TSPAN5 (tetraspanin 5)

2018-02-01  

Identity

HGNC
TSPAN5
LOCATION
4q23
LOCUSID
10098
ALIAS
NET-4,NET4,TM4SF9,TSPAN-5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10098
MIM: 613136
HGNC: 17753
Ensembl: ENSG00000168785

Variants:

dbSNP: 10098
ClinVar: 10098
TCGA: ENSG00000168785
COSMIC: TSPAN5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168785ENST00000305798P62079
ENSG00000168785ENST00000505184B7Z317
ENSG00000168785ENST00000508798D6RAR1
ENSG00000168785ENST00000511651D6RGZ7
ENSG00000168785ENST00000511800D6RBT5
ENSG00000168785ENST00000515287D6R9N6
ENSG00000168785ENST00000515440H0Y8W4

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10074escitalopramChemicalClinicalAnnotationassociatedPD26903268
PA447207Depressive DisorderDiseaseClinicalAnnotationassociatedPD26903268
PA449015citalopramChemicalClinicalAnnotationassociatedPD26903268

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
286002922017ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.9
284282482017New insights into the tetraspanin Tspan5 using novel monoclonal antibodies.6
272230872016Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer.4
299083762018The increased level of Tspan5 in villi suggests more proliferation and invasiveness of trophoblasts in tubal pregnancy.0
320962992020miR-155 increases stemness and decitabine resistance in triple-negative breast cancer cells by inhibiting TSPAN5.0

Citation

Dessen P

TSPAN5 (tetraspanin 5)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57347/tspan5