneous
canSAR (ICR)TSEN34 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTSEN34
EVEXTSEN34
GoPubMedTSEN34
iHOPTSEN34
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:42:41 CEST 2017

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