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TSEN54 (tRNA splicing endonuclease subunit 54)

Identity

Alias (NCBI)PCH2A
PCH4
PCH5
SEN54L
sen54
HGNC (Hugo) TSEN54
HGNC Alias symbSEN54
SEN54L
HGNC Previous nametRNA splicing endonuclease 54 homolog (SEN54, S. cerevisiae)
 tRNA splicing endonuclease 54 homolog (S. cerevisiae)
 TSEN54 tRNA splicing endonuclease subunit
LocusID (NCBI) 283989
Atlas_Id 75224
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 75516528 and ends at 75524735 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EIF3G (19p13.2) / TSEN54 (17q25.1)TSEN54 (17q25.1) / C11orf49 (11p11.2)TSEN54 (17q25.1) / TSEN54 (17q25.1)
WWP2 (16q22.1) / TSEN54 (17q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TSEN54   27561
Cards
Entrez_Gene (NCBI)TSEN54    tRNA splicing endonuclease subunit 54
AliasesPCH2A; PCH4; PCH5; SEN54L; 
sen54
GeneCards (Weizmann)TSEN54
Ensembl hg19 (Hinxton)ENSG00000182173 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182173 [Gene_View]  ENSG00000182173 [Sequence]  chr17:75516528-75524735 [Contig_View]  TSEN54 [Vega]
ICGC DataPortalENSG00000182173
TCGA cBioPortalTSEN54
AceView (NCBI)TSEN54
Genatlas (Paris)TSEN54
SOURCE (Princeton)TSEN54
Genetics Home Reference (NIH)TSEN54
Genomic and cartography
GoldenPath hg38 (UCSC)TSEN54  -     chr17:75516528-75524735 +  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TSEN54  -     17q25.1   [Description]    (hg19-Feb_2009)
GoldenPathTSEN54 - 17q25.1 [CytoView hg19]  TSEN54 - 17q25.1 [CytoView hg38]
ImmunoBaseENSG00000182173
Genome Data Viewer NCBITSEN54 [Mapview hg19]  
OMIM225753   277470   608755   610204   
Gene and transcription
Genbank (Entrez)AK094466 AK097583 BC045551 BC047793 BC053643
RefSeq transcript (Entrez)NM_207346
Consensus coding sequences : CCDS (NCBI)TSEN54
Gene ExpressionTSEN54 [ NCBI-GEO ]   TSEN54 [ EBI - ARRAY_EXPRESS ]   TSEN54 [ SEEK ]   TSEN54 [ MEM ]
Gene Expression Viewer (FireBrowse)TSEN54 [ Firebrowse - Broad ]
GenevisibleExpression of TSEN54 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)283989
GTEX Portal (Tissue expression)TSEN54
Human Protein AtlasENSG00000182173-TSEN54 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z6J9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z6J9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z6J9
PhosPhoSitePlusQ7Z6J9
Domains : Interpro (EBI)tRNA_splic_suSen54    tRNA_splic_suSen54_N   
Domain families : Pfam (Sanger)tRNA_int_end_N2 (PF12928)   
Domain families : Pfam (NCBI)pfam12928   
Conserved Domain (NCBI)TSEN54
SuperfamilyQ7Z6J9
AlphaFold pdb e-kbQ7Z6J9   
Human Protein Atlas [tissue]ENSG00000182173-TSEN54 [tissue]
HPRD12291
Protein Interaction databases
DIP (DOE-UCLA)Q7Z6J9
IntAct (EBI)Q7Z6J9
BioGRIDTSEN54
STRING (EMBL)TSEN54
ZODIACTSEN54
Ontologies - Pathways
QuickGOQ7Z6J9
Ontology : AmiGOtRNA-intron endonuclease complex  tRNA-type intron splice site recognition and cleavage  protein binding  nucleoplasm  nucleolus  tRNA splicing, via endonucleolytic cleavage and ligation  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA processing  
Ontology : EGO-EBItRNA-intron endonuclease complex  tRNA-type intron splice site recognition and cleavage  protein binding  nucleoplasm  nucleolus  tRNA splicing, via endonucleolytic cleavage and ligation  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA processing  
NDEx NetworkTSEN54
Atlas of Cancer Signalling NetworkTSEN54
Wikipedia pathwaysTSEN54
Orthology - Evolution
OrthoDB283989
GeneTree (enSembl)ENSG00000182173
Phylogenetic Trees/Animal Genes : TreeFamTSEN54
Homologs : HomoloGeneTSEN54
Homology/Alignments : Family Browser (UCSC)TSEN54
Gene fusions - Rearrangements
Fusion : QuiverTSEN54
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSEN54 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSEN54
dbVarTSEN54
ClinVarTSEN54
MonarchTSEN54
1000_GenomesTSEN54 
Exome Variant ServerTSEN54
GNOMAD BrowserENSG00000182173
Varsome BrowserTSEN54
ACMGTSEN54 variants
VarityQ7Z6J9
Genomic Variants (DGV)TSEN54 [DGVbeta]
DECIPHERTSEN54 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTSEN54 
Mutations
ICGC Data PortalTSEN54 
TCGA Data PortalTSEN54 
Broad Tumor PortalTSEN54
OASIS PortalTSEN54 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSEN54  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTSEN54
Mutations and Diseases : HGMDTSEN54
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTSEN54
DgiDB (Drug Gene Interaction Database)TSEN54
DoCM (Curated mutations)TSEN54
CIViC (Clinical Interpretations of Variants in Cancer)TSEN54
Cancer3DTSEN54
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM225753    277470    608755    610204   
Orphanet17609    17608    2334    3132   
DisGeNETTSEN54
MedgenTSEN54
Genetic Testing Registry TSEN54
NextProtQ7Z6J9 [Medical]
GENETestsTSEN54
Target ValidationTSEN54
Huge Navigator TSEN54 [HugePedia]
ClinGenTSEN54
Clinical trials, drugs, therapy
MyCancerGenomeTSEN54
Protein Interactions : CTDTSEN54
Pharm GKB GenePA142670692
PharosQ7Z6J9
Clinical trialTSEN54
Miscellaneous
canSAR (ICR)TSEN54
HarmonizomeTSEN54
DataMed IndexTSEN54
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTSEN54
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:27:07 CEST 2021

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