TSG101 (tumor susceptibility 101)

2003-02-01  

Identity

HGNC
LOCATION
11p15.1
LOCUSID
ALIAS
TSG10,VPS23
FUSION GENES

Other Information

Locus ID:

NCBI: 7251
MIM: 601387
HGNC: 15971
Ensembl: ENSG00000074319

Variants:

dbSNP: 7251
ClinVar: 7251
TCGA: ENSG00000074319
COSMIC: TSG101

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074319ENST00000251968Q99816
ENSG00000074319ENST00000536719F5H442
ENSG00000074319ENST00000580814J3QRU6
ENSG00000074319ENST00000584526J3QKS4

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
ESCRT-I complexKEGGhsa_M00409
ESCRT-I complexKEGGM00409
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Assembly Of The HIV VirionREACTOMER-HSA-175474
Synthesis And Processing Of GAG, GAGPOL PolyproteinsREACTOMER-HSA-174495
Membrane binding and targetting of GAG proteinsREACTOMER-HSA-174490
Budding and maturation of HIV virionREACTOMER-HSA-162588
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)REACTOMER-HSA-917729

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
175565482007Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery.304
178538932007Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.285
162567442005Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth.118
123798432002Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein.108
128020202003TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.102
120064922002Structure and functional interactions of the Tsg101 UEV domain.99
167075692006Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation.99
119169812002Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates.98
174288612007Potent rescue of human immunodeficiency virus type 1 late domain mutants by ALIX/AIP1 depends on its CHMP4 binding site.87
192829832009The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding.87

Citation

Dessen P

TSG101 (tumor susceptibility 101)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42712/tsg101