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TSN (translin)

Identity

Alias (NCBI)BCLF-1
C3PO
RCHF1
REHF-1
TBRBP
TRSLN
HGNC (Hugo) TSN
HGNC Alias symbTRSLN
BCLF-1
REHF-1
HGNC Alias namerecombination hotspot associated factor
LocusID (NCBI) 7247
Atlas_Id 42715
Location 2q14.3  [Link to chromosome band 2q14]
Location_base_pair Starts at 121755651 and ends at 121767852 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARL4D (17q21.31) / TSN (2q14.3)JMJD1C (10q21.3) / TSN (2q14.3)LOC100505718 () / TSN (2q14.3)
RNF214 (11q23.3) / TSN (2q14.3)SPAG9 (17q21.33) / TSN (2q14.3)TMPRSS11B (4q13.2) / TSN (2q14.3)
TSN (2q14.3) / ARL4D (17q21.31)TSN (2q14.3) / TSN (2q14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;10)(q14;q21) JMJD1C/TSN


External links

 

Nomenclature
HGNC (Hugo)TSN   12379
Cards
Entrez_Gene (NCBI)TSN    translin
AliasesBCLF-1; C3PO; RCHF1; REHF-1; 
TBRBP; TRSLN
GeneCards (Weizmann)TSN
Ensembl hg19 (Hinxton)ENSG00000211460 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000211460 [Gene_View]  ENSG00000211460 [Sequence]  chr2:121755651-121767852 [Contig_View]  TSN [Vega]
ICGC DataPortalENSG00000211460
TCGA cBioPortalTSN
AceView (NCBI)TSN
Genatlas (Paris)TSN
SOURCE (Princeton)TSN
Genetics Home Reference (NIH)TSN
Genomic and cartography
GoldenPath hg38 (UCSC)TSN  -     chr2:121755651-121767852 +  2q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TSN  -     2q14.3   [Description]    (hg19-Feb_2009)
GoldenPathTSN - 2q14.3 [CytoView hg19]  TSN - 2q14.3 [CytoView hg38]
ImmunoBaseENSG00000211460
Genome Data Viewer NCBITSN [Mapview hg19]  
OMIM600575   
Gene and transcription
Genbank (Entrez)AK091915 AK222868 AK296469 AK298812 AK307344
RefSeq transcript (Entrez)NM_001261401 NM_004622
Consensus coding sequences : CCDS (NCBI)TSN
Gene ExpressionTSN [ NCBI-GEO ]   TSN [ EBI - ARRAY_EXPRESS ]   TSN [ SEEK ]   TSN [ MEM ]
Gene Expression Viewer (FireBrowse)TSN [ Firebrowse - Broad ]
GenevisibleExpression of TSN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7247
GTEX Portal (Tissue expression)TSN
Human Protein AtlasENSG00000211460-TSN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15631   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15631  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15631
Catalytic activity : Enzyme3.1.-.- [ Enzyme-Expasy ]   3.1.-.-3.1.-.- [ IntEnz-EBI ]   3.1.-.- [ BRENDA ]   3.1.-.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ15631
Domains : Interpro (EBI)Translin    Translin_C    Translin_fam    Translin_N    Translin_sf   
Domain families : Pfam (Sanger)Translin (PF01997)   
Domain families : Pfam (NCBI)pfam01997   
Conserved Domain (NCBI)TSN
PDB (RSDB)1J1J    3PJA    3QB5    4WYV   
PDB Europe1J1J    3PJA    3QB5    4WYV   
PDB (PDBSum)1J1J    3PJA    3QB5    4WYV   
PDB (IMB)1J1J    3PJA    3QB5    4WYV   
Structural Biology KnowledgeBase1J1J    3PJA    3QB5    4WYV   
SCOP (Structural Classification of Proteins)1J1J    3PJA    3QB5    4WYV   
CATH (Classification of proteins structures)1J1J    3PJA    3QB5    4WYV   
SuperfamilyQ15631
AlphaFold pdb e-kbQ15631   
Human Protein Atlas [tissue]ENSG00000211460-TSN [tissue]
HPRD08993
Protein Interaction databases
DIP (DOE-UCLA)Q15631
IntAct (EBI)Q15631
BioGRIDTSN
STRING (EMBL)TSN
ZODIACTSN
Ontologies - Pathways
QuickGOQ15631
Ontology : AmiGODNA binding  single-stranded DNA binding  RNA binding  endonuclease activity  protein binding  nucleus  nucleoplasm  cytoplasm  endoplasmic reticulum  cytosol  DNA recombination  production of siRNA involved in RNA interference  identical protein binding  sequence-specific DNA binding  protein-containing complex binding  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBIDNA binding  single-stranded DNA binding  RNA binding  endonuclease activity  protein binding  nucleus  nucleoplasm  cytoplasm  endoplasmic reticulum  cytosol  DNA recombination  production of siRNA involved in RNA interference  identical protein binding  sequence-specific DNA binding  protein-containing complex binding  nucleic acid phosphodiester bond hydrolysis  
NDEx NetworkTSN
Atlas of Cancer Signalling NetworkTSN
Wikipedia pathwaysTSN
Orthology - Evolution
OrthoDB7247
GeneTree (enSembl)ENSG00000211460
Phylogenetic Trees/Animal Genes : TreeFamTSN
Homologs : HomoloGeneTSN
Homology/Alignments : Family Browser (UCSC)TSN
Gene fusions - Rearrangements
Fusion : QuiverTSN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSN
dbVarTSN
ClinVarTSN
MonarchTSN
1000_GenomesTSN 
Exome Variant ServerTSN
GNOMAD BrowserENSG00000211460
Varsome BrowserTSN
ACMGTSN variants
VarityQ15631
Genomic Variants (DGV)TSN [DGVbeta]
DECIPHERTSN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTSN 
Mutations
ICGC Data PortalTSN 
TCGA Data PortalTSN 
Broad Tumor PortalTSN
OASIS PortalTSN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTSN
Mutations and Diseases : HGMDTSN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTSN
DgiDB (Drug Gene Interaction Database)TSN
DoCM (Curated mutations)TSN
CIViC (Clinical Interpretations of Variants in Cancer)TSN
Cancer3DTSN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600575   
Orphanet
DisGeNETTSN
MedgenTSN
Genetic Testing Registry TSN
NextProtQ15631 [Medical]
GENETestsTSN
Target ValidationTSN
Huge Navigator TSN [HugePedia]
ClinGenTSN
Clinical trials, drugs, therapy
MyCancerGenomeTSN
Protein Interactions : CTDTSN
Pharm GKB GenePA37047
PharosQ15631
Clinical trialTSN
Miscellaneous
canSAR (ICR)TSN
HarmonizomeTSN
DataMed IndexTSN
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTSN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:37 CEST 2021

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