TSHZ2 (teashirt zinc finger homeobox 2)

2011-07-01  

Identity

HGNC
TSHZ2
LOCATION
20q13.2
LOCUSID
128553
ALIAS
C20orf17,OVC10-2,TSH2,ZABC2,ZNF218
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 128553
MIM: 614118
HGNC: 13010
Ensembl: ENSG00000182463

Variants:

dbSNP: 128553
ClinVar: 128553
TCGA: ENSG00000182463
COSMIC: TSHZ2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182463ENST00000329613Q9NRE2
ENSG00000182463ENST00000371497Q9NRE2
ENSG00000182463ENST00000603338Q9NRE2
ENSG00000182463ENST00000605656S4R3C8
ENSG00000182463ENST00000626626B1H0U8

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166120929severe cutaneous adverse reactionsDiseaseVariantAnnotationassociatedPD29193002
PA448320allopurinolChemicalVariantAnnotationassociatedPD29193002

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
214237952011Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and prostate cancers.16
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
197451062010Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction.8
197451062010Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction.8
267443172016Down-regulation of the zinc-finger homeobox protein TSHZ2 releases GLI1 from the nuclear repressor complex to restore its transcriptional activity during mammary tumorigenesis.7

Citation

Dessen P

TSHZ2 (teashirt zinc finger homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52293/tshz2