Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TSSK2 (testis specific serine kinase 2)

Identity

Alias_namesSTK22B
serine/threonine kinase 22B (spermiogenesis associated)
Alias_symbol (synonym)SPOGA2
FLJ38613
Other aliasDGS-G
TSK2
HGNC (Hugo) TSSK2
LocusID (NCBI) 23617
Atlas_Id 75260
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 19130808 and ends at 19132623 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TSSK2   11401
Cards
Entrez_Gene (NCBI)TSSK2  23617  testis specific serine kinase 2
AliasesDGS-G; SPOGA2; STK22B; TSK2
GeneCards (Weizmann)TSSK2
Ensembl hg19 (Hinxton)ENSG00000206203 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000206203 [Gene_View]  chr22:19130808-19132623 [Contig_View]  TSSK2 [Vega]
ICGC DataPortalENSG00000206203
TCGA cBioPortalTSSK2
AceView (NCBI)TSSK2
Genatlas (Paris)TSSK2
WikiGenes23617
SOURCE (Princeton)TSSK2
Genetics Home Reference (NIH)TSSK2
Genomic and cartography
GoldenPath hg38 (UCSC)TSSK2  -     chr22:19130808-19132623 +  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TSSK2  -     22q11.21   [Description]    (hg19-Feb_2009)
EnsemblTSSK2 - 22q11.21 [CytoView hg19]  TSSK2 - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBITSSK2 [Mapview hg19]  TSSK2 [Mapview hg38]
OMIM610710   
Gene and transcription
Genbank (Entrez)AF362953 BC037781 CR456587 HM005601 L77564
RefSeq transcript (Entrez)NM_053006
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TSSK2
Cluster EST : UnigeneHs.694070 [ NCBI ]
CGAP (NCI)Hs.694070
Alternative Splicing GalleryENSG00000206203
Gene ExpressionTSSK2 [ NCBI-GEO ]   TSSK2 [ EBI - ARRAY_EXPRESS ]   TSSK2 [ SEEK ]   TSSK2 [ MEM ]
Gene Expression Viewer (FireBrowse)TSSK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23617
GTEX Portal (Tissue expression)TSSK2
Human Protein AtlasENSG00000206203-TSSK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96PF2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96PF2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96PF2
Splice isoforms : SwissVarQ96PF2
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ96PF2
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)TSSK2
DMDM Disease mutations23617
Blocks (Seattle)TSSK2
SuperfamilyQ96PF2
Human Protein Atlas [tissue]ENSG00000206203-TSSK2 [tissue]
Peptide AtlasQ96PF2
HPRD10255
IPIIPI00289715   
Protein Interaction databases
DIP (DOE-UCLA)Q96PF2
IntAct (EBI)Q96PF2
FunCoupENSG00000206203
BioGRIDTSSK2
STRING (EMBL)TSSK2
ZODIACTSSK2
Ontologies - Pathways
QuickGOQ96PF2
Ontology : AmiGOmagnesium ion binding  magnesium ion binding  acrosomal vesicle  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  centriole  protein phosphorylation  multicellular organism development  spermatid development  intracellular signal transduction  protein autophosphorylation  
Ontology : EGO-EBImagnesium ion binding  magnesium ion binding  acrosomal vesicle  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  centriole  protein phosphorylation  multicellular organism development  spermatid development  intracellular signal transduction  protein autophosphorylation  
NDEx NetworkTSSK2
Atlas of Cancer Signalling NetworkTSSK2
Wikipedia pathwaysTSSK2
Orthology - Evolution
OrthoDB23617
GeneTree (enSembl)ENSG00000206203
Phylogenetic Trees/Animal Genes : TreeFamTSSK2
HOVERGENQ96PF2
HOGENOMQ96PF2
Homologs : HomoloGeneTSSK2
Homology/Alignments : Family Browser (UCSC)TSSK2
Gene fusions - Rearrangements
Tumor Fusion PortalTSSK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSSK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSSK2
dbVarTSSK2
ClinVarTSSK2
1000_GenomesTSSK2 
Exome Variant ServerTSSK2
ExAC (Exome Aggregation Consortium)ENSG00000206203
GNOMAD BrowserENSG00000206203
Genetic variants : HAPMAP23617
Genomic Variants (DGV)TSSK2 [DGVbeta]
DECIPHERTSSK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTSSK2 
Mutations
ICGC Data PortalTSSK2 
TCGA Data PortalTSSK2 
Broad Tumor PortalTSSK2
OASIS PortalTSSK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSSK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTSSK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TSSK2
DgiDB (Drug Gene Interaction Database)TSSK2
DoCM (Curated mutations)TSSK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TSSK2 (select a term)
intoGenTSSK2
Cancer3DTSSK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610710   
Orphanet
DisGeNETTSSK2
MedgenTSSK2
Genetic Testing Registry TSSK2
NextProtQ96PF2 [Medical]
TSGene23617
GENETestsTSSK2
Target ValidationTSSK2
Huge Navigator TSSK2 [HugePedia]
snp3D : Map Gene to Disease23617
BioCentury BCIQTSSK2
ClinGenTSSK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23617
Chemical/Pharm GKB GenePA36208
Clinical trialTSSK2
Miscellaneous
canSAR (ICR)TSSK2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTSSK2
EVEXTSSK2
GoPubMedTSSK2
iHOPTSSK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:44:29 CET 2017

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