TSPYL2 (TSPY like 2)

2003-06-01  

Identity

HGNC
TSPYL2
LOCATION
Xp11.22
LOCUSID
64061
ALIAS
CDA1,CINAP,CTCL,DENTT,HRIHFB2216,NP79,SE204,TSPX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64061
MIM: 300564
HGNC: 24358
Ensembl: ENSG00000184205

Variants:

dbSNP: 64061
ClinVar: 64061
TCGA: ENSG00000184205
COSMIC: TSPYL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184205ENST00000375442Q9H2G4
ENSG00000184205ENST00000578306J3KST2
ENSG00000184205ENST00000579390J3KS33

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
170694592006Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and development.37
232469612014hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14.25
173176702007Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways.24
274773892016The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.17
160791312005Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus.15
212047512011Role of the Y-located putative gonadoblastoma gene in human spermatogenesis.14
256133762015TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFβ signaling activation.14
183813592008Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis.13
201864592010Depletion of hCINAP by RNA interference causes defects in Cajal body formation, histone transcription, and cell viability.13
220387942012hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies.13

Citation

Dessen P

TSPYL2 (TSPY like 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42234/tspyl2