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TSPO (translocator protein)

Identity

Alias (NCBI)BPBS
BZRP
DBI
IBP
MBR
PBR
PBS
PKBS
PTBR
mDRC
pk18
HGNC (Hugo) TSPO
HGNC Alias symbPBR
MBR
PKBS
mDRC
DBI
IBP
pk18
HGNC Alias nameperipheral-type benzodiazepine receptor/recognition site
HGNC Previous nameBZRP
HGNC Previous namebenzodiazapine receptor (peripheral)
 translocator protein (18kDa)
LocusID (NCBI) 706
Atlas_Id 858
Location 22q13.2  [Link to chromosome band 22q13]
Location_base_pair Starts at 43151933 and ends at 43163242 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AQP7P1 (9q13) / TSPO (22q13.2)BCL2 (18q21.33) / TSPO (22q13.2)PIK3CB (3q22.3) / TSPO (22q13.2)
SEPW1 (19q13.33) / TSPO (22q13.2)TTLL1 (22q13.2) / TSPO (22q13.2)VAV2 (9q34.2) / TSPO (22q13.2)
PIK3CB 3q22.3 / TSPO 22q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TSPO   1158
Cards
Entrez_Gene (NCBI)TSPO    translocator protein
AliasesBPBS; BZRP; DBI; IBP; 
MBR; PBR; PBS; PKBS; PTBR; mDRC; pk18
GeneCards (Weizmann)TSPO
Ensembl hg19 (Hinxton)ENSG00000100300 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100300 [Gene_View]  ENSG00000100300 [Sequence]  chr22:43151933-43163242 [Contig_View]  TSPO [Vega]
ICGC DataPortalENSG00000100300
TCGA cBioPortalTSPO
AceView (NCBI)TSPO
Genatlas (Paris)TSPO
SOURCE (Princeton)TSPO
Genetics Home Reference (NIH)TSPO
Genomic and cartography
GoldenPath hg38 (UCSC)TSPO  -     chr22:43151933-43163242 +  22q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TSPO  -     22q13.2   [Description]    (hg19-Feb_2009)
GoldenPathTSPO - 22q13.2 [CytoView hg19]  TSPO - 22q13.2 [CytoView hg38]
ImmunoBaseENSG00000100300
Genome Data Viewer NCBITSPO [Mapview hg19]  
OMIM109610   
Gene and transcription
Genbank (Entrez)AF075589 AF075590 AY998017 BC001110 BG749252
RefSeq transcript (Entrez)NM_000714 NM_001256530 NM_001256531 NM_007311
Consensus coding sequences : CCDS (NCBI)TSPO
Gene ExpressionTSPO [ NCBI-GEO ]   TSPO [ EBI - ARRAY_EXPRESS ]   TSPO [ SEEK ]   TSPO [ MEM ]
Gene Expression Viewer (FireBrowse)TSPO [ Firebrowse - Broad ]
GenevisibleExpression of TSPO in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)706
GTEX Portal (Tissue expression)TSPO
Human Protein AtlasENSG00000100300-TSPO [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30536   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30536  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30536
PhosPhoSitePlusP30536
Domains : Interpro (EBI)TSPO    TspO/MBR-related_sf    TspO_MBR   
Domain families : Pfam (Sanger)TspO_MBR (PF03073)   
Domain families : Pfam (NCBI)pfam03073   
Conserved Domain (NCBI)TSPO
SuperfamilyP30536
AlphaFold pdb e-kbP30536   
Human Protein Atlas [tissue]ENSG00000100300-TSPO [tissue]
HPRD15913
Protein Interaction databases
DIP (DOE-UCLA)P30536
IntAct (EBI)P30536
BioGRIDTSPO
STRING (EMBL)TSPO
ZODIACTSPO
Ontologies - Pathways
QuickGOP30536
Ontology : AmiGOandrogen binding  protein binding  mitochondrion  mitochondrial outer membrane  endoplasmic reticulum  cytosol  protein targeting to mitochondrion  C21-steroid hormone biosynthetic process  heme biosynthetic process  anion transport  chloride transport  lipid transport  aging  steroid metabolic process  glial cell migration  benzodiazepine receptor activity  response to manganese ion  response to vitamin B1  positive regulation of necrotic cell death  peripheral nervous system axon regeneration  cholesterol binding  cholesterol binding  integral component of membrane  adrenal gland development  negative regulation of protein ubiquitination  regulation of cholesterol transport  response to progesterone  negative regulation of tumor necrosis factor production  response to testosterone  regulation of cell population proliferation  response to drug  positive regulation of apoptotic process  intracellular membrane-bounded organelle  ion channel binding  negative regulation of nitric oxide biosynthetic process  behavioral response to pain  regulation of steroid biosynthetic process  positive regulation of mitochondrial depolarization  positive regulation of calcium ion transport  contact inhibition  positive regulation of glial cell proliferation  negative regulation of glial cell proliferation  extracellular exosome  cellular response to lipopolysaccharide  cellular response to zinc ion  cellular hypotonic response  maintenance of protein location in mitochondrion  negative regulation of autophagy of mitochondrion  negative regulation of ATP metabolic process  positive regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIandrogen binding  protein binding  mitochondrion  mitochondrial outer membrane  endoplasmic reticulum  cytosol  protein targeting to mitochondrion  C21-steroid hormone biosynthetic process  heme biosynthetic process  anion transport  chloride transport  lipid transport  aging  steroid metabolic process  glial cell migration  benzodiazepine receptor activity  response to manganese ion  response to vitamin B1  positive regulation of necrotic cell death  peripheral nervous system axon regeneration  cholesterol binding  cholesterol binding  integral component of membrane  adrenal gland development  negative regulation of protein ubiquitination  regulation of cholesterol transport  response to progesterone  negative regulation of tumor necrosis factor production  response to testosterone  regulation of cell population proliferation  response to drug  positive regulation of apoptotic process  intracellular membrane-bounded organelle  ion channel binding  negative regulation of nitric oxide biosynthetic process  behavioral response to pain  regulation of steroid biosynthetic process  positive regulation of mitochondrial depolarization  positive regulation of calcium ion transport  contact inhibition  positive regulation of glial cell proliferation  negative regulation of glial cell proliferation  extracellular exosome  cellular response to lipopolysaccharide  cellular response to zinc ion  cellular hypotonic response  maintenance of protein location in mitochondrion  negative regulation of autophagy of mitochondrion  negative regulation of ATP metabolic process  positive regulation of reactive oxygen species metabolic process  
Pathways : KEGGNeuroactive ligand-receptor interaction    HTLV-I infection   
NDEx NetworkTSPO
Atlas of Cancer Signalling NetworkTSPO
Wikipedia pathwaysTSPO
Orthology - Evolution
OrthoDB706
GeneTree (enSembl)ENSG00000100300
Phylogenetic Trees/Animal Genes : TreeFamTSPO
Homologs : HomoloGeneTSPO
Homology/Alignments : Family Browser (UCSC)TSPO
Gene fusions - Rearrangements
Fusion : MitelmanPIK3CB/TSPO [3q22.3/22q13.2]  
Fusion : MitelmanTTLL1/TSPO [22q13.2/22q13.2]  
Fusion : QuiverTSPO
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSPO [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSPO
dbVarTSPO
ClinVarTSPO
MonarchTSPO
1000_GenomesTSPO 
Exome Variant ServerTSPO
GNOMAD BrowserENSG00000100300
Varsome BrowserTSPO
ACMGTSPO variants
VarityP30536
Genomic Variants (DGV)TSPO [DGVbeta]
DECIPHERTSPO [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTSPO 
Mutations
ICGC Data PortalTSPO 
TCGA Data PortalTSPO 
Broad Tumor PortalTSPO
OASIS PortalTSPO [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSPO  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTSPO
Mutations and Diseases : HGMDTSPO
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTSPO
DgiDB (Drug Gene Interaction Database)TSPO
DoCM (Curated mutations)TSPO
CIViC (Clinical Interpretations of Variants in Cancer)TSPO
Cancer3DTSPO
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109610   
Orphanet
DisGeNETTSPO
MedgenTSPO
Genetic Testing Registry TSPO
NextProtP30536 [Medical]
GENETestsTSPO
Target ValidationTSPO
Huge Navigator TSPO [HugePedia]
ClinGenTSPO
Clinical trials, drugs, therapy
MyCancerGenomeTSPO
Protein Interactions : CTDTSPO
Pharm GKB GenePA25473
Pharm GKB PathwaysPA165111376   
PharosP30536
Clinical trialTSPO
Miscellaneous
canSAR (ICR)TSPO
HarmonizomeTSPO
DataMed IndexTSPO
Probes
Litterature
PubMed172 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTSPO
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:36:41 CEST 2021

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