Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TSEN54 (tRNA splicing endonuclease subunit 54)

Identity

Alias_namestRNA splicing endonuclease 54 homolog (SEN54, S. cerevisiae)
tRNA splicing endonuclease 54 homolog (S. cerevisiae)
TSEN54 tRNA splicing endonuclease subunit
Alias_symbol (synonym)SEN54
SEN54L
Other aliasPCH2A
PCH4
PCH5
sen54
HGNC (Hugo) TSEN54
LocusID (NCBI) 283989
Atlas_Id 75224
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 75516528 and ends at 75524739 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EIF3G (19p13.2) / TSEN54 (17q25.1)TSEN54 (17q25.1) / C11orf49 (11p11.2)TSEN54 (17q25.1) / TSEN54 (17q25.1)
WWP2 (16q22.1) / TSEN54 (17q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TSEN54   27561
Cards
Entrez_Gene (NCBI)TSEN54  283989  tRNA splicing endonuclease subunit 54
AliasesPCH2A; PCH4; PCH5; SEN54L; 
sen54
GeneCards (Weizmann)TSEN54
Ensembl hg19 (Hinxton)ENSG00000182173 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182173 [Gene_View]  chr17:75516528-75524739 [Contig_View]  TSEN54 [Vega]
ICGC DataPortalENSG00000182173
TCGA cBioPortalTSEN54
AceView (NCBI)TSEN54
Genatlas (Paris)TSEN54
WikiGenes283989
SOURCE (Princeton)TSEN54
Genetics Home Reference (NIH)TSEN54
Genomic and cartography
GoldenPath hg38 (UCSC)TSEN54  -     chr17:75516528-75524739 +  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TSEN54  -     17q25.1   [Description]    (hg19-Feb_2009)
EnsemblTSEN54 - 17q25.1 [CytoView hg19]  TSEN54 - 17q25.1 [CytoView hg38]
Mapping of homologs : NCBITSEN54 [Mapview hg19]  TSEN54 [Mapview hg38]
OMIM225753   277470   608755   
Gene and transcription
Genbank (Entrez)AK094466 AK097583 BC045551 BC047793 BC053643
RefSeq transcript (Entrez)NM_207346
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TSEN54
Cluster EST : UnigeneHs.378501 [ NCBI ]
CGAP (NCI)Hs.378501
Alternative Splicing GalleryENSG00000182173
Gene ExpressionTSEN54 [ NCBI-GEO ]   TSEN54 [ EBI - ARRAY_EXPRESS ]   TSEN54 [ SEEK ]   TSEN54 [ MEM ]
Gene Expression Viewer (FireBrowse)TSEN54 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)283989
GTEX Portal (Tissue expression)TSEN54
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z6J9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z6J9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z6J9
Splice isoforms : SwissVarQ7Z6J9
PhosPhoSitePlusQ7Z6J9
Domains : Interpro (EBI)tRNA_splic_suSen54    tRNA_splic_suSen54_N   
Domain families : Pfam (Sanger)tRNA_int_end_N2 (PF12928)   
Domain families : Pfam (NCBI)pfam12928   
Conserved Domain (NCBI)TSEN54
DMDM Disease mutations283989
Blocks (Seattle)TSEN54
SuperfamilyQ7Z6J9
Human Protein AtlasENSG00000182173
Peptide AtlasQ7Z6J9
HPRD12291
IPIIPI00329143   IPI00429119   IPI00902460   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z6J9
IntAct (EBI)Q7Z6J9
FunCoupENSG00000182173
BioGRIDTSEN54
STRING (EMBL)TSEN54
ZODIACTSEN54
Ontologies - Pathways
QuickGOQ7Z6J9
Ontology : AmiGOtRNA-intron endonuclease activity  tRNA-intron endonuclease complex  tRNA-type intron splice site recognition and cleavage  protein binding  nucleoplasm  nucleolus  tRNA splicing, via endonucleolytic cleavage and ligation  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA processing  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBItRNA-intron endonuclease activity  tRNA-intron endonuclease complex  tRNA-type intron splice site recognition and cleavage  protein binding  nucleoplasm  nucleolus  tRNA splicing, via endonucleolytic cleavage and ligation  tRNA splicing, via endonucleolytic cleavage and ligation  mRNA processing  RNA phosphodiester bond hydrolysis, endonucleolytic  
NDEx NetworkTSEN54
Atlas of Cancer Signalling NetworkTSEN54
Wikipedia pathwaysTSEN54
Orthology - Evolution
OrthoDB283989
GeneTree (enSembl)ENSG00000182173
Phylogenetic Trees/Animal Genes : TreeFamTSEN54
HOVERGENQ7Z6J9
HOGENOMQ7Z6J9
Homologs : HomoloGeneTSEN54
Homology/Alignments : Family Browser (UCSC)TSEN54
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSEN54 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSEN54
dbVarTSEN54
ClinVarTSEN54
1000_GenomesTSEN54 
Exome Variant ServerTSEN54
ExAC (Exome Aggregation Consortium)TSEN54 (select the gene name)
Genetic variants : HAPMAP283989
Genomic Variants (DGV)TSEN54 [DGVbeta]
DECIPHERTSEN54 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTSEN54 
Mutations
ICGC Data PortalTSEN54 
TCGA Data PortalTSEN54 
Broad Tumor PortalTSEN54
OASIS PortalTSEN54 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSEN54  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTSEN54
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TSEN54
DgiDB (Drug Gene Interaction Database)TSEN54
DoCM (Curated mutations)TSEN54 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TSEN54 (select a term)
intoGenTSEN54
Cancer3DTSEN54(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM225753    277470    608755   
Orphanet17609    17608    2334    3132   
MedgenTSEN54
Genetic Testing Registry TSEN54
NextProtQ7Z6J9 [Medical]
TSGene283989
GENETestsTSEN54
Target ValidationTSEN54
Huge Navigator TSEN54 [HugePedia]
snp3D : Map Gene to Disease283989
BioCentury BCIQTSEN54
ClinGenTSEN54
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD283989
Chemical/Pharm GKB GenePA142670692
Clinical trialTSEN54
Miscellaneous
canSAR (ICR)TSEN54 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTSEN54
EVEXTSEN54
GoPubMedTSEN54
iHOPTSEN54
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:42:41 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.