TSPAN3 (tetraspanin 3)

2016-06-01  

Identity

HGNC
TSPAN3
LOCATION
15q24.3
LOCUSID
10099
ALIAS
TM4-A,TM4SF8,TSPAN-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10099
MIM: 613134
HGNC: 17752
Ensembl: ENSG00000140391

Variants:

dbSNP: 10099
ClinVar: 10099
TCGA: ENSG00000140391
COSMIC: TSPAN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140391ENST00000267970O60637
ENSG00000140391ENST00000346495O60637
ENSG00000140391ENST00000424443O60637
ENSG00000140391ENST00000558745H0YMH8
ENSG00000140391ENST00000559494H0YKJ9
ENSG00000140391ENST00000561277H0YMH8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
262120802015Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.22
269303622016Tetraspanins: Spanning from solid tumors to hematologic malignancies.12
278182722017Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.9
303675262019Tumor suppressor miR-139-5p targets Tspan3 and regulates the progression of acute myeloid leukemia through the PI3K/Akt pathway.3
318373292020LncRNA KCNQ1OT1 contributes to the progression and chemoresistance in acute myeloid leukemia by modulating Tspan3 through suppressing miR-193a-3p.1

Citation

Dessen P

TSPAN3 (tetraspanin 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-06-01

Online version: http://atlasgeneticsoncology.org/gene/55815/tspan3