Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TSPO (translocator protein)

Identity

Alias_namesBZRP
benzodiazapine receptor (peripheral)
translocator protein (18kDa)
Alias_symbol (synonym)PBR
MBR
PKBS
mDRC
DBI
IBP
pk18
Other aliasBPBS
PBS
PTBR
HGNC (Hugo) TSPO
LocusID (NCBI) 706
Atlas_Id 858
Location 22q13.2  [Link to chromosome band 22q13]
Location_base_pair Starts at 43547520 and ends at 43559248 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AQP7P1 (9q13) / TSPO (22q13.2)BCL2 (18q21.33) / TSPO (22q13.2)PIK3CB (3q22.3) / TSPO (22q13.2)
SEPW1 (19q13.33) / TSPO (22q13.2)TTLL1 (22q13.2) / TSPO (22q13.2)VAV2 (9q34.2) / TSPO (22q13.2)
PIK3CB 3q22.3 / TSPO 22q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)TSPO   1158
Cards
Entrez_Gene (NCBI)TSPO  706  translocator protein
AliasesBPBS; BZRP; DBI; IBP; 
MBR; PBR; PBS; PKBS; PTBR; mDRC; pk18
GeneCards (Weizmann)TSPO
Ensembl hg19 (Hinxton)ENSG00000100300 [Gene_View]  chr22:43547520-43559248 [Contig_View]  TSPO [Vega]
Ensembl hg38 (Hinxton)ENSG00000100300 [Gene_View]  chr22:43547520-43559248 [Contig_View]  TSPO [Vega]
ICGC DataPortalENSG00000100300
TCGA cBioPortalTSPO
AceView (NCBI)TSPO
Genatlas (Paris)TSPO
WikiGenes706
SOURCE (Princeton)TSPO
Genetics Home Reference (NIH)TSPO
Genomic and cartography
GoldenPath hg19 (UCSC)TSPO  -     chr22:43547520-43559248 +  22q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TSPO  -     22q13.2   [Description]    (hg38-Dec_2013)
EnsemblTSPO - 22q13.2 [CytoView hg19]  TSPO - 22q13.2 [CytoView hg38]
Mapping of homologs : NCBITSPO [Mapview hg19]  TSPO [Mapview hg38]
OMIM109610   
Gene and transcription
Genbank (Entrez)AF075589 AF075590 AY998017 BC001110 BG749252
RefSeq transcript (Entrez)NM_000714 NM_001256530 NM_001256531 NM_007311
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)TSPO
Cluster EST : UnigeneHs.202 [ NCBI ]
CGAP (NCI)Hs.202
Alternative Splicing GalleryENSG00000100300
Gene ExpressionTSPO [ NCBI-GEO ]   TSPO [ EBI - ARRAY_EXPRESS ]   TSPO [ SEEK ]   TSPO [ MEM ]
Gene Expression Viewer (FireBrowse)TSPO [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)706
GTEX Portal (Tissue expression)TSPO
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30536   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30536  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30536
Splice isoforms : SwissVarP30536
PhosPhoSitePlusP30536
Domains : Interpro (EBI)TSPO    TspO_MBR   
Domain families : Pfam (Sanger)TspO_MBR (PF03073)   
Domain families : Pfam (NCBI)pfam03073   
Conserved Domain (NCBI)TSPO
DMDM Disease mutations706
Blocks (Seattle)TSPO
SuperfamilyP30536
Human Protein AtlasENSG00000100300
Peptide AtlasP30536
HPRD15913
IPIIPI00396135   IPI00026850   IPI00902656   
Protein Interaction databases
DIP (DOE-UCLA)P30536
IntAct (EBI)P30536
FunCoupENSG00000100300
BioGRIDTSPO
STRING (EMBL)TSPO
ZODIACTSPO
Ontologies - Pathways
QuickGOP30536
Ontology : AmiGOandrogen binding  protein binding  cytoplasm  mitochondrion  mitochondrial outer membrane  protein targeting to mitochondrion  steroid biosynthetic process  heme biosynthetic process  anion transport  chloride transport  lipid transport  apoptotic process  aging  steroid metabolic process  cell proliferation  glial cell migration  benzodiazepine receptor activity  response to manganese ion  response to vitamin B1  positive regulation of necrotic cell death  peripheral nervous system axon regeneration  cholesterol binding  integral component of membrane  adrenal gland development  negative regulation of protein ubiquitination  nuclear membrane  regulation of cholesterol transport  response to progesterone  negative regulation of tumor necrosis factor production  response to testosterone  response to drug  positive regulation of apoptotic process  intracellular membrane-bounded organelle  ion channel binding  negative regulation of nitric oxide biosynthetic process  behavioral response to pain  regulation of steroid biosynthetic process  positive regulation of mitochondrial depolarization  positive regulation of calcium ion transport  contact inhibition  positive regulation of glial cell proliferation  negative regulation of glial cell proliferation  extracellular exosome  cellular response to lipopolysaccharide  cellular response to zinc ion  cellular hypotonic response  maintenance of protein location in mitochondrion  postsynapse  postsynapse  chemical synaptic transmission, postsynaptic  chemical synaptic transmission, postsynaptic  negative regulation of mitophagy  negative regulation of ATP metabolic process  positive regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIandrogen binding  protein binding  cytoplasm  mitochondrion  mitochondrial outer membrane  protein targeting to mitochondrion  steroid biosynthetic process  heme biosynthetic process  anion transport  chloride transport  lipid transport  apoptotic process  aging  steroid metabolic process  cell proliferation  glial cell migration  benzodiazepine receptor activity  response to manganese ion  response to vitamin B1  positive regulation of necrotic cell death  peripheral nervous system axon regeneration  cholesterol binding  integral component of membrane  adrenal gland development  negative regulation of protein ubiquitination  nuclear membrane  regulation of cholesterol transport  response to progesterone  negative regulation of tumor necrosis factor production  response to testosterone  response to drug  positive regulation of apoptotic process  intracellular membrane-bounded organelle  ion channel binding  negative regulation of nitric oxide biosynthetic process  behavioral response to pain  regulation of steroid biosynthetic process  positive regulation of mitochondrial depolarization  positive regulation of calcium ion transport  contact inhibition  positive regulation of glial cell proliferation  negative regulation of glial cell proliferation  extracellular exosome  cellular response to lipopolysaccharide  cellular response to zinc ion  cellular hypotonic response  maintenance of protein location in mitochondrion  postsynapse  postsynapse  chemical synaptic transmission, postsynaptic  chemical synaptic transmission, postsynaptic  negative regulation of mitophagy  negative regulation of ATP metabolic process  positive regulation of reactive oxygen species metabolic process  
Pathways : KEGGNeuroactive ligand-receptor interaction    HTLV-I infection   
NDEx NetworkTSPO
Atlas of Cancer Signalling NetworkTSPO
Wikipedia pathwaysTSPO
Orthology - Evolution
OrthoDB706
GeneTree (enSembl)ENSG00000100300
Phylogenetic Trees/Animal Genes : TreeFamTSPO
HOVERGENP30536
HOGENOMP30536
Homologs : HomoloGeneTSPO
Homology/Alignments : Family Browser (UCSC)TSPO
Gene fusions - Rearrangements
Fusion : MitelmanPIK3CB/TSPO [3q22.3/22q13.2]  [t(3;22)(q22;q13)]  
Fusion : MitelmanTTLL1/TSPO [22q13.2/22q13.2]  [inv(22)(q13q13)]  
Fusion: TCGAPIK3CB 3q22.3 TSPO 22q13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSPO [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSPO
dbVarTSPO
ClinVarTSPO
1000_GenomesTSPO 
Exome Variant ServerTSPO
ExAC (Exome Aggregation Consortium)TSPO (select the gene name)
Genetic variants : HAPMAP706
Genomic Variants (DGV)TSPO [DGVbeta]
DECIPHER (Syndromes)22:43547520-43559248  ENSG00000100300
CONAN: Copy Number AnalysisTSPO 
Mutations
ICGC Data PortalTSPO 
TCGA Data PortalTSPO 
Broad Tumor PortalTSPO
OASIS PortalTSPO [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSPO  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTSPO
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TSPO
DgiDB (Drug Gene Interaction Database)TSPO
DoCM (Curated mutations)TSPO (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TSPO (select a term)
intoGenTSPO
Cancer3DTSPO(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109610   
Orphanet
MedgenTSPO
Genetic Testing Registry TSPO
NextProtP30536 [Medical]
TSGene706
GENETestsTSPO
Huge Navigator TSPO [HugePedia]
snp3D : Map Gene to Disease706
BioCentury BCIQTSPO
ClinGenTSPO
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD706
Chemical/Pharm GKB GenePA25473
Clinical trialTSPO
Miscellaneous
canSAR (ICR)TSPO (select the gene name)
Probes
Litterature
PubMed103 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTSPO
EVEXTSPO
GoPubMedTSPO
iHOPTSPO
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:32:38 CET 2017

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