Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TSHZ2 (teashirt zinc finger homeobox 2)

Identity

Alias_namesC20orf17
ZNF218
chromosome 20 open reading frame 17
zinc finger protein 218
teashirt family zinc finger 2
Alias_symbol (synonym)ZABC2
OVC10-2
TSH2
Other alias
HGNC (Hugo) TSHZ2
LocusID (NCBI) 128553
Atlas_Id 52293
Location 20q13.2  [Link to chromosome band 20q13]
Location_base_pair Starts at 53185283 and ends at 53495330 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARFGEF2 (20q13.13) / TSHZ2 (20q13.2)ITCH (20q11.22) / TSHZ2 (20q13.2)OSBPL8 (12q21.2) / TSHZ2 (20q13.2)
PEX26 (22q11.21) / TSHZ2 (20q13.2)SDC4 (20q13.12) / TSHZ2 (20q13.2)STK4 (20q13.12) / TSHZ2 (20q13.2)
TAF4 (20q13.33) / TSHZ2 (20q13.2)TSHZ2 (20q13.2) / TSHZ2 (20q13.2)TSHZ2 (20q13.2) / ZRANB3 (2q21.3)
UAP1 (1q23.3) / TSHZ2 (20q13.2)USP35 (11q14.1) / TSHZ2 (20q13.2)ARFGEF2 20q13.13 / TSHZ2 20q13.2
ITCH 20q11.22 / TSHZ2 20q13.2OSBPL8 12q21.2 / TSHZ2 20q13.2SDC4 20q13.12 / TSHZ2 20q13.2
STK4 20q13.12 / TSHZ2 20q13.2TAF4 20q13.33 / TSHZ2 20q13.2UAP1 1q23.3 / TSHZ2 20q13.2
USP35 11q14.1 / TSHZ2 20q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TSHZ2   13010
Cards
Entrez_Gene (NCBI)TSHZ2  128553  teashirt zinc finger homeobox 2
AliasesC20orf17; OVC10-2; TSH2; ZABC2; 
ZNF218
GeneCards (Weizmann)TSHZ2
Ensembl hg19 (Hinxton)ENSG00000182463 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182463 [Gene_View]  chr20:53185283-53495330 [Contig_View]  TSHZ2 [Vega]
ICGC DataPortalENSG00000182463
TCGA cBioPortalTSHZ2
AceView (NCBI)TSHZ2
Genatlas (Paris)TSHZ2
WikiGenes128553
SOURCE (Princeton)TSHZ2
Genetics Home Reference (NIH)TSHZ2
Genomic and cartography
GoldenPath hg38 (UCSC)TSHZ2  -     chr20:53185283-53495330 +  20q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TSHZ2  -     20q13.2   [Description]    (hg19-Feb_2009)
EnsemblTSHZ2 - 20q13.2 [CytoView hg19]  TSHZ2 - 20q13.2 [CytoView hg38]
Mapping of homologs : NCBITSHZ2 [Mapview hg19]  TSHZ2 [Mapview hg38]
OMIM614118   
Gene and transcription
Genbank (Entrez)AF230201 AK091206 AK302570 AY926481 BC160051
RefSeq transcript (Entrez)NM_001193421 NM_173485
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TSHZ2
Cluster EST : UnigeneHs.473117 [ NCBI ]
CGAP (NCI)Hs.473117
Alternative Splicing GalleryENSG00000182463
Gene ExpressionTSHZ2 [ NCBI-GEO ]   TSHZ2 [ EBI - ARRAY_EXPRESS ]   TSHZ2 [ SEEK ]   TSHZ2 [ MEM ]
Gene Expression Viewer (FireBrowse)TSHZ2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)128553
GTEX Portal (Tissue expression)TSHZ2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRE2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRE2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRE2
Splice isoforms : SwissVarQ9NRE2
PhosPhoSitePlusQ9NRE2
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Homeobox_dom    Teashirt_fam    Tshz2    Znf_C2H2    Znf_C2H2-like   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)HOX (SM00389)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)TSHZ2
DMDM Disease mutations128553
Blocks (Seattle)TSHZ2
SuperfamilyQ9NRE2
Human Protein AtlasENSG00000182463
Peptide AtlasQ9NRE2
HPRD10730
IPIIPI00032988   IPI00796998   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRE2
IntAct (EBI)Q9NRE2
FunCoupENSG00000182463
BioGRIDTSHZ2
STRING (EMBL)TSHZ2
ZODIACTSHZ2
Ontologies - Pathways
QuickGOQ9NRE2
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  DNA binding  chromatin binding  protein binding  nucleus  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  multicellular organism development  metal ion binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  DNA binding  chromatin binding  protein binding  nucleus  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  multicellular organism development  metal ion binding  
NDEx NetworkTSHZ2
Atlas of Cancer Signalling NetworkTSHZ2
Wikipedia pathwaysTSHZ2
Orthology - Evolution
OrthoDB128553
GeneTree (enSembl)ENSG00000182463
Phylogenetic Trees/Animal Genes : TreeFamTSHZ2
HOVERGENQ9NRE2
HOGENOMQ9NRE2
Homologs : HomoloGeneTSHZ2
Homology/Alignments : Family Browser (UCSC)TSHZ2
Gene fusions - Rearrangements
Fusion : MitelmanARFGEF2/TSHZ2 [20q13.13/20q13.2]  [t(20;20)(q13;q13)]  
Fusion : MitelmanITCH/TSHZ2 [20q11.22/20q13.2]  [t(20;20)(q11;q13)]  
Fusion : MitelmanOSBPL8/TSHZ2 [12q21.2/20q13.2]  [t(12;20)(q21;q13)]  
Fusion : MitelmanSDC4/TSHZ2 [20q13.12/20q13.2]  [t(20;20)(q12;q13)]  
Fusion : MitelmanSTK4/TSHZ2 [20q13.12/20q13.2]  [t(20;20)(q13;q13)]  
Fusion : MitelmanTAF4/TSHZ2 [20q13.33/20q13.2]  [t(20;20)(q13;q13)]  
Fusion : MitelmanUAP1/TSHZ2 [1q23.3/20q13.2]  [t(1;20)(q23;q13)]  
Fusion : MitelmanUSP35/TSHZ2 [11q14.1/20q13.2]  [t(11;20)(q14;q13)]  
Fusion: TCGAARFGEF2 20q13.13 TSHZ2 20q13.2 BRCA
Fusion: TCGAITCH 20q11.22 TSHZ2 20q13.2 LUAD
Fusion: TCGAOSBPL8 12q21.2 TSHZ2 20q13.2 BRCA
Fusion: TCGASDC4 20q13.12 TSHZ2 20q13.2 LUAD
Fusion: TCGASTK4 20q13.12 TSHZ2 20q13.2 BRCA
Fusion: TCGATAF4 20q13.33 TSHZ2 20q13.2 LUAD
Fusion: TCGAUAP1 1q23.3 TSHZ2 20q13.2 BRCA
Fusion: TCGAUSP35 11q14.1 TSHZ2 20q13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSHZ2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSHZ2
dbVarTSHZ2
ClinVarTSHZ2
1000_GenomesTSHZ2 
Exome Variant ServerTSHZ2
ExAC (Exome Aggregation Consortium)TSHZ2 (select the gene name)
Genetic variants : HAPMAP128553
Genomic Variants (DGV)TSHZ2 [DGVbeta]
DECIPHERTSHZ2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTSHZ2 
Mutations
ICGC Data PortalTSHZ2 
TCGA Data PortalTSHZ2 
Broad Tumor PortalTSHZ2
OASIS PortalTSHZ2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSHZ2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTSHZ2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TSHZ2
DgiDB (Drug Gene Interaction Database)TSHZ2
DoCM (Curated mutations)TSHZ2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TSHZ2 (select a term)
intoGenTSHZ2
Cancer3DTSHZ2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614118   
Orphanet
MedgenTSHZ2
Genetic Testing Registry TSHZ2
NextProtQ9NRE2 [Medical]
TSGene128553
GENETestsTSHZ2
Target ValidationTSHZ2
Huge Navigator TSHZ2 [HugePedia]
snp3D : Map Gene to Disease128553
BioCentury BCIQTSHZ2
ClinGenTSHZ2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD128553
Chemical/Pharm GKB GenePA37589
Clinical trialTSHZ2
Miscellaneous
canSAR (ICR)TSHZ2 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTSHZ2
EVEXTSHZ2
GoPubMedTSHZ2
iHOPTSHZ2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 13:01:06 CEST 2017

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