Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TSG101 (tumor susceptibility 101)

Identity

Other namesTSG10
VPS23
HGNC (Hugo) TSG101
LocusID (NCBI) 7251
Atlas_Id 42712
Location 11p15.1
Location_base_pair Starts at 18501858 and ends at 18548503 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NPIPB7 (16q23.1) / TSG101 (11p15.1)TSG101 (11p15.1) / C10orf11 (10q22.2)TSG101 (11p15.1) / SLC20A1 (2q13)
TSG101 (11p15.1) / YWHAB (20q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(11)(q23q23) KMT2A/CBL;t(11;11)(q23;q23) KMT2A/CBL

External links

Nomenclature
HGNC (Hugo)TSG101   15971
Cards
Entrez_Gene (NCBI)TSG101  7251  tumor susceptibility 101
GeneCards (Weizmann)TSG101
Ensembl hg19 (Hinxton)ENSG00000074319 [Gene_View]  chr11:18501858-18548503 [Contig_View]  TSG101 [Vega]
Ensembl hg38 (Hinxton)ENSG00000074319 [Gene_View]  chr11:18501858-18548503 [Contig_View]  TSG101 [Vega]
ICGC DataPortalENSG00000074319
TCGA cBioPortalTSG101
AceView (NCBI)TSG101
Genatlas (Paris)TSG101
WikiGenes7251
SOURCE (Princeton)TSG101
Genomic and cartography
GoldenPath hg19 (UCSC)TSG101  -     chr11:18501858-18548503 -  11p15.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TSG101  -     11p15.1   [Description]    (hg38-Dec_2013)
EnsemblTSG101 - 11p15.1 [CytoView hg19]  TSG101 - 11p15.1 [CytoView hg38]
Mapping of homologs : NCBITSG101 [Mapview hg19]  TSG101 [Mapview hg38]
OMIM114480   601387   
Gene and transcription
Genbank (Entrez)AK130787 AU138453 AY207473 AY207474 BC002487
RefSeq transcript (Entrez)NM_006292
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_012138 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)TSG101
Cluster EST : UnigeneHs.523512 [ NCBI ]
CGAP (NCI)Hs.523512
Alternative Splicing : Fast-db (Paris)GSHG0005633
Alternative Splicing GalleryENSG00000074319
Gene ExpressionTSG101 [ NCBI-GEO ]   TSG101 [ EBI - ARRAY_EXPRESS ]   TSG101 [ SEEK ]   TSG101 [ MEM ]
Gene Expression Viewer (FireBrowse)TSG101 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)7251
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99816 (Uniprot)
NextProtQ99816  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99816
Splice isoforms : SwissVarQ99816 (Swissvar)
PhosPhoSitePlusQ99816
Domaine pattern : Prosite (Expaxy)SB (PS51312)    UEV (PS51322)   
Domains : Interpro (EBI)SB_dom    UBQ-conjugating_enzyme/RWD    UEV_N   
Domain families : Pfam (Sanger)UEV (PF05743)    Vps23_core (PF09454)   
Domain families : Pfam (NCBI)pfam05743    pfam09454   
DMDM Disease mutations7251
Blocks (Seattle)TSG101
PDB (SRS)1KPP    1KPQ    1M4P    1M4Q    1S1Q    2F0R    3IV1    3OBQ    3OBS    3OBU    3OBX    3P9G    3P9H    4EJE   
PDB (PDBSum)1KPP    1KPQ    1M4P    1M4Q    1S1Q    2F0R    3IV1    3OBQ    3OBS    3OBU    3OBX    3P9G    3P9H    4EJE   
PDB (IMB)1KPP    1KPQ    1M4P    1M4Q    1S1Q    2F0R    3IV1    3OBQ    3OBS    3OBU    3OBX    3P9G    3P9H    4EJE   
PDB (RSDB)1KPP    1KPQ    1M4P    1M4Q    1S1Q    2F0R    3IV1    3OBQ    3OBS    3OBU    3OBX    3P9G    3P9H    4EJE   
Structural Biology KnowledgeBase1KPP    1KPQ    1M4P    1M4Q    1S1Q    2F0R    3IV1    3OBQ    3OBS    3OBU    3OBX    3P9G    3P9H    4EJE   
SCOP (Structural Classification of Proteins)1KPP    1KPQ    1M4P    1M4Q    1S1Q    2F0R    3IV1    3OBQ    3OBS    3OBU    3OBX    3P9G    3P9H    4EJE   
CATH (Classification of proteins structures)1KPP    1KPQ    1M4P    1M4Q    1S1Q    2F0R    3IV1    3OBQ    3OBS    3OBU    3OBX    3P9G    3P9H    4EJE   
SuperfamilyQ99816
Human Protein AtlasENSG00000074319
Peptide AtlasQ99816
HPRD03229
IPIIPI00018434   IPI00219826   IPI00383946   IPI01014105   
Protein Interaction databases
DIP (DOE-UCLA)Q99816
IntAct (EBI)Q99816
FunCoupENSG00000074319
BioGRIDTSG101
STRING (EMBL)TSG101
ZODIACTSG101
Ontologies - Pathways
QuickGOQ99816
Ontology : AmiGOESCRT I complex  ESCRT I complex  regulation of cell growth  DNA binding  transcription corepressor activity  protein binding  nucleolus  cytoplasm  cytoplasm  endosome  early endosome  late endosome  multivesicular body  plasma membrane  protein monoubiquitination  autophagy  cell cycle arrest  negative regulation of cell proliferation  endosome to lysosome transport  endosome membrane  protein transport  endosomal transport  viral life cycle  keratinocyte differentiation  ligand-dependent nuclear receptor transcription coactivator activity  ubiquitin protein ligase binding  late endosome membrane  multivesicular body assembly  viral budding via host ESCRT complex  protein homodimerization activity  ubiquitin binding  ubiquitin binding  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  regulation of MAP kinase activity  negative regulation of transcription, DNA-templated  viral budding  viral budding  virion binding  calcium-dependent protein binding  positive regulation of viral process  cell division  extracellular exosome  intracellular transport of virus  autophagosome maturation  regulation of viral release from host cell  positive regulation of viral release from host cell  positive regulation of exosomal secretion  regulation of extracellular exosome assembly  regulation of viral budding via host ESCRT complex  positive regulation of viral budding via host ESCRT complex  positive regulation of ubiquitin-dependent endocytosis  
Ontology : EGO-EBIESCRT I complex  ESCRT I complex  regulation of cell growth  DNA binding  transcription corepressor activity  protein binding  nucleolus  cytoplasm  cytoplasm  endosome  early endosome  late endosome  multivesicular body  plasma membrane  protein monoubiquitination  autophagy  cell cycle arrest  negative regulation of cell proliferation  endosome to lysosome transport  endosome membrane  protein transport  endosomal transport  viral life cycle  keratinocyte differentiation  ligand-dependent nuclear receptor transcription coactivator activity  ubiquitin protein ligase binding  late endosome membrane  multivesicular body assembly  viral budding via host ESCRT complex  protein homodimerization activity  ubiquitin binding  ubiquitin binding  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  regulation of MAP kinase activity  negative regulation of transcription, DNA-templated  viral budding  viral budding  virion binding  calcium-dependent protein binding  positive regulation of viral process  cell division  extracellular exosome  intracellular transport of virus  autophagosome maturation  regulation of viral release from host cell  positive regulation of viral release from host cell  positive regulation of exosomal secretion  regulation of extracellular exosome assembly  regulation of viral budding via host ESCRT complex  positive regulation of viral budding via host ESCRT complex  positive regulation of ubiquitin-dependent endocytosis  
Pathways : BIOCARTAStathmin and breast cancer resistance to antimicrotubule agents [Genes]   
Pathways : KEGGEndocytosis   
NDEx Network
Atlas of Cancer Signalling NetworkTSG101
Wikipedia pathwaysTSG101
Orthology - Evolution
OrthoDB7251
GeneTree (enSembl)ENSG00000074319
Phylogenetic Trees/Animal Genes : TreeFamTSG101
Homologs : HomoloGeneTSG101
Homology/Alignments : Family Browser (UCSC)TSG101
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTSG101 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSG101
dbVarTSG101
ClinVarTSG101
1000_GenomesTSG101 
Exome Variant ServerTSG101
ExAC (Exome Aggregation Consortium)TSG101 (select the gene name)
SNP (GeneSNP Utah)TSG101
SNP : HGBaseTSG101
Genetic variants : HAPMAPTSG101
Genomic Variants (DGV)TSG101 [DGVbeta]
Mutations
ICGC Data PortalTSG101 
TCGA Data PortalTSG101 
Broad Tumor PortalTSG101
OASIS PortalTSG101 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSG101 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TSG101
DgiDB (Drug Gene Interaction Database)TSG101
DoCM (Curated mutations)TSG101 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TSG101 (select a term)
intoGenTSG101
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:18501858-18548503
CONAN: Copy Number AnalysisTSG101 
Mutations and Diseases : HGMDTSG101
OMIM114480    601387   
MedgenTSG101
Genetic Testing Registry TSG101
NextProtQ99816 [Medical]
TSGene7251
GENETestsTSG101
Huge Navigator TSG101 [HugePedia]  TSG101 [HugeCancerGEM]
snp3D : Map Gene to Disease7251
BioCentury BCIQTSG101
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7251
Chemical/Pharm GKB GenePA38068
Clinical trialTSG101
Miscellaneous
canSAR (ICR)TSG101 (select the gene name)
Probes
Litterature
PubMed249 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTSG101
GoPubMedTSG101
iHOPTSG101
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 18:08:35 CEST 2016

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