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TSPAN14 (tetraspanin 14)

Identity

Alias_namesTM4SF14
transmembrane 4 superfamily member 14
Alias_symbol (synonym)DC-TM4F2
MGC11352
Other alias
HGNC (Hugo) TSPAN14
LocusID (NCBI) 81619
Atlas_Id 51434
Location 10q23.1  [Link to chromosome band 10q23]
Location_base_pair Starts at 80454282 and ends at 80522635 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ABCC5 (3q27.1) / TSPAN14 (10q23.1)GRHL2 (8q22.3) / TSPAN14 (10q23.1)MTMR10 (15q13.3) / TSPAN14 (10q23.1)
SHH (7q36.3) / TSPAN14 (10q23.1)SNN (16p13.13) / TSPAN14 (10q23.1)TSPAN14 (10q23.1) / DYDC2 (10q23.1)
TSPAN14 (10q23.1) / GNB2 (7q22.1)TSPAN14 (10q23.1) / HLA-E (6p21.33)TSPAN14 (10q23.1) / SFTPD (10q22.3)
TSPAN14 (10q23.1) / TMEM254 (10q22.3)TSPAN14 (10q23.1) / TSPAN14 (10q23.1)TSPAN14 (10q23.1) / YWHAH (22q12.3)
GRHL2 8q22.3 / TSPAN14 10q23.1TSPAN14 10q23.1 / DYDC2 10q23.1TSPAN14 10q23.1 / SFTPD 10q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TSPAN14   23303
Cards
Entrez_Gene (NCBI)TSPAN14  81619  tetraspanin 14
AliasesDC-TM4F2; TM4SF14
GeneCards (Weizmann)TSPAN14
Ensembl hg19 (Hinxton)ENSG00000108219 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108219 [Gene_View]  chr10:80454282-80522635 [Contig_View]  TSPAN14 [Vega]
ICGC DataPortalENSG00000108219
TCGA cBioPortalTSPAN14
AceView (NCBI)TSPAN14
Genatlas (Paris)TSPAN14
WikiGenes81619
SOURCE (Princeton)TSPAN14
Genetics Home Reference (NIH)TSPAN14
Genomic and cartography
GoldenPath hg38 (UCSC)TSPAN14  -     chr10:80454282-80522635 +  10q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TSPAN14  -     10q23.1   [Description]    (hg19-Feb_2009)
EnsemblTSPAN14 - 10q23.1 [CytoView hg19]  TSPAN14 - 10q23.1 [CytoView hg38]
Mapping of homologs : NCBITSPAN14 [Mapview hg19]  TSPAN14 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF311903 AK025157 AK026621 AK055330 AK074558
RefSeq transcript (Entrez)NM_001128309 NM_030927
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TSPAN14
Cluster EST : UnigeneHs.718943 [ NCBI ]
CGAP (NCI)Hs.718943
Alternative Splicing GalleryENSG00000108219
Gene ExpressionTSPAN14 [ NCBI-GEO ]   TSPAN14 [ EBI - ARRAY_EXPRESS ]   TSPAN14 [ SEEK ]   TSPAN14 [ MEM ]
Gene Expression Viewer (FireBrowse)TSPAN14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81619
GTEX Portal (Tissue expression)TSPAN14
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NG11   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NG11  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NG11
Splice isoforms : SwissVarQ8NG11
PhosPhoSitePlusQ8NG11
Domaine pattern : Prosite (Expaxy)TM4_1 (PS00421)   
Domains : Interpro (EBI)Tetraspanin    Tetraspanin/Peripherin    Tetraspanin_CS    Tetraspanin_EC2   
Domain families : Pfam (Sanger)Tetraspannin (PF00335)   
Domain families : Pfam (NCBI)pfam00335   
Conserved Domain (NCBI)TSPAN14
DMDM Disease mutations81619
Blocks (Seattle)TSPAN14
SuperfamilyQ8NG11
Human Protein AtlasENSG00000108219
Peptide AtlasQ8NG11
HPRD18196
IPIIPI00303059   IPI00165394   IPI00643378   IPI00166442   IPI00641869   IPI00644703   
Protein Interaction databases
DIP (DOE-UCLA)Q8NG11
IntAct (EBI)Q8NG11
FunCoupENSG00000108219
BioGRIDTSPAN14
STRING (EMBL)TSPAN14
ZODIACTSPAN14
Ontologies - Pathways
QuickGOQ8NG11
Ontology : AmiGOplasma membrane  plasma membrane  integral component of plasma membrane  cell surface  enzyme binding  specific granule membrane  neutrophil degranulation  positive regulation of Notch signaling pathway  protein maturation  tertiary granule membrane  establishment of protein localization to plasma membrane  tetraspanin-enriched microdomain  
Ontology : EGO-EBIplasma membrane  plasma membrane  integral component of plasma membrane  cell surface  enzyme binding  specific granule membrane  neutrophil degranulation  positive regulation of Notch signaling pathway  protein maturation  tertiary granule membrane  establishment of protein localization to plasma membrane  tetraspanin-enriched microdomain  
NDEx NetworkTSPAN14
Atlas of Cancer Signalling NetworkTSPAN14
Wikipedia pathwaysTSPAN14
Orthology - Evolution
OrthoDB81619
GeneTree (enSembl)ENSG00000108219
Phylogenetic Trees/Animal Genes : TreeFamTSPAN14
HOVERGENQ8NG11
HOGENOMQ8NG11
Homologs : HomoloGeneTSPAN14
Homology/Alignments : Family Browser (UCSC)TSPAN14
Gene fusions - Rearrangements
Fusion : MitelmanGRHL2/TSPAN14 [8q22.3/10q23.1]  [t(8;10)(q22;q23)]  
Fusion : MitelmanTSPAN14/DYDC2 [10q23.1/10q23.1]  [t(10;10)(q23;q23)]  
Fusion : MitelmanTSPAN14/HLA-E [10q23.1/6p21.33]  [t(6;10)(p21;q23)]  
Fusion : MitelmanTSPAN14/SFTPD [10q23.1/10q22.3]  [t(10;10)(q22;q23)]  
Fusion: TCGAGRHL2 8q22.3 TSPAN14 10q23.1 BRCA
Fusion: TCGATSPAN14 10q23.1 DYDC2 10q23.1 BRCA LUAD
Fusion: TCGATSPAN14 10q23.1 SFTPD 10q22.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSPAN14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSPAN14
dbVarTSPAN14
ClinVarTSPAN14
1000_GenomesTSPAN14 
Exome Variant ServerTSPAN14
ExAC (Exome Aggregation Consortium)TSPAN14 (select the gene name)
Genetic variants : HAPMAP81619
Genomic Variants (DGV)TSPAN14 [DGVbeta]
DECIPHERTSPAN14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTSPAN14 
Mutations
ICGC Data PortalTSPAN14 
TCGA Data PortalTSPAN14 
Broad Tumor PortalTSPAN14
OASIS PortalTSPAN14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSPAN14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTSPAN14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TSPAN14
DgiDB (Drug Gene Interaction Database)TSPAN14
DoCM (Curated mutations)TSPAN14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TSPAN14 (select a term)
intoGenTSPAN14
Cancer3DTSPAN14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenTSPAN14
Genetic Testing Registry TSPAN14
NextProtQ8NG11 [Medical]
TSGene81619
GENETestsTSPAN14
Target ValidationTSPAN14
Huge Navigator TSPAN14 [HugePedia]
snp3D : Map Gene to Disease81619
BioCentury BCIQTSPAN14
ClinGenTSPAN14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD81619
Chemical/Pharm GKB GenePA128394731
Clinical trialTSPAN14
Miscellaneous
canSAR (ICR)TSPAN14 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTSPAN14
EVEXTSPAN14
GoPubMedTSPAN14
iHOPTSPAN14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:36:36 CEST 2017

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